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Top 5 Contagion® News Articles for the Week of September 17, 2017


#5: New Treatment for CABP Continues to Show Positive Outcomes in Clinical Trials

The leading cause of infectious disease death in the United States is community-acquired bacterial pneumonia (CABP), with more than 5 million adults being treated for the disease each year. The infection is the second highest cause of hospital admissions through the emergency room and because the infection can be severe and potentially life-threatening, many patients end up being readmitted for further treatment. The estimated hospitalization costs to treat the infection are $17 billion. Thus, research and development aimed at a treatment for the infection are booming, and one such company has made an important step forward to bringing a treatment to market.

The clinical-stage biopharmaceutical company, Nabriva Therapeutics, just released positive top-line global Phase 3 trial data on their intravenous (IV) and oral forms of a pleuromutilin antibiotic, lefamulin, for the treatment of community-acquired bacterial pneumonia (CABP) today. The drug met all primary US Food and Drug Administration (FDA) and European Medicines Agency (EMA) endpoints. In this exclusive interview, with Contagion®, Thomas File, MD, MSc, Chair of Infectious Disease Division, Summa Health in Akron, Ohio, explains what pleuromutilin antibiotics are and how they work.

Read more about the new CABP treatment, here.

#4: US Government Launches Aggressive New Strategy to Accelerate HIV/AIDS Epidemic Control

Today, September 19, 2017, US Secretary of State, Rex Tillerson, revealed the new the US President’s Emergency Plan for AIDS Relief (PEPFAR) Strategy for Accelerating HIV/AIDS Epidemic Control (2017-2020). This new plan comes on the heels of new Population-based HIV Impact Assessments (PHIA) data from the PEPFAR which shows that 5 African countries are on the brink of fully controlling the HIV epidemics in their countries. Malawi, Swaziland, Zambia, and Zimbabwe are the first 4 countries, and now, new data reveals that Lesotho can be added to the list.

In Lesotho, the newest country added to the list, over 67% of all HIV-positive adults ages 15-59 have been able to achieve viral load suppression, according to the latest PHIA results. These data suggest that the country is well on its way to hit the 90-90-90 targets set forth by the Joint United Nations Programme on HIV/AIDS (UNAIDS) by 2020. PHIA data from 7 additional countries are still being collected and is set to be revealed on a rolling basis through 2017 to 2019.

Read more about the strategy, here

Big advances in treatment can