Fungal Infections

This first of a 2-part report on new guideline from the European Confederation for Medical Mycology (ECMM) summarizes diagnostic considerations; with part 2 describing recommended treatments.

This week, the FDA set a target date for lenacapavir’s approval, as rising cases of dengue, measles, and other emerging threats continue to spread, alongside a dairy worker transmitting avian flu to his cats.

The fixed-dose combination will be used outside the EU to treat soil-transmitted helminths and lymphatic filariasis.

Oliver A Cornely shares guidance on tackling Candida infections in an evolving landscape, including rising resistance and taxonomic changes.

Koos Korsten, MD, PhD, MSc discusses how clinical context, including prevalence and outbreak situations, influences the choice between PCR and culture-based diagnostics for Candidozyma auris.

This week, five all-oral TB regimens showed efficacy, fungal biofilm diseases remain challenging, over 2 million pastries were recalled due to contamination, and more.

Carlien Pohl-Albertyn's, PhD research highlights the role of the South African brown locust in the transmission and survival of the emerging pathogen Candida auris.

Targeted therapies represent a promising evolution in infectious disease treatment, offering precision approaches to combat resistant pathogens while addressing key limitations in traditional broad-spectrum treatments.

Kirsten Nielsen, PhD, discusses how her team’s research could lead to better understanding and treatment of cryptococcal meningitis.

European agencies warn that non-medical fungicide use may be fueling resistance in A fumigatus, a mold responsible for severe human infections.

Children with invasive candidiasis had successful outcome whether IV antifungal treatment was completed or converted to enteral to reduce risk of infusion site infections and costs.

Kansas is experiencing the largest tuberculosis outbreak in decades, a preview into vaccines and treatments up for FDA approval this winter/spring, and more.

Alejandro Krolewiecki, MD discusses the path to regulatory approval, collaboration with global health organizations, and the role of partnerships in scaling up the new treatment for neglected tropical diseases.

Investigators developed a novel prognostic model around this subset of patients treated for this fungal infection.

Alejandro Krolewiecki, MD, discussed testing a combination of albendazole and ivermectin to improve treatments for neglected tropical diseases.

This week, local health department's role in combating HAIs and AMR by strengthening infection prevention, global efforts to address fungal infections, and pandemic preparedness continue to face challenges, and more.

Following up on the goal, set in 2015, to diagnose 95% and treat 95% of serious fungal infections by year-end 2025.

Growing threat of beta-lactamase resistance genes across human and animal health, efforts to reduce HIV disparities for Black women, the "skip phenomenon" in S lugdunensis endocarditis, and more.

A new treatment of albendazole and ivermectin shows higher efficacy against Trichuris trichiura and hookworm infections, offering a new treatment approach for soil-transmitted worms.

The choice between debridement and implant exchange affects treatment outcomes for Candida-related prosthetic joint infections, highlighting the need for standardized guidelines and further research.

This week, norovirus cases linked to contaminated oysters, while the first US death from H5N1 avian influenza is confirmed, the FDA updates RSV vaccine labeling due to Guillain-Barré Syndrome risks, and more.

Rising temperatures and changing humidity are undermining natural pest control, putting North American forests at risk.

A novel approach may identify resistance earlier and get patients on a proper course of antifungals sooner.

This week, the CDC MMWR highlights a major blastomycosis outbreak and increased tularemia cases, CHOP's feedback reports improve antibiotic stewardship in pediatric pneumonia, and more.

The largest blastomycosis outbreak linked to a paper mill in Michigan and a 56% increase in tularemia cases over the past decade.

A lot of Systane Lubricant Eye Drops Ultra PF has been voluntarily recalled by the manufacturer.

Health officials are investigating an outbreak called "Dinga Dinga," which causes fever and uncontrollable shaking.

P aeruginosa is found in 11.6% of diabetic foot infection cultures from hot, humid climates.

Milad Zandi, PhD, on rising temperatures and the spread of mosquito-borne diseases like dengue, Zika, and chikungunya, increasing the risk of outbreaks in tropical and temperate regions.

Obesity significantly impacts the pharmacokinetics (PK) of antifungal drugs like echinocandins, including volume of distribution (Vd) and clearance. However, despite these PK differences, current clinical evidence generally does not support the need for universal dose adjustments in obese patients. Clinicians should consider personalized dosing based on patient characteristics, infection severity, and specific drug properties due to echinocandins' favorable safety profiles.