Top 5 Infectious Disease News Stories Week of February 15-22
This week, the FDA set a target date for lenacapavir’s approval, as rising cases of dengue, measles, and other emerging threats continue to spread, alongside a dairy worker transmitting avian flu to his cats.
New Bat Coronavirus Has Capacity to Spread to Humans
Chinese researchers say this newly discovered virus can be transmitted to humans much the way COVID-19 did.
CHMP Approves Ivermectin/Albendazole Combination for Parasitic Worm Infections
The fixed-dose combination will be used outside the EU to treat soil-transmitted helminths and lymphatic filariasis.
Emerging Threats and Key Knowledge From 2024 Trending Into 2025
Jeff Freiberg, MD, PhD, on the rising emerging infection concerns of dengue, mpox, measles, and H5N1 influenza in clinical practice.
Indoor Domestic Cats Within Dairy Worker Households Contract Avian Influenza
Two cats became severely ill, and both owners declined to be tested.
High Uptake for RSV Vaccine and Nirsevimab Among Pregnant Women, Infants
A new study published in JAMA Network Open points out that immunization also occurred in individuals who did not receive routine prenatal or infant vaccines.
Ginkgo Bioworks Targets Infectious Disease with Rapid Respiratory Virus Detection System
Andrew Engeli explains Ginkgo's role in the €24 million EU-Funded RANGER project for emerging infectious disease surveillance and response.
Paxlovid Does Not Significantly Reduce COVID-19 Hospitalization, Mortality in Vaccinated Older Adults
In a novel, natural experiment associated with age and the antiviral, investigators were able to see the effects of the therapy in a group of adults considered to be more at risk for hospitalization and death.
Persistent Fever as a Key Mortality Predictor in MRSA Bacteremia
Sean Ong discusses how persistent fever beyond 72 hours emerges as a stronger predictor of mortality in MRSA bacteremia compared to CRP and WBC counts.
Addressing the Threat of Candida Infections Through Resistance and Management
Oliver A Cornely shares guidance on tackling Candida infections in an evolving landscape, including rising resistance and taxonomic changes.
Recce Pharmaceuticals Reports Positive Data from Phase 2 Study for its Gel for ABSSSI
The company’s investigational gel, RECCE 327, met primary and secondary endpoints, and it plans to progress to a phase 3 trial.
Early Detection of Measles in Wastewater Highlights Silent Transmission Risks
Elke Wollants explains how wastewater surveillance in Belgium provided an early warning for measles outbreaks, offering insights into broader virus circulation.
Investigational Staphylococcus aureus Vaccine Begins Phase 1 Study
The trial is being conducted by LimmaTech Biologics, and the first participants have been vaccinated.
Measles Outbreak in Texas Expands to 58 Cases, Hospitalizations Increase
Confirmed measles cases in Texas have risen from 24 to 58 in just six days, with 13 hospitalizations reported.
FDA Sets PDUFA Date for Lenacapavir For HIV Prevention
The Prescription Drug User Fee Act (PDUFA) date is set for June 19. And if it is approved, it would be the first and only twice-yearly HIV pre-exposure prophylaxis (PrEP).
Strengthening Observational Studies: Community Engagement and Data Practices
Emily Ricotta, PhD, MSc outlines the importance of involving affected populations and refining data collection methods to improve early decision-making during epidemics
Wyoming Reports First Case of Avian Influenza
A state official says the woman is hospitalized in another state, and had preexisting health conditions that can make people more vulnerable to illness.
Optimizing Detection of Candidozyma auris: Insights into PCR and Culture-Based Methods
Koos Korsten, MD, PhD, MSc discusses how clinical context, including prevalence and outbreak situations, influences the choice between PCR and culture-based diagnostics for Candidozyma auris.
FDA Places Hold on Moderna’s Norovirus Vaccine Over a Single Case of Guillain-Barré Syndrome
The company's trivalent vaccine (mRNA-1403) was being studied in a phase 3 trial.
The Role of Observational Studies in Epidemic Responses
Emily Ricotta, PhD, MSc, discusses how observational studies shape early decisions and address challenges in infectious disease outbreaks
Louisiana Surgeon General Advocates Personal Choice for Vaccinations, With Limited Discussions Around Immunizations
In a statement, the official, Ralph Abraham, MD, along with the state’s deputy surgeon general, wrote that because of “COVID missteps” they will no longer encourage vaccination to people.
Top 5 Infectious Disease News Stories Week of February 8-15
This week, five all-oral TB regimens showed efficacy, fungal biofilm diseases remain challenging, over 2 million pastries were recalled due to contamination, and more.
FDA Approves GSK’s Penmenvy Vaccine Targeting Meningococcal Serogroups A, B, C, W, and Y
In the Phase 3 trial, GSK's vaccine met all 11 primary endpoints, providing expanded options for preventing invasive meningococcal disease in individuals aged 10-25 years.
FDA Approves Bavarian Nordic’s Chikungunya Vaccine or Those 12 and Older
The approval is based on positive phase 3 clinical trial results, offering an effective option for travelers and others at risk of chikungunya, the mosquito-borne illness.
Science Is Science: Navigating Clinical Trust Amid Political Shifts
Su H Wang, MD, FACP, MPH discusses combating vaccine misinformation, preventing outbreaks, and highlighting global health interconnectedness
US Health Policy Changes Threaten Global Public Health Cooperation
Su H Wang, MD, FACP, MPH, cautions that the US withdrawal from the WHO and cuts to critical health programs may reverse progress in global health, with vulnerable populations being particularly at risk.
Investigational E coli Vaccine Does Not ‘Demonstrate Sufficient Efficacy’ in Phase 3 Study
As a result of an independent committee’s determination, the study has been discontinued.
Global Spread of the LP.8.1 SARS-CoV-2 Variant
Kei Sato, PhD, provides insights into the factors driving the spread and immune resistance of the LP.8.1 SARS-CoV-2 variant across different countries.
Could Inoculum Effect in Staph Endocarditis Affect Choice of Antibiotic?
An inoculum effect in methicillin-susceptible S aureus infective endocarditis is suspected factor in higher all-cause 30-day mortality with cephazolin treatment than with oxacillin.
Insects May Aid Spread of Fluconazole-Resistant Candida auris
Carlien Pohl-Albertyn's, PhD research highlights the role of the South African brown locust in the transmission and survival of the emerging pathogen Candida auris.