Case Western Reserve University School of Medicine researchers identify accentuated risks for age-associated comorbidities in those living with HIV.
Due to advancements made in treatment efforts, those infected with HIV are living longer lives. In fact, 45% of HIV-positive individuals living in the United States are those aged 50 or older. However, their lifespans are still about 5 years shorter than those of the general population.
As HIV becomes a disease of older Americans, it is time for all health care professionals to recognize the age-associated comorbidities unique to this population. In a recent article published in the journal Infectious Disease Clinics of North America, Case Western Reserve University School of Medicine cover key points regarding accentuated risks for age-associated comorbidities in those living with HIV.
The authors explained that HIV infection and some of its treatments use mechanisms that normal cells use to age; thus, cellular senescence may be accelerated. Genetic instability and altered intracellular communication also increase the likelihood of comorbidities.
Pharmacists in all types of practice should be especially familiar with this population because they are likely to see them as patients, if not specifically for HIV, then for age-associated comorbidities. Consider this:
The authors recommended early and aggressive treatment with antiretroviral therapy, followed by careful screening for age-associated comorbidities. Clinicians should order cancer screenings following the guidelines, with heightened vigilance in patients who smoke.
“Effective care of older HIV-infected adults that focuses on quality of life will need to span from effective treatment of HIV to preventing and managing polymorbidity to appraisal of social determinants of health and more seamlessly integrate community and social services into health care delivery,” the study authors conclude.