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Streptococcus Pneumoniae Bacteremia Secondary to Community-Acquired Pneumonia: Another Case of Shorter Is Better?

Study questions whether reducing antibiotic treatment duration for pneumococcal bacteremia still ensures effective outcomes and minimizes risks.

The Promise of Lenacapavir in the Current Era

This newly approved long-acting injectable PrEP offers 6 months of HIV protection, and represents a major scientific and policy breakthrough. However, its success will depend on ensuring equitable access, enforcing coverage requirements, and maintaining a robust, multi-faceted HIV prevention infrastructure amid political and systemic challenges.

From Poultry to Public Health: Understanding the H5N1 Threat

Veterinary and public health officials share the important roles of surveillance and prevention strategies, insights on the virus's transmission pathways, historical context, the One Health approach, and highlights effective precautionary measures to mitigate H5N1 risks.

A Dose of Clarity: Low- vs High-Dose Trimethoprim-Sulfamethoxazole for Stenotrophomonas maltophilia Pneumonia

Findings from a recent study challenge the need for high-dose trimethoprim-sulfamethoxazole in managing Stenotrophomonas maltophilia pneumonia, finding lower doses may offer comparable efficacy.

The Changing Climate of Vector-Borne Diseases

These types of infections will continue to rise, and there is a need to understand what we are witnessing and find ways to combat them.

When Daptomycin Fails: Practical Approaches to Resistant Enterococcus faecium

Daptomycin-resistant Enterococcus faecium bacteremia is an emerging, high-mortality challenge in transplant and other high-risk patients, requiring early recognition, aggressive source control, and reliance on limited alternatives—most notably linezolid—with combination or salvage therapies considered when options are constrained.

This Is the “Weight” Forward: GLP-1 Use in HIV Care

Here is a review of glucagon-like peptide-1 receptor agonist use in people with HIV.

Precision in Practice: PK/PD Modeling Advances Infectious Disease Care

At MAD-ID, Marc Scheetz, PharmD, discusses how PK/PD modeling and AUC-based strategies offer safer, more precise antibiotic therapy.

Tuberculosis Meningitis in an Immunocompetent Patient

Read more about the case of a 71-year-old man who was admitted after presenting with cold-like symptoms for 3 weeks.

How Typhoid Fever Triggers Severe Neurological Symptoms

Yale researchers have discovered how typhoid fever triggers neurological symptoms, offering new insight into treatment options.

A No-Carb Diet: An Overview of Non–Carbapenemase-Producing Carbapenem-Resistant Enterobacterales

Non–carbapenemase-producing carbapenem-resistant Enterobacterales (CRE) isolates are the most common mechanism of CRE in the United States, but the optimal antimicrobial treatment remains to be elucidated.

STAY PrEPARED: Understanding COVID-19 Pre-Exposure Prophylaxis

New therapeutics offer some hope in this emerging market.

Protectors vs Police: How Antimicrobial Stewardship Interventions Come Across and How to Change the Narrative

How stewardship teams communicate determines whether interventions feel like policing or collaboration. Using structured, data-driven frameworks— advocacy-inquiry-listen-teach and DART—creates psychological safety to explore understanding and supports shared decision-making.

Unlocking New Defenses: The Changing Landscape of Candida auris Management

Candida auris is a highly drug-resistant, hospital-acquired fungal pathogen. With limited treatment options, here is an overview of some of the next-generation antifungals as well as combination therapeutics.

Using the NARROWS Framework to Improve Antibiotic Stewardship: A Communication Tool for Hospital Clinicians

The NARROWS framework, developed within the IDSA Core Antimicrobial Stewardship Curriculum, provides a structured, behaviorally informed approach to communication that helps stewardship teams address the social, emotional, and cultural factors influencing prescribing decisions in order to optimize antimicrobial use and combat resistance.

Bordetella bronchiseptica Clinical Application and Treatment Review

Bordetella bronchiseptica is a rare human respiratory pathogen that can be initially confused for Bordetella pertussis, leading to potentially inadequate treatment. This article reviews the organism and recent literature on the successful treatment of B bronchiseptica.

Tuberculosis Meningitis in an Immunocompetent Patient

Read more about the case of a 71-year-old man who was admitted after presenting with cold-like symptoms for 3 weeks.

Beyond Approval: Finding the Right Place for Emerging Gram-Negative Antibiotics

The expanding gram-negative antibiotic pipeline offers important new treatment options; however, FDA approval alone does not define a drug’s place in therapy. Clinicians must weigh the clinical problems that each agent solves, the strength of the evidence behind it, and what remains unknown before incorporating these therapies into routine practice.

Tuberculosis Meningitis in an Immunocompetent Patient

Read more about the case of a 71-year-old man who was admitted after presenting with cold-like symptoms for 3 weeks.

From Allies to Adversaries: Antibiotics and Their Influence on Gut Microbiome

Systemic antibiotic therapy often leads to significant long-term disruptions to the gut microbiome. In addition to antibiotic stewardship, use of prebiotic fiber, fermented foods, and probiotics is a recommended strategy to minimize microbiome disruption and reestablish a healthy, diverse gut microbial population.

Daptomycin Resistance Among Enterococci Is a Growing Antimicrobial Resistance Threat

In a world heavily focused on therapeutic options for multidrug-resistant gram-negative organisms, the emergence of antimicrobial resistance among enterococci is often an under-recognized risk.

Measles: An Old Foe Has Returned

Texas is experiencing its largest measles outbreak in 30 years and the Centers for Disease Control and Prevention's (CDC) Epidemic Intelligence Service is providing support there. Here is an overview on testing, disease presentation, and vaccination, as well as commentary on the public health impact of vaccine hesitancy, and the unintended consequences of the immunization program’s success.

Daptomycin Resistance Among Enterococci Is a Growing Antimicrobial Resistance Threat

In a world heavily focused on therapeutic options for multidrug-resistant gram-negative organisms, the emergence of antimicrobial resistance among enterococci is often an under-recognized risk.

The Aminoglyco-Side Hustle: What’s Now and Next in Gram-Negative Infections

In the midst of many changes surrounding aminoglycosides over the past several years, clinicians may be left wondering if these agents still have a role in modern clinical practice. This article summarizes changes impacting aminoglycosides, discusses where these agents may still have a role in the context of gram-negative infections, and explores future areas of study.

The Potential for Antivirals in Dengue Prophylaxis and Treatment

A study found that the investigational antiviral mosnodenvir reduced dengue virus infection RNA levels and symptoms in a controlled setting, supporting its potential as a prophylactic option.

Is Renal-Adjusted Ceftazidime/Avibactam in Patients With KPC-Producing Klebsiella Pneumoniae Bloodstream Infection Associated With Increased Mortality?

Can AI Solve the Skills Shortage in Antimicrobial Stewardship?

A recent literature review describes the current state of artificial intelligence tools for guiding antimicrobial therapy. Are you ready for change?

Dose Optimization as a Strategy to Improve Clinical Outcomes and Suppress Antimicrobial Resistance

From the discovery of penicillin to PK-PD principles: A brief historical overview and what we have learned from recent clinical trials.

Redefining HIV Management: Emerging Antiretroviral Drug Classes and Immunologic Strategies Shaping the Future of HIV Treatment, Prevention

Several combination products are currently in development for people with HIV. Here is a review of these treatments.

COVID-19: The Gaps in Science Communication

The COVID-19 pandemic intensified long-standing problems in scientific production and communication—driven by perverse academic incentives, peer review strain, media hype, and growing misuse of AI—highlighting the urgent need for stronger critical appraisal skills across research and medicine.