A team of investigators studied Clostridioides difficile infection (CDI) isolates to gauge resistance in the 2 antibiotics.
Although CDI remains the most common healthcare-associated infection, antimicrobial resistance surveillance for C difficile remains limited.
As such, a team at the University of Houston College of Pharmacy examined hospitalized CDI patient samples from 2 Greater Houston Area health systems to further understand potential vancomycin (VAN) and metronidazole (MTZ) resistance.
“Of 355 isolates analyzed, 18% and 26% were resistant to MTZ and VAN, respectively,” the investigators wrote. “MTZ MICs ranged from 0.25 – 8 mg/L, with a MIC50 of 0.25 mg/L and a MIC90 of 2 mg/L. VAN MICs ranged from 0.5 – 16 mg/L, with a MIC50 of 2 mg/L and a MIC90 of 4 mg/L. RT F027 demonstrated increased resistance to both VAN and MTZ. A subgroup analysis based on location exhibited numerically higher susceptibility rates at community institutions versus hospitals in the TMC.”
The study, “A Multi-institutional C difficile Antibiogram for Vancomycin and Metronidazole Susceptibility,” was presented at the
Contagion spoke to study coauthor Taryn Eubank, PharmD, BCIDP, Infectious Diseases Research fellow, University of Houston College of Pharmacy at the MAD-ID meeting who provided insights on the study and some of the takeaways looking at susceptibility testing.
