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Streptococcus Pneumoniae Bacteremia Secondary to Community-Acquired Pneumonia: Another Case of Shorter Is Better?

Study questions whether reducing antibiotic treatment duration for pneumococcal bacteremia still ensures effective outcomes and minimizes risks.

The Promise of Lenacapavir in the Current Era

This newly approved long-acting injectable PrEP offers 6 months of HIV protection, and represents a major scientific and policy breakthrough. However, its success will depend on ensuring equitable access, enforcing coverage requirements, and maintaining a robust, multi-faceted HIV prevention infrastructure amid political and systemic challenges.

From Poultry to Public Health: Understanding the H5N1 Threat

Veterinary and public health officials share the important roles of surveillance and prevention strategies, insights on the virus's transmission pathways, historical context, the One Health approach, and highlights effective precautionary measures to mitigate H5N1 risks.

The Changing Climate of Vector-Borne Diseases

These types of infections will continue to rise, and there is a need to understand what we are witnessing and find ways to combat them.

Precision in Practice: PK/PD Modeling Advances Infectious Disease Care

At MAD-ID, Marc Scheetz, PharmD, discusses how PK/PD modeling and AUC-based strategies offer safer, more precise antibiotic therapy.

Tuberculosis Meningitis in an Immunocompetent Patient

Read more about the case of a 71-year-old man who was admitted after presenting with cold-like symptoms for 3 weeks.

How Typhoid Fever Triggers Severe Neurological Symptoms

Yale researchers have discovered how typhoid fever triggers neurological symptoms, offering new insight into treatment options.

STAY PrEPARED: Understanding COVID-19 Pre-Exposure Prophylaxis

New therapeutics offer some hope in this emerging market.

Using the NARROWS Framework to Improve Antibiotic Stewardship: A Communication Tool for Hospital Clinicians

The NARROWS framework, developed within the IDSA Core Antimicrobial Stewardship Curriculum, provides a structured, behaviorally informed approach to communication that helps stewardship teams address the social, emotional, and cultural factors influencing prescribing decisions in order to optimize antimicrobial use and combat resistance.

Bordetella bronchiseptica Clinical Application and Treatment Review

Bordetella bronchiseptica is a rare human respiratory pathogen that can be initially confused for Bordetella pertussis, leading to potentially inadequate treatment. This article reviews the organism and recent literature on the successful treatment of B bronchiseptica.

Tuberculosis Meningitis in an Immunocompetent Patient

Read more about the case of a 71-year-old man who was admitted after presenting with cold-like symptoms for 3 weeks.

Tuberculosis Meningitis in an Immunocompetent Patient

Read more about the case of a 71-year-old man who was admitted after presenting with cold-like symptoms for 3 weeks.

Daptomycin Resistance Among Enterococci Is a Growing Antimicrobial Resistance Threat

In a world heavily focused on therapeutic options for multidrug-resistant gram-negative organisms, the emergence of antimicrobial resistance among enterococci is often an under-recognized risk.

Measles: An Old Foe Has Returned

Texas is experiencing its largest measles outbreak in 30 years and the Centers for Disease Control and Prevention's (CDC) Epidemic Intelligence Service is providing support there. Here is an overview on testing, disease presentation, and vaccination, as well as commentary on the public health impact of vaccine hesitancy, and the unintended consequences of the immunization program’s success.

Daptomycin Resistance Among Enterococci Is a Growing Antimicrobial Resistance Threat

In a world heavily focused on therapeutic options for multidrug-resistant gram-negative organisms, the emergence of antimicrobial resistance among enterococci is often an under-recognized risk.

The Aminoglyco-Side Hustle: What’s Now and Next in Gram-Negative Infections

In the midst of many changes surrounding aminoglycosides over the past several years, clinicians may be left wondering if these agents still have a role in modern clinical practice. This article summarizes changes impacting aminoglycosides, discusses where these agents may still have a role in the context of gram-negative infections, and explores future areas of study.

Is Renal-Adjusted Ceftazidime/Avibactam in Patients With KPC-Producing Klebsiella Pneumoniae Bloodstream Infection Associated With Increased Mortality?

Can AI Solve the Skills Shortage in Antimicrobial Stewardship?

A recent literature review describes the current state of artificial intelligence tools for guiding antimicrobial therapy. Are you ready for change?

Dose Optimization as a Strategy to Improve Clinical Outcomes and Suppress Antimicrobial Resistance

From the discovery of penicillin to PK-PD principles: A brief historical overview and what we have learned from recent clinical trials.

Ocular Syphilis and Neurosyphilis in a Patient Living With HIV

Undermining HIV Prevention Now Will Cost Billions Later

The 15th anniversary of the Affordable Care Act is overshadowed by threats to HIV prevention efforts, including a looming Supreme Court case that could eliminate no-cost access to preexposure prophylaxis and other preventive services. Simultaneously, deep federal cuts and restructuring have destabilized critical public health infrastructure, jeopardizing decades of progress in the fight against HIV.

Follow the Science: Why CD4 Testing Is Critical in the Fight Against HIV/AIDS

To meet ambitious targets for ending the HIV/AIDS epidemic, governments must unite in a global effort to improve access to CD4 testing.

The Consequences of Doxycycline Postexposure Prophylaxis

Doxycycline postexposure prophylaxis is associated with emerging tetracycline resistance in Neisseria gonorrhoeae and commensal organisms, highlighting the need for cautious, targeted use.

Now is Not the Time for Funding Pauses, Cutting Ties With Health Organizations

Biocontainment, including the most recent threat of highly pathogenic avian influenza, demands we continue to finance research, and continue cooperation with important organizations like the WHO.

When Should We De-Escalate Empiric Antimicrobials?

De-escalating empiric antimicrobial therapy is a strategy to combat antimicrobial resistance. Antimicrobial stewardship programs can play a major role in preserving antibiotic effectiveness and preventing unnecessary antibiotic use.

When Should We De-Escalate Empiric Antimicrobials?

De-escalating empiric antimicrobial therapy is a strategy to combat antimicrobial resistance. Antimicrobial stewardship programs can play a major role in preserving antibiotic effectiveness and preventing unnecessary antibiotic use.

Respiratory Syncytial Viral Infection: Treatment With Ziresovir in Infants

Findings from a recent phase 3 trial show promising results for the approval of ziresovir in the treatment of respiratory syncytial virus in infants.

Updates in the Treatment of Mycobacterium Tuberculosis

The latest Bench to Bedside column reviews new guidance on the treatment of drug-susceptible and drug-resistance Mycobacterium tuberculosis infections.

Comparing The Environmental Impact of Inpatient IV Antimicrobial Administration With OPAT

Environmental modeling shows inpatient IV therapy has the highest carbon, water, and waste footprint, while OPAT offers major reductions.

What is Driving the Global Expansion of Lyme Disease?

Climate-driven changes and other drivers of the expanding geographic range of Ixodes ticks and Lyme disease are explored.