In 2016, a curious case
of Zika virus in a patient in Utah had health officials stumped as the patient had an unusually elevated Zika blood viral load. The patient also became the first Zika-related death
in the continental United States. Now, the Centers for Disease Control and Prevention (CDC) has released a synopsis
of the case that offers further insight into the investigation of a subsequent Zika virus infection in a family member
of the deceased.
In the synopsis, the authors report that 6 days after the index patient died, the patient’s family member, who authors refer to as “patient A,” developed “subjective fever, rash, and conjunctivitis.” Patient A had no known risk factors for the virus; he did not report traveling to an area endemic with Zika, having had any sexual contact with an individual who has traveled to an endemic area, nor did he receive any organ transplants or blood transfusions. However, the authors note that the patient was in close contact with the index patient “during his period of viremia,” and had visited the index patient’s places of residence. A urine sample collected from patient A tested positive for Zika virus.
The researchers put their efforts into finding a source of infection for patient A by identifying and surveying other family contacts, healthcare personnel, and community members who had potential contact with the index patient. They defined ‘contact’ as “a person who resided in the same household with the index patient or who had direct contact with the index patient or his blood or other body fluids.” The researchers tested blood, and sometimes urine, samples of those they contacted for Zika virus.
The researchers found that a total of 22 family members and friends had potential interaction with the index patient; of those 22 individuals, 19 met the definition of “contact.” Furthermore, of those 19 individuals, 15 lived with or visited the index patient at his residences and 13 visited him while he was hospitalized. In addition, 18 of the 19 individuals tested negative for Zika virus; only patient A tested positive. Twelve mortuary workers also interacted with the patient and met the definition of “contact;” however, all 12 workers tested negative for the virus.
Patient A “reported staying for 2 days and nights (>48 hours) in [the index patient’s] room in the intensive care unit (ICU) and reported hugging, kissing, and touching him frequently.” However, the index patient’s wife reported more “frequent and direct contact” with the index patient than patient A.
In terms of healthcare professionals, a total of 132 had potential contact with the index patient; of those professionals, 98 were available to be interviewed. Of the 98 professionals, 86 reported “contact” with the index patient. All 86 healthcare workers provided blood samples to be tested for Zika virus, and all the samples tested negative for the virus.