When Should We De-Escalate Empiric Antimicrobials?
May 6th 2025De-escalating empiric antimicrobial therapy is a strategy to combat antimicrobial resistance. Antimicrobial stewardship programs can play a major role in preserving antibiotic effectiveness and preventing unnecessary antibiotic use.
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This common skin and soft tissue infection has a high recurrence rate and significant treatment failure. β-Lactams remain effective first-line treatments, though rising resistance to clindamycin and tetracycline, especially in GAS, is a growing concern.
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Rifaquizinone: A Novel Rifamycin-Quinolone Hybrid Antibiotic
April 28th 2025Rifaquizinone is a dual-pharmacophore antibiotic combining rifamycin and a fluoroquinolone-like compound, showing strong bactericidal activity against resistant Staphylococcus aureus strains and biofilms, with promising results for treating prosthetic joint infections (PJI) but limited oral bioavailability.
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H5N1: The Outbreak the US Got Bored With
April 21st 2025Since its detection in early 2024, H5N1 has spread to dairy cows, poultry, and wild birds. Political factors, including leadership changes at the Centers for Disease Control and Prevention and cuts to public health resources, have worsened the situation, leading to a weakened response.
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