March 18th 2024
In the latest issue, Editor-in-Chief Jason Gallagher, PharmD, FCCP, FIDP, FIDSA, BCPS, discusses the continuous antibiotic trade-off of targeted vs broad spectrum therapies and cheap vs expensive options as they relate to UTI treatment.
FDA Issues a CRL for Venatorx Pharmaceuticals’ Antibiotic for Treatment of Complicated UTI
February 23rd 2024The federal agency did not request further trials for the investigational therapy, cefepime-taniborbactam, but wanted more information about its chemistry, manufacturing, and controls.
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Investigational Antibiotic Outperforms Meropenem in Treating Complicated UTI
February 16th 2024A recently published study demonstrated the superior efficacy of cefepime–taniborbactam over meropenem for managing complicated urinary tract infections, suggesting a promising treatment option amid rising antibiotic resistance challenges.
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Are We at a Breaking Point for Adoption of Updated Susceptibility Interpretive Criteria?
November 28th 2023The implementation of new College of American Pathologists rules presents an opportunity for collaboration between clinical microbiology laboratories and infectious disease pharmacists and physicians.
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Antibiotic De-Escalation: Is This the Right Outcome Measure?
November 16th 2023The proposed clinical benefits of de-escalation has contributed to its lukewarm adoption in some settings. This article looks at the challenges in measuring the impact of de-escalation, and the ongoing search for more meaningful metrics to evaluate the success of antimicrobial stewardship (AMS) programs.
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Two Pragmatic Approaches to Skin and Soft Tissue Infections
November 14th 2023Empirical antibiotic therapy in diabetic foot ulcer infections increases hospitalization and prolonged symptoms in patients being treated for lower limb cellulitis are common. Two recent papers examine the need for effective communication, the importance of objective findings in cellulitis management, and the benefits of culture-based antibiotic therapy in diabetic foot ulcer cases.
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Outpatient Antimicrobial Stewardship: The Keys to Developing a Successful Program
This form of stewardship can reduce unnecessary antibiotic prescribing, reduce costs, and optimize patient outcomes.
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A Neglected Issue: Mechanical Ventilation and Drug-Resistant Pathogen Burden
October 29th 2023A new study highlights the growing threat of drug-resistant pathogens, particularly in healthcare settings, and underscores the need for enhanced surveillance and intervention strategies to combat these emerging and resistant infectious diseases.
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