|Podcasts|June 6, 2023

High-Risk Patients and Complicated UTIs: Who's at Risk and Why?

Author(s)Nina Cosdon

Recognizing high-risk patients is crucial for effective management of UTIs, explains Kim Leuthner, PharmD, FIDSA.

Certain patient populations are at a higher risk of developing complicated UTIs.

In this first of 4 mini podcasts, Kim Leuthner, PharmD, FIDSA, explains the nuanced differences between complicated and uncomplicated urinary tract infections (UTIs).

Complicated UTIs involve factors such as devices, surgical involvement, and anatomical abnormalities that increase the risk of complications and bacterial infection. Treating these infections becomes more difficult due to the presence of a larger pathogen breeding ground. Understanding this difference is crucial for tailoring therapies to the specific needs of patients, says Leuthner.

Distinguishing between asymptomatic bacteria and complicated UTIs is important because not all patients with bacteria in their urine require treatment. While the urine and bladder can harbor bacteria without causing symptoms, patients with complicated devices provide an opportunity for pathogens to cause actual infections.

The presence or absence of symptoms is the key differentiating factor. Patients with complicated UTIs experience systemic symptoms like fever, aches, and back pain, while asymptomatic patients only exhibit the presence of bacteria in their urine. Proper differentiation guides appropriate treatment decisions.

At-risk patients include men, who face unique complications related to the prostate. Transplant patients and individuals with kidney stones, bladder stones, hydronephrosis, or stents are also prone to complications due to surgical interventions and abnormal urinary tract function. Identifying these high-risk patients is vital to ensure timely and appropriate management of UTIs.

Leuthner is an infectious disease clinical specialist at the University Medical Center of Southern Nevada. Come back tomorrow for the next installment in this podcast series!



Related to this article

FAQ: Ebola Prevention, Treatment and the Chances of a US Outbreak
As the Bundibugyo virus outbreak in the Democratic Republic of the Congo surpasses 9300 confirmed cases and 4400 deaths, this FAQ explains how the virus spreads, how it presents, why it is hard to diagnose and treat, which vaccines and therapies are being tested, and why CDC considers the risk to the United States low.
Measles Update: October 16, 2026
The latest CDC numbers show an 8.1% increase in measles cases from week-to-week, bringing the 2026 US total to 4410 confirmed cases. A CDC disease detective is going to Pennsylvania to aid in the state's massive outbreak, and the agency reports on a rare measles complication that is uniformly fatal.
FAQ: What You Need to Know About West Nile Virus in 2026
After 2 adults died of West Nile virus in central North Carolina this month, this FAQ explains how the mosquito-borne virus spreads, who faces the greatest risk of severe neuroinvasive disease, and how clinicians can diagnose, manage, and help prevent infection when no vaccine or antiviral treatment exists.