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Latest:
Immunocore Reports Some PWH Achieve Viral Control and Dose-Dependent Active HIV Reservoir Reduction in IMC-M113V TrialDavid Berman, MD, PhD, discusses signs of dose-dependent viral control and reduction in active HIV reservoir in Phase 1/2 STRIVE trial data.
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The CM Study: Bivalent HIV Vaccine Induces Stronger T Cell Responses in People with HIV on ARTNilu Goonetilleke, LLBHons, BScHons, PhD, presents findings showing the bivalent HIVconsvX vaccine targets both Mosaic-1 and Mosaic-2, resulting in broader immune responses.
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Political and Social Barriers to Ending the HIV EpidemicLearning about these barriers is the first step to overcoming them.
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A Passion for Infectious Disease Education and CommunicationIn our latest podcast, Tim Gauthier, PharmD, BCPS, BCIDP, discusses all things pathogens and antibiotics. He also details the opportunities presented for antimicrobial stewardship when it combines diagnostics and treatment duration.
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A Late-Stage Tuberculosis Vaccine is Making its Way Through Clinical TrialsMonday is World Tuberculosis (TB) Day, and a vaccine developed by the Gates Medical Research Institute is being studied in a phase 3 trial. If approved, the vaccine could potentially prevent pulmonary TB in adults and adolescents.
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CRAB-By No More?Understanding the potential and limitations of new Acinetobacter baumannii active therapies.
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A Comparative Analysis Show Distinct Severity of COVID-19 vs InfluenzaResults of a study by Yan Xie and colleagues highlight the severe impact of COVID-19, with higher death rates, increased risks of long-term complications, and greater infectivity compared to seasonal influenza.
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Addressing Antimicrobial Resistance in WomenUzma Syed, MD, DO discussed how various factors increase women’s susceptibility to AMR, the importance of policies, and the need for culturally specific education and advocacy to improve health outcomes.
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Fungal Biofilm-Related Diseases: Diagnosis, Treatment, and Emerging ChallengesProfessor Gordon Ramage, BSc, PhD, discusses the increasing impact of fungal biofilms, new treatment options, and the need for enhanced detection methods.
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Analyzing Household Transmission of COVID-19At ID Week 2024, an investigator, Amanda M. Casto, MD, PhD, discusses her work on the CASCADIA study, which examined infection rates in this setting, and how it challenged assumptions that there is likely a singular carrier bringing viruses into homes.
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Timeline for mRNA Vaccine Development for Rift Valley FeverCaryn Fenner and Petro Terblanche outline Afrigen's clinical trial plans, local partnerships, and vaccine pipeline.
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Nationwide Avian Flu Response Gains Momentum, Yet Urgent Action Remains EssentialThe ongoing H5N1 avian flu outbreak has severely impacted U.S. poultry and dairy industries, prompting a $1 billion USDA response strategy that includes biosecurity, vaccination research, and innovation funding. With growing concern over viral mutations affecting humans and livestock, rapid, field-based diagnostic tools offer critical support in accelerating detection and containment efforts.
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Federal Government Changes Course Again on COVID-19 Vaccine PolicyAfter the leaders of the NIH, FDA, and HHS made an announcement stating that both pregnant women and children were going to be taken off the COVID-19 immunization schedule, they decided to offer a new designation for the latter group, making it a shared decision between providers and patients.
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Tricky Infusion Issues and Potential Solutions: OPAT EditionOutpatient parenteral antimicrobial therapy (OPAT) offers benefits for patients as well as providing cost effectiveness; however, it is not without its challenges. Two clinicians provide insights on this modality.
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Apretude PrEP Shows High Efficacy, Safety in Diverse StudiesNew data at CROI 2025 shows zero cases of HIV acquisition reported with Apretude (cabotegravir long-acting (CAB LA) for PrEP in varied clinical settings and populations in 2 implementation studies in the US and Brazil.
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Antimicrobial Stewardship: How to Extend a Solid HandshakeIn the latest column from SIDP, handshake stewardship prioritizes face-to-face communication between frontline providers to enable feedback to assess the appropriateness of prescribed antimicrobials.
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Expanding Tick-Borne Disease Trends in New JerseyEvelyn Wu, MD, reveals a rise in tick-borne diseases in New Jersey over the past two decades and correlations with the influence of warming climate conditions.
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Shifting to Shorter Courses of Antibiotic Therapy for Common Pediatric InfectionsIn the latest SIDP column, two clinicians provide information on recent studies and guidelines directed at antibiotic durations in this patient population.
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A Case of Hemophagocytic Lymphohistiocytosis Secondary to Cytomegalovirus InfectionThere have been sporadic cases Hemophagocytic Lymphohistiocytosis, associated with Cytomegalovirus Infection infection, suggesting that CMV may cause clinically significant disease beyond mononucleosis in immunocompetent individuals.
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Impact of Inpatient Pharmacist Review of Discharge AntibioticsA food for thought as an ambulatory antibiotic stewardship initiative.
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Evaluating the Efficacy of Paxlovid in High-Risk Patients with Pre-Existing ImmunityJohn McLaughlin, PhD, examines high-risk individuals with prior SARS-CoV-2 immunity and presents that Paxlovid reduces the risk of hospitalization, death, and severe symptoms, highlighting its ongoing value for high-risk patients in a post-peak pandemic landscape.
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Vowst Maintains Consistent Safety Profile in rCDI Patients With ComorbiditiesAt MAD-ID, Dianne Nguyen, MD, shares Phase 3 data showing consistent tolerability of the microbiome therapy across high-risk patient populations
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The Escalating Challenges of Gram-Resistant Organisms: The Role of CefiderocolClinical trial and real-world data, including the PROVE study, support its role as an effective and carbapenem-sparing therapy for serious infections, though outcomes vary depending on pathogen and infection type.
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Considerations for Antimicrobial Stewardship While Optimizing Therapy for a Patient With HIVHere is a case study involving a patient with the virus and the clinical approach in thinking about appropriate treatment while keeping stewardship in mind.
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Internal Tremors: Adding to the List of Long COVID SymptomsInternal tremors are a newly recognized and troubling symptom of Long COVID, experienced by over one-third of participants in a Yale-based study
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Discussing Outpatient COVID-19 TreatmentsHere is a look at some of the treatment alternatives, which can offer simpler logistics and cost considerations.
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The Role of Rifampin in Bone and Joint InfectionsIn the latest column from the Society of Infectious Diseases Pharmacists (SIDP), here is a discussion on the use of rifampin as an adjunctive antibiotic treatment for patients with diabetic foot osteomyelitis.
