An Overview of Clinical Trials for COVID-19


Gain more insight on clinical trials evaluating investigational agents for COVID-19.

There are currently no approved treatments or vaccines against coronavirus disease 2019 (COVID-19). A variety of clinical trials have been initiated in order to establish evidence around investigational drugs and to identify a vaccine candidate.

This list will be updated as clinical trials continue enrolling. The following clinical trials for COVID-19 have been posted on

An Adaptive Phase 2/3, Randomized, Double-Blind, Placebo-Controlled Study Assessing Efficacy and Safety of Sarilumab for Hospitalized Patients With COVID-19

Timeline: March 18, 2020 - April 1, 2021

Interventions: Sarilumab, Placebo.

Participants: Approximately 400

Phase 2 objective: The primary objective of the study is to evaluate the clinical efficacy of sarilumab relative to the control arm in adult patients hospitalized with COVID-19 regardless of severity strata.

Phase 3 objective: The primary objective of the study is to evaluate the clinical efficacy of sarilumab relative to the control arm in adult patients hospitalized with COVID-19 (severe and critical).

Read More.

A Multi-center, Randomized, Parallel-Controlled Clinical Trial of the Application of A Hydrogen-Oxygen Generator With Nebulizer in the Improvement of Symptoms in Patients Infected With COVID-19

Timeline: February 15, 2020 - August 1, 2020

Interventions: Oxyhydrogen, Oxygen.

Participants: 100

Objective: Evaluate the efficacy and safety of Hydrogen-Oxygen Generator with Nebulizer (model AMS-H-03) as an adjuvant therapy for the patients with COVID-19 infected pneumonia in improving the clinical symptoms and reducing the incidence of severe pneumonia.

Read More.

Household Transmission Investigation Study for Coronavirus Disease 2019 in French Guiana

Timeline: March 23, 2020 — March 23, 2022

Interventions: Human biological samples.

Participants: 450

Objective: To evaluate the rate of intra-household secondary transmission of the virus.

Read More.

A Randomized, Double-blind, Placebo-controlled, Multi-site, Phase III Study to Evaluate the Safety and Efficacy of CD24Fc in COVID-19 Treatment

Timeline: April 8, 2020 — May 2022

Interventions: CD24Fc, Placebo.

Participants: 230

Objective: A randomized, placebo-controlled, double blind, multicenter, phase 3 trial to compare 2 COVID-19 treatment regimens in hospitalized adult subjects who are diagnosed with severe COVID 19.

Read More.

Use of cSVF For Residual Lung Damage COPD/Fibrotic Lung Disease After Symptomatic COVID-19 Infection For Residual Pulmonary Injury or Post-Adult Respiratory Distress Syndrome Following Viral Infection

Timeline: March 25, 2020 — December 31, 2021

Interventions: Microcannula Harvest Adipose Derived tissue stromal vascular fraction, Centricyte 1000

IV Deployment Of cSVF In Sterile Normal Saline IV Solution, Liberase Enzyme (Roche), Sterile Normal Saline for Intravenous Use.

Participants: 10

Objective: Investigate the use of autologous, cellular stromal vascular fraction deployed intravenously to examine the anti-inflammatory and structural potential to improve the residual, permanent damaged alveolar tissues of the lungs.

Read More.

A Pragmatic Adaptive Open Label, Randomized Phase II/III Multicenter Study of IFX-1 in Patients With Severe COVID-19 Pneumonia

Timeline: March 31, 2020 — December 31, 2020

Interventions: Supportive Care, Supportive Care + IFX-1.

Participants: 130

Objective: Assess the clinical benefit of the treatment using the assessed clinical parameters.

Read More.

Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734™) in Participants With Severe Coronavirus Disease

Timeline: March 6, 2020 — May 2020

Interventions: Remdesivir, Supportive Care.

Participants: 2400

Objective: The primary objective of this study is to evaluate the efficacy of 2 remdesivir (RDV) regimens with respect to clinical status assessed by a 7-point ordinal scale on Day 14.

Read More.

A Study to Evaluate the Safety and Efficacy of Tocilizumab in Patients With Severe COVID-19 Pneumonia

Timeline: April 3, 2020 — September 30, 2021

Interventions: Tocilizumab, Placebo.

Participants: 330

Objective: This study will evaluate the efficacy, safety, pharmacodynamics, and pharmacokinetics of tocilizumab compared with a matching placebo in combination with standard of care in hospitalized patients with severe COVID-19 pneumonia.

Read More.

Chloroquine Phosphate Against Infection by the Novel Coronavirus SARS-CoV-2: The HOPE Open-Label, Non Randomized Clinical Trial

Timeline: April 6, 2020 - April 30, 2021

Interventions: Chloroquine phosphate (200mg).

Participants: 60

Objective: Evaluate the activity of chloroquine phosphate in patients with SARS-CoV-2 virus infection.

Read More.

A Phase 2, Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Leronlimab for Mild to Moderate Coronavirus Disease 2019 (COVID-19)

Timeline: April 1, 2020 — April 4, 2021

Interventions: Leronlimab, Placebo.

Participants: 75

Objective: Evaluate the safety and efficacy of leronlimab in patients with mild-to-moderate symptoms of respiratory illness caused by COVID-19.

Read More.

A Phase 1b, Randomized, Double-blinded, Placebo-controlled Study of Hydroxychloroquine in Outpatient Adults With COVID-19

Timeline: March 31, 2020 — May 2020

Interventions: Hydroxychloroquine SAR321068, Placebo

Participants: 210

Objective: Assess the effect of hydroxychloroquine versus placebo on nasopharyngeal SARS-CoV-2 viral load in outpatient adults with COVID-19

Read More.

A Single-center, Open-label, Dose-escalating Phase I Clinical Trial to Evaluate Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) in Healthy Adults Aged 18-60 Years Old

Timeline: March 16, 2020 - December 20, 2022

Interventions: Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector)

Participants: 108

Objective: Evaluate the safety, reactogenicity and immunogenicity of recombinant novel coronavirus vaccine (Adenovirus type 5 vector).

Read More.

DAS181 for Severe COVID-19: Compassionate Use

Timeline: March 6, 2020 — April 30, 2020

Interventions: DAS181

Participants: 4

Objective: Investigate the safety and potential efficacy of DAS181 for the treatment of severe COVID-19.

Read More.

A Randomized Controlled Open-Label Study of CM4620 Injectable Emulsion in Patients With Severe COVID-19 Pneumonia

Timeline: April 8, 2020 — September 2020

Interventions: CM4620-Injectable Emulsion

Participants: 60

Objective: Evaluate safety, efficacy, and the pharmacokinetic profile of CM4620-IE in patients with severe COVID-19 pneumonia.

Read More.

A Phase 2/3, Randomized, Open-label, Parallel Group, 3-arm, Multicenter Study Investigating the Efficacy and Safety of Intravenous Administrations of Emapalumab, an Anti-interferon Gamma (Anti-IFNγ) Monoclonal Antibody, and Anakinra, an Interleukin-1(IL-1) Receptor Antagonist, Versus Standard of Care, in Reducing Hyper-inflammation and Respiratory Distress in Patients With SARS-CoV-2 Infection.

Timeline: April 2, 2020 — September 2020

Interventions: Emapalumab, Anakinra

Participants: 54

Objective: Assess the efficacy and safety of Emapalumab or Anakinra, versus standard of care.

Read More.

Convalescent Plasma to Reduce Complications Associated With COVID-19 Infection: A Randomized Trial Comparing the Efficacy and Safety of High-Titer Anti-SARS-CoV-2 Plasma vs. Standard Plasma in Hospitalized Patients With COVID- 19 Infection

Timeline: April 8, 2020 — August 31, 2021

Interventions: Convalescent Plasma, Standard Donor Plasma

Participants: 500

Objective: Find out if transfusion of blood plasma containing antibodies against COVID-19 (anti-SARS-CoV-2), which were donated from a patient who recovered from COVID-19 infection, is safe and can treat COVID-19 in hospitalized patients.

Read More.

An Open Clinical Trial to Evaluate Danoprevir Sodium Tablets Combined With Ritonavir in the Treatment of SARS-CoV-2 Infection

Timeline: March 18, 2020 — May 31, 2020

Interventions: Danoprevir+Ritonavir

Participants: 40

Objective: Evaluation of the efficacy and safety of Danoprevir sodium tablet combined with ritonavir for SARS-CoV-2 infected patients.

Read More.

Phase 1 Open-label Study to Evaluate the Safety, Tolerability and Immunogenicity of INO-4800, a Prophylactic Vaccine Against SARS-CoV-2, Administered Intradermally Followed by Electroporation in Healthy Volunteers

Timeline: April 3, 2020 — November 2020

Interventions: NO-4800, CELLECTRA 2000

Participants: 40

Objective: Evaluate the safety, tolerability and immunological profile of INO-4800 administered by intradermal injection followed by electroporation using CELLECTRA 2000 device in healthy adult volunteers.

Read More.

An Open Label Safety Study of Inhaled Gaseous Nitric Oxide (gNO) for Adults & Adolescents With Non-Tuberculous Mycobacteria, Burkholderia Spp, Aspergillus Spp and Corona-like Viral (Sub-Study) Infections

Timeline: October 24, 2017-March 31, 2021

Interventions: Nitric Oxide 0.5 % / Nitrogen 99.5 % Gas for Inhalation

Participants: 20

Objective: Provide more data to see if nitric oxide therapy can reduce the bacterial load in the lungs, help the patients breath better; and in the case of COVID-19 act as a anti-viral agent resulting in the reduction of incidence of oxygen therapy, mechanical assistance of BIPAP, CPAP, intubation and mechanical ventilation during the study period.

Read More.

A Randomized, Double-blind, Placebo-controlled Phase II Clinical Trial to Evaluate the Safety and Immunogenicity of the Recombinant Novel Coronavirus Vaccine (Adenovirus Vector) in Healthy Adults Aged Above 18 Years

Timeline: April 12, 2020 - January 31, 2021

Interventions: Recombinant novel coronavirus vaccine (Adenovirus type 5 vector), Placebo

Participants: 500

Objective: Evaluate the immunogenicity and safety of Ad5-nCoV which encodes for a full-length spike protein of SARS-CoV-2.

Read More.

COVID-19-associated ARDS Treated With DEXamethasone: an Open-label, Randomized, Controlled Trial: CoDEX (Alliance Covid-19 Brasil III)

Timeline: April 13, 2020 - August 30, 2020

Interventions: Dexamethasone

Participants: 290

Objective: Evaluate the effectiveness of dexamethasone compared to control (no corticosteroids) in patients with moderate and severe ARDS due to SARS-CoV2 virus.

Read More.

An Open-label, Randomized Controlled Trial of Hydroxychloroquine and Azytromicyn for COVID-19 Infection on Hospitalized, Noncritical Patients

Timeline: April 2020 - August 2020

Interventions: Hydroxychloroquine Oral Product, Hydroxychloroquine + azithromycin

Participants: 630

Objective: Compare standard of care, hydroxychloroquine plus azythromycin and hydroxychloroquine monotherapy for treatment of hospitalized patients with COVID-19.

Read More.

Related Videos
© 2024 MJH Life Sciences

All rights reserved.