published in the June 2017 issue of Antimicrobial Resistance & Infection Control
, has revealed that when it comes to cleaning products that work against Clostridium difficile
) wipes are better than sprays.
Because of rising C. difficile
incidence in the past decade, coupled with rising costs, effective infection control measures are in demand, the researchers noted. According to the researchers, “the yearly national excess hospital cost associated with hospital-onset C. difficile
is estimated to be €4 billion for Europe, $1 billion in the United States, and $280 million in Canada.”
In general, standard disinfection procedure suggests using an unbuffered 1:10 dilution of hypochlorite, which is known to lead to reduction of C. difficile
. They write, “it is known that hypochlorite does not enhance sporulation and when used for environmental disinfection leads to a significant reduction of C. difficile
-associated diarrhea. However, hypochlorite has to be used in excessive concentrations to be effective, thereby increasing its toxic and corrosive properties. Therefore, alternative agents are needed to eradicate spores of C. difficile
For their study, the researchers tested 4 sporicidal disinfectants, such as wipes and sprays, in order to examine their efficacy against spores of distinctive C. difficile
PCR ribotypes. The team first looked at hydrogen peroxide 1.5% (Aseptix Sterimax Sporicide wipes); glucoprotamin 1.5% (Incidin plus wipes); a mixture of ethanol, propane and N-alkyl amino propyl glycine (Bacillol 30 tissues); and finally, a mixture of didecyldimonium chloride, benzalkonium chloride, polyaminopropyl, biguanide and dimenthicone as active ingredients (Formula 429 spray).
The researchers purposely contaminated tiles using a test solution with the specific C. difficile
strains (PCR ribotypes 010, 014 or 027). The investigators allowed the tiles to dry for 1 hour and then the tiles were wiped or sprayed with one of the test products, following the manufacturer’s instructions. After 5 minutes, microbiological cultures were performed by the study authors.