Get the content you want anytime you want.
REGISTER NOW | SIGN IN
VIDEO

What is Ceftazidime-avibactam?

OCT 30, 2016 | CONTAGION EDITORIAL STAFF


Madeline King, PharmD, assistant professor of Clinical Pharmacy at the University of the Sciences, Philadelphia College of Pharmacy in Philadelphia, Pennsylvania, discusses ceftazidime-avibactam and its uses.

Interview Transcript (slightly modified for readability)
 
“Ceftazidime-avibactam (Avycaz) is [an interesting] antibiotic [that] was just approved in 2015. What’s [interesting] about it is that it was approved based on phase II data, which is not typical of antibiotics – we usually wait until [there is] phase III data, which means that it is being tested in patients. It was basically approved off of a lot of in-vitro data, partly because ceftazidime itself, which is a component of the antibiotic, has been approved for decades, so we know the safety of that drug.
 
Seeing these in-vitro results of ceftazidime-avibactam against gram-negative infections was promising. The problem is we have a lot of gram-negative resistance right now, [meaning] a lot of gram-negative organisms have developed resistance to most of the antibiotics that we have. We have something called CRE infections, or carbapenem-resistant Enterobacteriaceae infections or carbapenem-resistant pseudomonal infections. Those pose a huge threat to public health, so we need new antibiotics; [therefore], the FDA and the government are trying to approve antibiotics faster, [and] this is one of those antibiotics.
 
It’s a [very interesting] agent. We’re hoping that it’s going to work really well for these [extremely] resistant organisms. The other [interesting] thing about it is the avibactam component, which is the beta-lactamase inhibitor is reversible, whereas others that have been approved in the past aren’t. Once it’s kind of done its job, it can go back and work again. It’s a pretty [great] antibiotic that we’re hoping is going to do a lot of good things.”
 
To stay informed on the latest in infectious disease news and developments, please sign up for our weekly newsletter.


Advocacy and Research Foundation Partners
FEATURED
Big advances in treatment can