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Clinicians Discuss the State of Vaccines TodayA panel discusses how vaccine policy under new federal government policies, why misinformation has flourished and what individual providers can do to win back patient trust.
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What We Know But Still Have to Learn About Long COVIDDespite advances in understanding and treating Long COVID, many questions about its mechanisms, susceptibility, and varied recovery patterns remain unresolved, underscoring the need for continued research.
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Resources Available for Patients with HIV Drug ResistanceThe panel concludes its discussion by talking about resources available for providers in managing their patients with HIV who experience drug resistance.
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Examining RSV Vaccines for SeniorsTwo RSV vaccines for seniors were FDA approved this year and here is an overview of the vaccines and the study data.
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When Should We De-Escalate Empiric Antimicrobials?De-escalating empiric antimicrobial therapy is a strategy to combat antimicrobial resistance. Antimicrobial stewardship programs can play a major role in preserving antibiotic effectiveness and preventing unnecessary antibiotic use.
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Expanding HIV Prevention: Overcoming Barriers and Embracing Long-Acting PrEPZandraetta Tims-Cook, MD, MPH, highlights the need for inclusive HIV prevention strategies and discusses the potential of long-acting injectable PrEP in improving care and reducing disparities.
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Practical Strategies to Minimize Antimicrobial Resistance in Critically Ill PatientsPranita Tamma, MD, MHS, continues her conversation about a study she was involved in that compared ceftolozane-tazobactam and ceftazidime-avibactam. She discusses how clinicians can help reduce the emergence of antimicrobial resistance by using higher doses with extended infusions, limiting treatment duration, ensuring source control, and avoiding unnecessary dose reductions during CRRT.
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IDSA Guidance on the Treatment of Antimicrobial Resistant Gram-Negative InfectionsSince late 2004, 7 novel antibiotics with activity against ESBL-E, CRE, and/or DTR P aeruginosa have been approved.
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Examining Disparities in HIV Mortality That Remain UnderexaminedSohaib Asghar, MBBS, MD, highlights the role of socio-economic factors and demographic disparities in HIV mortality from 1999 to 2023.
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Wiki-What? Navigating WikiGuidelines and Leveraging Their AdvantagesWikiGuidelines produces novel clinical practice guidelines developed with pragmatic, applicable methodology, including a diverse author group.
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Retinal Biomarkers Reveal Vascular Changes in Long COVIDManjot K Gill, MD, MS, FASRS, FRCS(C), discusses how reduced retinal capillary perfusion may provide insights into Long COVID’s neurological effects and potential treatment approaches.
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5 Strategies for Improving Sepsis Care ManagementHospitalists can be better equipped to identify patients most in need of intervention and standardize sepsis management efforts.
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Targeted Prophylaxis Reduces Hospital-Onset C difficile Infections in High-Risk PatientsThe STOP-CDI intervention presented by Matthew J.Ziegler, MD MSCE revealed using prophylactic enteral vancomycin, significantly reduced hospital-onset C difficile infections among immunocompromised patients.
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Climate Change Effects on Vector-Borne Disease: The Case of LymeWith evolving weather patterns, the natural habitat of ticks is expanding, and more people are becoming susceptible to them.
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Backpack Science: Enabling Realtime Work in the Field for Genomic Testing of Infectious DiseasesGathering data in the field, especially when it relates to infectious disease may have potentially profound implications for research because it enables scientists to generate valuable data quickly and efficiently without having to be in a laboratory setting.
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Stronger Than Yesterday: Decreased Hospital Readmissions After Strengthening of an OPAT ProgramAlthough close clinician monitoring is warranted to avoid complications for this this type of treatment, it can be beneficial to patients and help reduce care costs.
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What Role Should Scientists, Clinicians Play With Mirror Life Policy, Public CommunicationIn part 2 of the conversation, David Relman, MD, discusses the importance of the research and medical communities in shaping future work in this area as well as the potential severe consequences of Mirror Life in a worse case scenario.
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Vancomycin AUC Implementation in Resource-Limited Settings and its Associated DifficultiesThe latest article from SIDP illustrates the challenges of area under the curve (AUC) implementation and offers insights for strategies and resources to overcome them.
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Multidrug Resistance in a Patient With HIVIn this case study, clinicians review a challenging case.
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Daptomycin Resistance Among Enterococci Is a Growing Antimicrobial Resistance ThreatIn a world heavily focused on therapeutic options for multidrug-resistant gram-negative organisms, the emergence of antimicrobial resistance among enterococci is often an under-recognized risk.
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Novavax vs mRNA Vaccines: Understanding Vaccine ReactogenicityNovavax Vice President Matthew Rousculp on reactogenicity, vaccine hesitancy, and supporting informed decisions.
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Findings From Screening Study for Hepatitis B and Hepatitis D Demonstrate Need for Follow-Up TestingIn our latest podcast, first author Elizabeth Marlowe, PhD, D(ABMM), offers insights on her study looking at this ongoing issue, including the need for increased testing and getting patients into the continuum of care in a more efficient manner.
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Initial Findings from IMC-M113V Trial for HIV Functional Cure Strategy Shows PotentialBeatriz Mothe, MD, PhD discusses the Phase 1/2 STRIVE trial of IMC-M113V, a T cell receptor bispecific therapy targeting HIV-infected cells
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Complicating the Uncomplicated: A Bundled Approach to Reducing Inappropriate Antibiotic Prescribing for Acute Uncomplicated BronchitisA recent study evaluated bundled ambulatory stewardship interventions (ASIs) — audits, reporting, webinars, and electronic alerts — to reduce inappropriate antibiotic prescriptions (IAPs) for acute uncomplicated bronchitis (AUB).
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A Case of Candida Albicans Ventriculitis Secondary to E Coli Ventriculoperitoneal Shunt InfectionRare cases of health care–associated meningitis and ventriculitis in adults caused by Candida species are associated with recent bacterial meningitis and broad-spectrum antibiotic use.
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Children, COVID-19, and Another Crazy Respiratory Viral SeasonKevin J. Downes, MD, and Contagion® Section Editor Conan MacDougall, PharmD, MAS, BCPS, BCIDP, discuss these important topics as another season approaches.
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No Shortcuts With C difficile: What Electronic Hand Hygiene Reminders Tell Us About Hand Washing PreventionC difficile remains a major healthcare-associated infection. Despite clear guidelines, hand hygiene compliance often falls short, creating gaps between policy and practice. A case study from a hospital showed that after implementing an electronic hand hygiene monitoring system with behavior prompts, compliance improved.
