Antimicrobial Stewardship

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Ceftriaxone Resistance in Gonorrhea Underscores Need for Diversified Regimens
0:47
Ceftriaxone Resistance in Gonorrhea Underscores Need for Diversified Regimens
2 months ago
by
Lao-Tzu Allan-Blitz, MD, MPH(+1 more)
DOTS Trial Data Support Dalbavancin As an Option for Staph bacteremia
1:11
DOTS Trial Data Support Dalbavancin As an Option for Staph bacteremia
2 months ago
by
Megan E. Klatt, PharmD, BCIDP, DPLA (+1 more)
PeterPEN Data Could Bring Piperacillin-Tazobactam Back
1:37
PeterPEN Data Could Bring Piperacillin-Tazobactam Back
2 months ago
by
Megan E. Klatt, PharmD, BCIDP, DPLA (+1 more)
The Pressing Need for Antibiotic Alternatives
0:15
The Pressing Need for Antibiotic Alternatives
3 months ago
by
Jesus Rosado-Lugo, PhD(+1 more)
The Human and Financial Toll of C diff Recurrence
1:21
The Human and Financial Toll of C diff Recurrence
5 months ago
by
Christian John Lillis(+1 more)
Next Generation of AI is Better for Antibiotic Development
0:48
Next Generation of AI is Better for Antibiotic Development
5 months ago
by
Akhila Kosaraju, MD(+1 more)
How AI Works in Drug Discovery
0:46
How AI Works in Drug Discovery
6 months ago
by
Akhila Kosaraju, MD(+1 more)
Paul Offit short
1:05
Advocating for the PASTEUR Act
8 months ago
by
Amanda Jezek(+1 more)
Adoption of Rapid Diagnostic Tools, Susceptibility Testing for Gram-Negative Infections
0:36
Vaccines as a Secondary Strategy in the Fight Against Antimicrobial Resistance
a year ago
by
Barry Kreiswirth, PhD(+1 more)
Adoption of Rapid Diagnostic Tools, Susceptibility Testing for Gram-Negative Infections
0:52
Adoption of Rapid Diagnostic Tools, Susceptibility Testing for Gram-Negative Infections
a year ago
by
Rodney E. Rohde, PhD, MS, SM(ASCP)CM, SVCM, MBCM, FACSc; and Ryan P. McNamara, PhD(+1 more)

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A retrospective study of 225 patients across Cook County Department of Health clinics found that the novel 1-month 1HP regimen (isoniazid plus rifapentine) for latent TB infection had a completion rate comparable to standard longer regimens and was well tolerated, suggesting it may be a viable shorter alternative.

The expanding gram-negative antibiotic pipeline offers important new treatment options; however, FDA approval alone does not define a drug’s place in therapy. Clinicians must weigh the clinical problems that each agent solves, the strength of the evidence behind it, and what remains unknown before incorporating these therapies into routine practice.

This week's top infectious disease stories cover treatment strategies for daptomycin-resistant Enterococcus faecium, fluoroquinolone prescribing's link to antimicrobial resistance, the legal standing of the childhood vaccine schedule executive order, and rising vaccine exemption rates alongside declining MMR coverage that's fueling continued measles outbreaks.

The FDA has accepted Shionogi's supplemental New Drug Application seeking to expand the indication for cefiderocol (Fetroja) to pediatric patients with hospital-acquired and ventilator-associated bacterial pneumonia and complicated urinary tract infections caused by susceptible Gram-negative bacteria, with a regulatory decision expected in February 2027.