Get the content you want anytime you want.
REGISTER NOW | SIGN IN
VIDEO

What is the LATTE-2 Trial for HIV Treatment?

JUL 26, 2017 | CONTAGION® EDITORIAL STAFF


Peter Williams, PhD, Compound Development Team Leader, HIV Projects, Janssen Global Public Health, Belgium, discusses the LATTE-2 trial for HIV treatment.

Interview Transcript (slightly modified for readability)

“This is a trial in HIV-infected patients who were brought to < 50 copies/ml of virus in their plasma with an induction period with an oral treatment with cabotegravir and 2 nucleoside analogues for 20 weeks. Once they had reached that critical threshold of < 50 copies/ml in plasma, they were randomized to be given injectable of antiretrovirals either every 8 weeks or every 4 weeks. The two drugs that were given were rilpivirine long-acting injectable or cabotegravir (from ViiV healthcare). Rilpivirine is a nonnucleoside reverse transcriptase inhibitor, which is a Janssen product that is on the market in the oral form, but the long-acting injectable form is under development with us.

Once the randomization had happened, there was a group who were allowed to continue with their oral therapy, but about 115 patients were randomized to an every 8-week regimen [of the injectable regimen], and another 115 patients to every 4 weeks, and then about 55 patients remained on the oral therapy. We studied their viral load and their tolerability of the injections over the next almost 2 years—96 weeks in total.”
To stay informed on the latest in infectious disease news and developments, please sign up for our weekly newsletter.


FEATURED
The new test can differentiate between Lyme disease and 7 other tick-borne diseases.