Krutika Kuppalli, MD, FIDSA; and Syra Madad, DHSc, MSc

Infectious diseases have repeatedly reshaped the course of civilization, resulting in significant human suffering and death along with substantial economic costs. Over the past 40 years, there has been a 4-fold increase in the number of emerging pathogens, such as extensively drug- resistant tuberculosis (XDR-TB), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), pandemic H1N1, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Nipah virus, Zika virus, Multi Drug Resistant Organisms (MDROs), and Ebola virus.

 Public health threats and infectious diseases respect neither boundaries nor barriers, and 70% of the world is underprepared to prevent, detect, and respond to them quickly and effectively.

In this era of increasingly mobile and connected populations, it is possible for an infection to spread around the world in 24 to 48 hours, due to urbanization, human behavior, and rapid transportation networks.

SARS CoV-2, the virus responsible for the COVID-19 pandemic, is the latest novel pathogen to emerge, leading to over 95 million cases and 2 million fatalities globally as of January 18, 2021.

 Although the pandemic has had a broad human, economic, and social impact, it is one of many infectious diseases that has had important public health implications over the past year. In this article, we review and discuss some of the most notable infectious disease outbreaks and trends of the past year and where appropriate, indicate how they were impacted by COVID-19.

As the world rang in 2020, most of the global health community was focused on the 10th Ebola virus disease (EVD) outbreak that had been ravaging eastern Democratic Republic of the Congo (DRC) since 

 Although the DRC had successfully contained more EVD outbreaks than any other country in the world, trying to end the one in the eastern North Kivu and Ituri provinces was difficult given the challenges of it occurring in a war zone. This outbreak was unlike any in the past; insecurity from years of violence had caused deep-seated community mistrust, intensifying the largest and most complex outbreak in the country’s history.

As COVID-19 gained traction across the globe, attention and resources shifted away from Ebola toward understanding and containing the newly emerging pathogen. Despite this pivot, the global community’s investment in developing fundamental principles of outbreak response and their commitment to deploying a vaccine in eastern DRC were critical to declaring an end to the Ebola outbreak on June 25, 2020. Similarly, it was the swift implementation of these principles that allowed DRC to quickly detect, isolate, contain, trace, and declare an end to their 

, in less than 6 months which arose in Equateur Province on June 1, 2020, and was declared over on November 18, 2020.

The core principles of an Ebola response are anchored in any good infectious disease outbreak response. They include disease surveillance, strengthening laboratory capacity, infection prevention control, isolation and quarantine of suspect cases, contact tracing, and investment in building health care systems. Investment in these components began in 2018 at the beginning of the Ebola outbreak; thus, when COVID-19 emerged, the country was prepared to tackle this new threat. Since the emergence of the COVID-19 pandemic, the government has reinforced public health measures such as the mandatory wearing of face masks in public and limiting the number of individuals who can gather in crowds.

 to implement community awareness campaigns and engagement around COVID-19 via radio, SMS communications, and mobile caravans.

 The combined efforts have been positive, and as of January 18, 2021 the DRC has reported approximately 

While the world fights a new foe, we are still in the midst of combating long-standing adversaries such as vaccine-preventable diseases. Despite historic achievements in vaccine development and availability, more than 

 people worldwide die each year from vaccine-preventable diseases.

 The COVID-19 pandemic has disrupted the way we fight diseases such as measles, diphtheria, and polio by hindering routine immunization services around the world. This puts at least 

 million children under age 1 in at least 

 countries, both poor and rich, at risk of these dangerous diseases.

 Diphtheria, for example, is appearing in Nepal, Pakistan, and Bangladesh; in polio-endemic Afghanistan and Pakistan, eradication efforts are threatened by the pandemic. Furthermore, nearly 

 countries may have put off their measles campaigns for 2020 or 2021, even though the World Health Organization has reported at least 

 cases of measles in 10 countries between May and October 2020.

Even in the United States, vaccine-preventable diseases still pose a significant threat. Whooping cough (pertussis), for example, remains common, resulting in 

 Cases were still occurring throughout the country in 2020. A Florida Department of Health 

 in June 2020 shows a general decrease in certain vaccine-preventable activity, but also notes that the pandemic has affected health seeking behavior, which may be affecting diagnoses and reporting.

Delays and disruption to vaccine administration programs from measles to polio can set back years of progress made in global health, endanger children’s health, lead to loss of herd immunity, and have a costly impact on health care. Additionally, it can further strain hospitals, affect productivity and the economy due to illness, increase disability and death, and create the potential for larger outbreaks around the world.

The prevalence of multidrug-resistant organisms (MDROs) is increasing globally and locally, including here in the United States. An emerging multidrug-resistant fungus, 

 has become a scourge in many countries and has caused havoc in the US over the past few years.

, 22 states have reported 1433 confirmed and 30 probable cases.

Although COVID-19 has dominated the headlines, MDROs continue to spread, often unchecked, with ongoing 

 in California from August 2020, for example, noted that staying vigilant and preventing the spread of MDROs and 

 is still of the utmost importance amidst the ongoing pandemic, as increased numbers of 

 continue to be reported. In fact, the advisory noted that 

 cases in California had more than doubled in health care facilities from May (n = 15) to June (n = 40) 2020. In July 2020 cases (N = 73) also exceeded the combined total number of cases in April, May, and June (n = 59) 2020.

 This noted increase is attributed to conservation strategies that facilities were using for COVID-19, such as extended use and reuse of personal protective equipment (PPE) and other containment practices such as grouping patients based on COVID-19 status.

 is not the only MDRO emerging during the pandemic. A hospital in New Jersey also 

 a cluster of 34 cases of carbapenem-resistant 

 (CRAB), which peaked during the spring surge of COVID-19 hospitalizations due to deviations in infection control strategies.

C. auris bloodstream infections in critically ill patients with COVID-19 were noted in 2.5% of intensive care unit patients between April and July 2020.

otential attribution of infection was via indwelling invasive devices, contamination of the hospital environment, and incorrect and extended use of PPE leading to self-contamination and transmission of the opportunistic fungal pathogen. Likewise, the COVID-19 pandemic is affecting antimicrobial stewardship activities and driving antimicrobial resistance around the 

Overall, COVID-19 is leading to increased hospitalization rates of high-acuity patients, longer hospital stays in crowded facilities, antimicrobial overuse, extended use and re-use of PPE, and shortages of staff. Such factors play a role in contributing to the emergence and rise of health care–acquired infections with MDROs.

Currently, the global health workforce and its resources are stretched thin and are mostly dedicated to combating the COVID-19 pandemic. If Ebola, Zika virus, 

, SARS-CoV-2, and other emerging infections have taught us anything, it is that we must work with partners in other countries, particularly those that have limited resources to combat emerging infectious diseases. This is where novel pathogens are likely to emerge but unlikely to be recognized and reported quickly as a result of fragile healthcare infrastructure. As a result, we also must invest in strengthening global capacities across the globe such as public health and health care systems, to prevent, detect, and respond to infectious diseases threats in resource-limited settings. These measures will help move us toward strengthening the global health security agenda and meeting global pandemic preparedness goals. Finally, we need sustained resources to support resource-limited countries in strengthening surveillance and reporting systems, laboratory capacities, infection control efforts, and health care workforce training. This will ensure we have a robust capacity and capability to develop new tools and approaches to respond to infectious diseases with pandemic potential.

The world is constantly changing. We have altered how we live and the planet on which we live, including the way we interact with nature, manmade environments, and animals. We have changed the way we travel, and our climate. This has created the perfect storm for infectious diseases outbreaks and unprecedented opportunities to prevent and respond to them. Critically, we must work together as a global community to address COVID-19 and prepare for future emerging infectious disease threats.

Krutika Kuppalli, MD, FIDSA, is an assistant professor in the Division of Infectious Diseases at Medical University of South Carolina in Charleston and an Emerging Leader in Biosecurity Fellow at Johns Hopkins Center for Health Security in Baltimore, Maryland.

Syra Madad, DHSc, MSc, is an infectious disease epidemiologist serving as the senior director of the System-wide Special Pathogens Program at NYC Health + Hospitals, and health and safety lead of the NYC Test & Trace Corps Enhanced Investigation Unit, in New York, New York.

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In this era of increasingly mobile and connected populations, it is possible for an infection to spread around the world in 24 to 48 hours.

Krutika Kuppalli, MD, FIDSA; and Syra Madad, DHSc, MSc

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