January 27th 2023
The week's most-clicked COVID-19 stories included vaccine updates, new variants, and a pivotal FDA advisory committee vote.
Novavax will update its protein-based COVID-19 vaccine, but maintains the current vaccine is effective against current and future variants.
January 26th 2023
The FDA’s Vaccines and Related Biological Products Advisory Committee (VRBPAC) voted to move toward a unified strain composition for COVID-19 primary and booster vaccines.
In the CDC’s latest Morbidity and Mortality Weekly Report, investigators reported the Moderna and Pfizer-BioNTech updated vaccines helped prevent acute infection from the latest Omicron mutations.
The Pfizer-BioNTech COVID-19 vaccine was associated with rare instances of myo/pericarditis and acute kidney injury, according to a nationwide study in New Zealand that confirmed the safety profile of the vaccine.
Novavax COVID-19 Vaccine Neutralizes Omicron Mutations
A new study demonstrated continuous neutralization after 3 doses.
Omicron Variant of COVID-19 Linked to Worse Maternal Outcome in Pregnant Women
“Vaccination coverage among pregnant women remains a priority,” the study authors noted.
Ahead of FDA VRBPAC, a Glimpse of COVID-19 Vaccine Changes
In this week’s meeting, FDA is expected to ask their advisory committee to consider changes to simplify the vaccination schedule and look at delivering it annually, much like an influenza vaccine.
Does Vaccination Before or After Infection Prevent Long COVID?
What factors contribute to post-COVID-19 conditions (“long COVID”)? Can vaccination before or after a COVID-19 infection decrease the risk of long COVID?
Americans Report Their Top Reasons for Not Receiving a Bivalent Booster
Reported reasons adults had not received a bivalent COVID-19 booster dose differed across age groups.
Comparing Pediatric COVID-19 Disease Severity Across Variants
Children were hospitalized the most during the Omicron variant, but disease outcomes were the least severe during this variant period.
Can Exercise Protect Against Severe COVID-19?
A retrospective study showed that exercise was found to have a protective association to adverse COVID-19 outcomes.
IL-6 Inhibitors, Antiplatelets Improve Survival of Critically Ill COVID-19 Patients
Interleukin-6 receptor antagonists and antiplatelets are highly likely to improve long-term survival of critically ill adults with COVID-19, a recent study suggests.
PREP Act Set to Sunset in 2024 Affecting Half of US States
This act designed to allow pharmacists and technicians the ability to administer certain vaccines without a prescriber order will lapse next year. A new report looks at vaccination trends in the US and how pharmacists are playing a vital role in administering vaccines.
High Mucosal Antibodies in Airways Reduce COVID-19 Reinfection by 55%
High levels of mucosal IgA antibodies in the airways were found to protect against COVID-19 reinfection for at least 8 months.
Bivalent COVID-19 Booster Vaccination for Children Still Recommended After Safety Review
A CDC report looked at 2 vaccine safety surveillance systems for the bivalent boosters in this population and there were no reports of myocarditis or death. Many of the reports were due to vaccine errors and not adverse events.
CDC, FDA Announce Safety Signal Related to the Pfizer-BioNTech Bivalent COVID-19 Vaccine
The two agencies said one of the vaccine surveillance systems prompted an investigation into whether there was a safety concern for ischemic stroke in seniors for this booster.
COVID-19 Vaccinations Increased 5.2% This Year. Where Are They Still Lagging?
Good news: across 23 countries, trust in COVID-19 vaccines increased 5.2% from 2021 to 2022. However, vaccine hesitancy remains in key populations.
Moderna Provides Update on mRNA Vaccine Pipeline
The company is moving forward with vaccines to address respiratory and latent viruses as well as oncology.
The Year's Top COVID-19 Stories
New booster shots, antigen testing, and a shrinking incubation period: these were the top COVID-19 stories of 2022.
Why Aren’t We Better Protecting Our Youngest Children Against Infections?
Vaccinations and mitigations for COVID-19 and other respiratory viruses have not been made a priority for young children. Let’s change this before the next big surge hits.
FDA Announces Next VRBPAC Looking at Future of COVID-19 Vaccine Regimens
The committee will meet on January 26 to discuss whether and how the composition for primary doses of the currently available COVID-19 vaccines should be modified.
Bivalent Booster Provides Protection Against Severe COVID-19, Possible Hospitalization
In a new CDC report, these immunizations aid against emergency department and urgent care encounters in immunocompetent adults.
Blood-Related Syndrome Is Being Seen After Developing COVID-19 or Vaccination
Postural orthostatic tachycardia syndrome (POTS) is happening in people post-virus as well as within a 90-day period post-vaccination.
2 Years of the COVID-19 Vaccine: How Many Severe and Fatal Infections Have Been Prevented?
In addition to avoiding additional infection, illness, and death, the COVID-19 vaccination program likely saved the US $1.25 trillion in medical costs.
COVID-19 Mutations Render All Monoclonal Antibody Treatments Ineffective
The last available COVID-19 monoclonal antibody, bebtelovimab, is now no longer authorized due to suspected inability to neutralize the most dominant COVID-19 variants, Omicron BQ.1.1 and BQ.1.
FDA Authorizes Bivalent COVID-19 Vaccines for Children Down to 6 Months of Age
With an already overwhelming respiratory virus season with RSV and influenza, the hope is to prevent COVID-19 with these vaccines available to younger pediatric populations.
Pfizer-BioNTech Asks FDA to Authorize Omicron Bivalent COVID-19 Booster for Children Under 5 Years
Today, Pfizer-BioNTech filed submitted an Emergency Use Authorization (EUA) to administer their Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccine booster in children under 5 years of age.
Trial Tests Methods to Increase COVID-19 Vaccine Response in Kidney Transplant Recipients
Alternative strategies to increase immunogenicity of COVID-19 vaccines in immunosuppressed kidney transplant recipients are evaluated in clinical trial.
European Commission Approves Sanofi-GSK COVID-19 Booster VidPrevtyn
Sanofi and GlaxoSmithKline are the latest companies to bring their COVID-19 booster vaccine to the marketplace with the European Commission’s approval of VidPrevtyn Beta.
Pfizer-BioNTech Adapted Bivalent Booster Neutralizes Emerging Omicron Subvariants
New clinical findings suggest the Pfizer-BioNTech bivalent booster elicited more neutralizing antibody titers for all tested emerging Omicron sublineages, compared to their original COVID-19 vaccine.
Moderna Omicron-Targeting Booster Candidates Demonstrate Superiority Over its Spikevax Booster
Safety profile in this study showed the frequency of adverse reactions with these boosters were similar or lower than that of either a second or third dose of the original vaccine.
Phase 3 Trial of Vaxxinity’s COVID-19 Vaccine as a Heterologous Booster Advances
Vaxxinity is moving forward with research to bring its UB-612 COVID-19 vaccine to market as a mix-and-match booster to authorized vaccines.
COVID-19 Vaccine Boosters: Roadblocks, the Future, and Communicating the Benefits to Patients
“In the long run, what we will have is a virus that will become endemic in
our population," said Donald J. Alcendor, MD. "The idea of thinking we can chase variants with boosters is a failed effort. We must realize that.”
Long-COVID: How Common Is It?
The simple truth is that the long-lasting symptoms of COVID are something we should all be worried about.
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