Risk Factors Associated with Readmission after COVID-19 Hospitalization


After an initial hospitalization for COVID-19, some patients may have specific risk factors that increase their likelihood of readmittance.

covid-19 patient

Even after being cleared, hospitalized COVID-19 patients are not uncommonly readmitted.

In collaboration with Ascension St. John Hospital in Detroit, MI, investigators looked to identify risk factors for readmission after COVID-19 hospitalization.

They conducted a historical cohort study, including COVID-19 cases diagnosed via PCR testing from March 8-June 14, 2020. The study included 391 patients who survived initial hospitalization for COVID-19, and subsequently identified patients readmitted within 30 days of their release.

Investigators used the electronic medical record to collect demographic and clinical data, which were analyzed using Student’s t-test, the chi-squared test, and multivariable logistic regression.

The readmission rate was 13.3% (52 of 391 readmitted). The average time to readmission was 9.2 (± 7.9) days. The average age of the readmitted patients was 66.3 (± 18.6) years; the average age of patients not readmitted was 61 (± 16) years. 44.2% were male, and 78.8% were Black/African American. The most common symptom among the readmitted was shortness of breath (50%). The most frequent diagnosis for readmission was infectious process (57.7%).

Investigators also found that a need for ICU admission or mechanical ventilation during a patient’s initial hospitalization did not increase the risk of readmission. Readmitted patients had a higher prevalence of comorbidities, specifically heart failure and renal disease. Elevated alanine aminotransferase (AST) and/or low albumin level were also correlated with readmission. Of those readmitted, the mortality rate was 11.5%.

The multivariable analysis showed independent predictors of 30-day readmission, including higher Charlson score (p=0.004), higher creatinine on admission in the index hospitalization (p=0.009), and presence of rhabdomyolysis during the index hospitalization (p=0.039).

Of the patients readmitted, infectious etiologies were common. The independent predictors of hospital readmission within 30 days speak for themselves, but the investigators recommended further study into contributing risk factors.

Related Videos
© 2024 MJH Life Sciences

All rights reserved.