May 20th 2021
Rates of in-hospital mortality and days with bacteremia were similar between the two study cohorts.
June 11th 2020
The antibacterial is efficacious in a majority of patients in a small study.
February 19th 2020
The MRSA infection investigation was halted by the data and safety monitoring board due to concerns over acute kidney injury.
February 14th 2020
Therapy options have increased in recent decades, yet there is a lack of guidance.
January 7th 2020
Earlier initiation of DAP-CPT combination therapy may be beneficial, despite a tendency to use the therapy after initial treatment failure.
Why Have Efforts to Vaccinate Against S aureus Failed?
A new study published in the Journal of Clinical Investigation may offer some insight on why past efforts to develop a vaccine for S aureus have failed.
The Burden of MRSA and S aureus in Nursing Homes
How many nursing homes have these microbes?
Preliminary Negative Cultures for the De-Escalation of MRSA Therapy
This article evaluates the point in microbiological workup at which results of respiratory secretion and blood cultures could be interpreted as excluding MRSA and, thus, no longer warrant the empirical vancomycin therapy.
FDA Grants Marketing Authorization for Novel MRSA Diagnostic Test
The test is a new diagnostic tool that uses bacterial viability and a novel technology to detect bacterial colonization of Methicillin-resistant Staphylococcus aureus.
Household Environments Are a Key Reservoir for MRSA Transmission
Common interventions such as frequent hand washing can help stop the spread of methicillin-resistant Staphylococcus aureus, according to a new study that identified household environments as a reservoir for the bacteria.
Contact Precautions in Long-Term VA Facilities Don't Cut MRSA Infections, Study Shows
Although use of gowns and gloves in targeted settings may still be helpful in preventing health care-associated infections, contact precaution policies in VA long-term care facilities had no impact on MRSA acquisition.
UV Disinfection Tackles MRSA—What About C Diff?
Can UV disinfecting lights tackle health care-associated infections?
A New Approach to Discontinuing MRSA/VRE Isolation Precautions
Removing isolation for endemic patients could make a big difference.
Combination Therapy for MRSA Bloodstream Infections: Still a Question Mark
Daptomycin plus β-lactam therapy was associated with reduced composite definition for clinical failure but, worryingly, was also linked to increased risk of acute kidney injury.
Cigarette Smoke Boosts Virulence Potential of S aureus, Making It More Resistant
Investigators exposed 6 genetically distinct, clinically relevant methicillin-resistant S aureus isolates to cigarette smoke to analyze how this contact altered specific virulence phenotypes.
Proactive WGS Offers a Cost-Effective Tool for MRSA Infection Control
Although conducting whole genomic sequencing creates an upfront cost in screening patients for MRSA, a new study finds that it’s a cost-effective way to prevent new infections and related deaths.
Utilizing MRSA Nasal Screening for Antimicrobial Stewardship
This In the Literature piece details a study evaluating MRSA nasal screening’s effect on antimicrobial stewardship.
Can Cannabidiol Fight Drug-Resistant Gram-Positive Bacteria?
Australian investigators conducted an assessment to determine if cannabidiol was effective at killing a range of gram-positive bacteria.
Multiple Site Testing for MRSA Carriage Increases Detection by 25%
The research team used single site testing for 1442 (32%) patients with 54 positive (4%) results. Multiple site testing was performed on 3037 (68%) patients and 255 (8%) were positive from at least 1 site tested.
The Great Debate: Combination or Monotherapy for Prolonged MRSA Bacteremia?
De-escalation to monotherapy upon bacteremia resolution did not result in unfavorable outcome differences compared with those who continued combination therapy.
Optimal Vancomycin Dosing in Obese Patients: Moving Toward the AUC
This In the Literature piece explores if we can mitigate some of the adverse reactions that are being seen in obese patients who receive vancomycin through AUC-dosing.
Discontinuing Contact Precautions for MRSA, VRE Did Not Affect HAI Rates, Study Finds
The aggregated average HAI rates before and after discontinuing contact precautions were 0.14 and 0.15 MRSA HAI/1000 patient days, 0.06 and 0.04 VRE HAI/1000 patient days, and 0.04 and 0.03 MRSA LabID events/100 admissions.
Should We Cut Back on Chlorhexidine Bathing?
A new study showed no statistically significant reduction in clinical cultures between chlorhexidine bathing and routine care.
Delafloxacin Non-Inferior to Vancomycin/Aztreonam for ABSSSI in Pooled Phase 3 Analysis
Delafloxacin was comparable to vancomycin/aztreonam in eliminating MRSA at 98.1% versus 98.0%, respectively, at follow-up in 2 pooled phase 3 studies.
Can Cockroaches in Hospital Environments Harbor MRSA?
A new study of cockroaches collected from an Iranian hospitals sheds light on how these insects can carry and spread resistant microbes.
Cutting MRSA Infections Post-Discharge
Post-discharge decolonization education and bioburden reduction could be critical to reducing MRSA infections.
Are We Taking a Step Back in Staph?
Staph infections aren't going away and now a new report says we're not doing as well as we think.
Ibuprofen Shows Promise in Controlling S aureus
Ibuprofen succeeded in fighting S aureus in a laboratory setting, although it’s not clear whether the same effect would hold true in patients with systemic infections.
Use of Genomic Surveillance Helps Identify Hidden MRSA Outbreak
Applying hospital-based outbreak tools helped researchers identify a community MRSA outbreak
Antibiotic Cycling Not Linked to Lower MRSA, C Diff Incidence
Antibiotic cycling is not linked to a reduced incidence of health care-associated MRSA or Clostridium difficile infection, a new study shows.
The Multi-Drug Resistant Organism Network
A collaborative, international effort aims to answer tough antimicrobial resistance questions.
Nuts and Bolts of Twitter for Antimicrobial Stewardship
Use of Twitter to Educate and Engage Surgeons in Antimicrobial Stewardship
Case Studies of Effective Twitter Use in Medicine
Transferring Social Media Best Practices From Oncology to Antimicrobial Stewardship
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