Jason Pogue, PharmD, BCPS, BCIDP, contextualizes preliminary data looking at this trial and other extended-spectrum beta-lactamase (ESBL) studies, which reopens the debate around carbapenem-sparing treatment options.
|Videos|November 3, 2016
A New Approach to Understanding Multidrug-resistant Infections
Author(s)Contagion Editorial Staff
Vikas Gupta, PharmD, BCPS, director of Clinical Strategy at Becton Dickinson, explains his team’s unique approach to understanding multidrug-resistant infections.
Advertisement
Vikas Gupta, PharmD, BCPS, director of Clinical Strategy at Becton Dickinson, explains his team’s unique approach to understanding multidrug-resistant infections.
Interview Transcript (slightly modified for readability)
“[When looking at multidrug-resistant organisms], it’s not just [about] how much, but where. What we wanted to do is characterize [it], in different types of settings. A lot of the focus has been around hospital-acquired infections or healthcare-associated infections, and how much is in that. And, in fact, [the] Antibiotic Threat Report from the [Centers for Disease Control and Prevention] focused a lot on that antibiotic threat in healthcare-associated infections. [It’s] a very important report, [which has] very much heightened the awareness of these resistance pathogens.
But we wanted to focus on [the topic] in a different [way that would] complement their report, [by looking] at different settings; [so, not just] patients that come to the hospital or develop these [infections] in the hospital, but also in the nonacute-care setting. Many of the clinicians and the companies that we spoke with that approached us with these types of questions felt that there was a higher prevalence [of multidrug-resistant organisms] out there and that, potentially, even in the nonacute-care setting, there may be more prevalence of these resistant organisms; this is one of the reasons why we looked at this from a different angle overall.”
Advertisement
Related to this article
Recent urinary tract infection guideline updates from multiple international
medical societies highlight evolving recommendations, including a major shift
in classification, moving from anatomy- and risk factor–based definitions
toward distinguishing localized from systemic infections.
Lori Handy, MD, provides guidance in these areas including presentation before rash onset, when patients should be considered for the inpatient setting, and what treatment looks like.
IDSA/ESCMID panel member Henry Chambers, MD, explains why the new S aureus bacteremia guidance replaces the complicated vs uncomplicated label with risk stratification, and how the statements are akin to the stages of cancer in guiding treatment decisions associated with this bacteremia.
Staphylococcus aureus Bacteremia (SAB) causes significant morbidity and globally is the leading cause of death from bloodstream infection. This month, the IDSA and ESCMID released 7 consensus statements to assist in managing individuals with SAB. This review will focus on the adult patient population and additional information on pediatric population statements can be assessed in the guideline. Here is a closer look at Consensus Statement 2: Follow-up Blood Cultures.
With a significant increase in rabies exposures this year, Rodney Rohde, PhD, talks about seeking medical attention after animal interactions as well as clinical treatment when people have been bit or scratched.
Widespread antimicrobial use disrupts vital microbial communities that regulate Earth’s biogeochemical cycles, driving antimicrobial resistance, worsening human and environmental health, and significantly contributing to climate change.
New data from the PETERPEN trial suggest that piperacillin-tazobactam may be noninferior to meropenem for early clinical outcomes in select patients with ESBL bloodstream infections, but carbapenems remain the standard of care until final mortality results are available and fully analyzed.
Advertisement
Advertisement