February 3rd 2023
The biggest COVID-19 news from the past week.
The vast majority of COVID-19 infections are diagnosed at home, with rapid antigen tests. How has this affected public reports of COVID-19 prevalence?
February 2nd 2023
Though rare, Guillain-Barré syndrome can occur after vaccination. Did Pfizer-BioNTech, Moderna, or Janssen COVID-19 vaccination increase the risk of Guillain-Barré syndrome?
The agency said it was revising the Emergency Use Authorizations (EUA) for Lagevrio and Paxlovid in order to protect public health.
February 1st 2023
University of Missouri investigators found people experiencing post-acute sequelae of COVID-19 (long COVID) are susceptible to developing 7 health defects in the year following infection.
Biden Administration Makes Statement on Ending COVID-19 Public Health Emergency
The declaration set for May is a wind-down to allow health care and patients the time needed to adjust for the emergency to be over.
COVID-19 Is Now the 8th Leading Cause of Death in Children and Young Americans
COVID-19 mortalities tend to be lowest in children, but the virus is still the #8 cause of death in children and young people 0-19 years old.
“Long COVID” Caused by Hidden Viral Reservoirs
Patients suffering from post-acute sequelae of COVID-19, or “long COVID,” had virus-specific T cells that were more than 100 times higher than patients who fully recovered from COVID-19 infection.
Key Long COVID Symptoms Persist for Nearly 2 Years, But Many Return to Work
A new report tracking patients suggests that even those who return to work experience persistent symptoms.
As US COVID-19 Vaccine Policy Pivots, CDC Publishes Prevention Measures for Immunocompromised
In the latest Morbidity and Mortality Weekly Report, authors offer some strategies to avoid SARS-CoV-2 infection in this patient population as well as the US government changes course on COVID-19 vaccine policy.
The Top 5 COVID-19 Stories This Week
The week's most-clicked COVID-19 stories included vaccine updates, new variants, and a pivotal FDA advisory committee vote.
To Meet Updated FDA Recommendations, Novavax Will Update Protein-Based COVID-19 Vaccine
Novavax will update its protein-based COVID-19 vaccine, but maintains the current vaccine is effective against current and future variants.
FDA Withdraws EUA for Evusheld
The federal agency does not want clinicians utilizing this neutralizing antibody as newer, circulating COVID-19 strains and efficacy against them is limited.
FDA Advisory Committee Votes to Unify the Strain Composition of COVID-19 Primary and Booster Vaccines
The FDA’s Vaccines and Related Biological Products Advisory Committee (VRBPAC) voted to move toward a unified strain composition for COVID-19 primary and booster vaccines.
The mRNA COVID-19 Boosters Protect Against XBB and XBB15
In the CDC’s latest Morbidity and Mortality Weekly Report, investigators reported the Moderna and Pfizer-BioNTech updated vaccines helped prevent acute infection from the latest Omicron mutations.
Study Identifies Links Between Gut Dysbiosis and COVID-19
The data may help explain why COVID-19 patients experience dangerous secondary infections.
Large New Zealand Study Confirms Safety Profile of Pfizer-BioNTech Vaccine
The Pfizer-BioNTech COVID-19 vaccine was associated with rare instances of myo/pericarditis and acute kidney injury, according to a nationwide study in New Zealand that confirmed the safety profile of the vaccine.
IDSA Updates Guidelines on Neutralizing Antibodies for COVID-19
The new guidance looks at preexposure and postexposure prophylaxis as well as treatment for COVID-19.
Novavax COVID-19 Vaccine Neutralizes Omicron Mutations
A new study demonstrated continuous neutralization after 3 doses.
COVID-19 Patients Retain Elevated Risk of Death for 1.5 Years After Acute Infection
COVID-19 patients had a significantly higher risk of cardiovascular disease and death in both the short- and long-term.
Omicron Variant of COVID-19 Linked to Worse Maternal Outcome in Pregnant Women
“Vaccination coverage among pregnant women remains a priority,” the study authors noted.
Ahead of FDA VRBPAC, a Glimpse of COVID-19 Vaccine Changes
In this week’s meeting, FDA is expected to ask their advisory committee to consider changes to simplify the vaccination schedule and look at delivering it annually, much like an influenza vaccine.
Does Vaccination Before or After Infection Prevent Long COVID?
What factors contribute to post-COVID-19 conditions (“long COVID”)? Can vaccination before or after a COVID-19 infection decrease the risk of long COVID?
Americans Report Their Top Reasons for Not Receiving a Bivalent Booster
Reported reasons adults had not received a bivalent COVID-19 booster dose differed across age groups.
Comparing Pediatric COVID-19 Disease Severity Across Variants
Children were hospitalized the most during the Omicron variant, but disease outcomes were the least severe during this variant period.
Continued Declines in Childhood Vaccinations During the Pandemic
Although vaccine rates overall remain high, a new report shows a reduction 2 years in a row, leaving thousands of children not vaccinated against vaccine-preventable viruses.
IL-6 Inhibitors, Antiplatelets Improve Survival of Critically Ill COVID-19 Patients
Interleukin-6 receptor antagonists and antiplatelets are highly likely to improve long-term survival of critically ill adults with COVID-19, a recent study suggests.
PREP Act Set to Sunset in 2024 Affecting Half of US States
This act designed to allow pharmacists and technicians the ability to administer certain vaccines without a prescriber order will lapse next year. A new report looks at vaccination trends in the US and how pharmacists are playing a vital role in administering vaccines.
High Mucosal Antibodies in Airways Reduce COVID-19 Reinfection by 55%
High levels of mucosal IgA antibodies in the airways were found to protect against COVID-19 reinfection for at least 8 months.
Bivalent COVID-19 Booster Vaccination for Children Still Recommended After Safety Review
A CDC report looked at 2 vaccine safety surveillance systems for the bivalent boosters in this population and there were no reports of myocarditis or death. Many of the reports were due to vaccine errors and not adverse events.
CDC, FDA Announce Safety Signal Related to the Pfizer-BioNTech Bivalent COVID-19 Vaccine
The two agencies said one of the vaccine surveillance systems prompted an investigation into whether there was a safety concern for ischemic stroke in seniors for this booster.
Convalescent Plasma Reduced Mortality in Immunocompromised COVID-19 Patients
As COVID-19 continues to mutate, immunocompromised persons need new, effective treatments. Convalescent plasma could be the answer.
Fluvoxamine vs Placebo Did not Decrease Recovery Time in Mild to Moderate COVID-19
A randomized trial found the antidepressant to be ineffectual in helping improve time to sustained recovery.
Males Found to be More Susceptible to Respiratory Bacterial Infections
A 2-year retrospective study looking at patients admitted to the ICU showed that the number of intubated males infected with Acinetobacter baumannii (AB) was double the number of intubated females.
Addressing the Decline in the Number of Infectious Disease Physicians
Recent numbers show a lack of new people entering the field combined with existing shortfalls in many US locations.These factors demonstrate a potentially dangerous reduction in this vital medical specialty.
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