Children Capable of Carrying High Levels of Live COVID-19 Virus
Infants, children, and adolescents can carry and spread COVID-19 at the same rate as adults.
Once believed to be incapable of contracting the virus, recent data estimates pediatric cases comprise 16% (5.7 million) of all COVID-19 infections.
Infected children are more likely to have asymptomatic or mild COVID-19, but they still transmit the virus to adults and other children at a similar rate. Hospitalization and mortality rates are still far lower for children than adults, but the Delta variant has driven this up dramatically.
A new study conducted by the Departments of Pediatrics, Microbiology, and Neurobiology at the University of Alabama at Birmingham aimed to detail the virological characteristics of children infected with COVID-19. The study included a cohort of 110 children who presented to the Massachusetts General Hospital or urgent care clinics with symptoms of or exposure to COVID-19 from April 2020-2021.
Upper respiratory tract (nasopharyngeal, oropharyngeal, and anterior nasal) swabs were collected from all children. Most of the children presented due to potential COVID-19 exposure, and the other 30 had asymptomatic infection. One in three were hospitalized and 18 had moderate to severe infection.
Notably, viral load (determined using a quantitative PCR test) of the children had no correlation with age, duration of symptoms, or severity of infection, while past studies of adults consistently found higher viral load in COVID-19 patients with severe disease. All children in the study, asymptomatic and symptomatic, shed higher levels of infectious virus and viral RNA during the first five days of infection. Viral RNA sequencing showed that the children in the study were infected with the same viruses as the rest of the community, suggesting that the children were not hosting novel viral variants at the time.
The study attributed the rise in COVID-19 incidence among children to the reopening of schools and relaxing of COVID-19 preventative measures. The investigators expressed concerns that continued transmission of COVID-19 among children and from children to adults will increase the chance of new viral variants emerging.