The mRNA COVID-19 Boosters Protect Against XBB and XBB15
In the CDC’s latest Morbidity and Mortality Weekly Report, investigators reported the Moderna and Pfizer-BioNTech updated vaccines helped prevent acute infection from the latest Omicron mutations.
Study Identifies Links Between Gut Dysbiosis and COVID-19
The data may help explain why COVID-19 patients experience dangerous secondary infections.
Large New Zealand Study Confirms Safety Profile of Pfizer-BioNTech Vaccine
The Pfizer-BioNTech COVID-19 vaccine was associated with rare instances of myo/pericarditis and acute kidney injury, according to a nationwide study in New Zealand that confirmed the safety profile of the vaccine.
Identifying Causes and Effects of Alcohol-Related Liver Disease
Investigators identify a mechanism that’s vital to the progression of alcohol-related hepatitis, paving the way for new treatments.
When is Fidaxomicin Cost Effective for Treating Recurrent C Difficile?
Sky-high costs with little wiggle room to negotiate mean fidaxomicin remains underprescribed for recurrent C diff, despite favorable outcomes.
FDA Advisory Committee Recommends Rezafungin for Candidemia and Invasive Candidiasis
If approved on its March PDUFA date, rezafungin could be the first new Candida treatment option in over a decade.
IDSA Updates Guidelines on Neutralizing Antibodies for COVID-19
The new guidance looks at preexposure and postexposure prophylaxis as well as treatment for COVID-19.
Staph Vaccine Ineffective in Previously Exposed Individuals
A recreation of a failed staph vaccine trial unveiled that previous exposure to S aureus made the vaccine candidate ineffective.
Novavax COVID-19 Vaccine Neutralizes Omicron Mutations
A new study demonstrated continuous neutralization after 3 doses.
COVID-19 Patients Retain Elevated Risk of Death for 1.5 Years After Acute Infection
COVID-19 patients had a significantly higher risk of cardiovascular disease and death in both the short- and long-term.
Omicron Variant of COVID-19 Linked to Worse Maternal Outcome in Pregnant Women
“Vaccination coverage among pregnant women remains a priority,” the study authors noted.
Testing, Vaccination, Contact Tracing Targets Needed to Contain Mpox in the US
Rapidly distributing vaccines to at least 1/3 of at-risk populations, in addition to increasing tasting and contact tracing, may adequately stop the spread of mpox.
Ahead of FDA VRBPAC, a Glimpse of COVID-19 Vaccine Changes
In this week’s meeting, FDA is expected to ask their advisory committee to consider changes to simplify the vaccination schedule and look at delivering it annually, much like an influenza vaccine.
Does Vaccination Before or After Infection Prevent Long COVID?
What factors contribute to post-COVID-19 conditions (“long COVID”)? Can vaccination before or after a COVID-19 infection decrease the risk of long COVID?
An Inconvenient Truth of Inadequate Global Response to Antimicrobial Resistance
An analysis of the actions taken to combat antimicrobial resistance in 114 countries finds national action plans easier to develop than to implement.
‘80% of China is Infected With COVID-19’ Health Official Reports
A Chinese epidemiologist made this claim this weekend as the country gathers for its Lunar New Year celebrations.
Americans Report Their Top Reasons for Not Receiving a Bivalent Booster
Reported reasons adults had not received a bivalent COVID-19 booster dose differed across age groups.
This Week in Infectious Disease, Recapped
Click on the slideshow images to read the full stories featured in this weekly infectious disease recap.
Taking a Daily Oral PrEP or Switching to a Long-Acting Injectable Would Prevent HIV Infections 36% and 44% Respectively
A mathematical modeling study for HPTN 083 demonstrated both forms of PrEP vs not taking anything remained efficacious in preventing infection.
Comparing Pediatric COVID-19 Disease Severity Across Variants
Children were hospitalized the most during the Omicron variant, but disease outcomes were the least severe during this variant period.
Continued Declines in Childhood Vaccinations During the Pandemic
Although vaccine rates overall remain high, a new report shows a reduction 2 years in a row, leaving thousands of children not vaccinated against vaccine-preventable viruses.
Drugs Commonly Used to Treat HIV and HBV May Reduce Immune Cells’ Energy
Tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF), antiretroviral drugs used to treat HIV and hepatitis B, may be simultaneously depleting the energy of immune cells.
Can Exercise Protect Against Severe COVID-19?
A retrospective study showed that exercise was found to have a protective association to adverse COVID-19 outcomes.
Hepatitis C Treatment Also Reduces Liver Disease and Death
What is the hepatitis C treatment uptake among people who inject drugs?
IL-6 Inhibitors, Antiplatelets Improve Survival of Critically Ill COVID-19 Patients
Interleukin-6 receptor antagonists and antiplatelets are highly likely to improve long-term survival of critically ill adults with COVID-19, a recent study suggests.
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