|Videos|February 25, 2019

What is on the Horizon for HIV Prevention?

Ian Frank, MD, discusses the future of HIV prevention and long-acting injectables.

Segment Description: Ian Frank, MD, professor of medicine, Perelman School of Medicine, University of Pennsylvania, discusses the future of HIV prevention and long-acting injectables.

Interview transcript (modified slightly for readability):

Contagion®: Are there any news therapies on the horizon for PrEP?

Ian Frank, MD: “The most exciting medication on the horizon for PrEP is cabotegravir which is a long-acting injectable medication.

There's a large study going on right now, being sponsored by the HIV Prevention Trial Network, that compares injectable cabotegravir versus oral tenofovir disoproxil fumarate and emtricitabine, the currently US Food and Drug Administration (FDA)-approved PrEP regimen. Cabotegravir is being evaluated as an every 2-month injection. If it's effective in that way it would alleviate the need to adhere to a daily regimen and could really transform the ease of PrEP administration and engagement so there's a lot of interest in that particular study.”


Related to this article

Cefiderocol Continues to Show Activity Against Resistant Gram-Negative Infections
Shionogi data presented at IDWeek 2026 demonstrated a 76.7% clinical response with cefiderocol in carbapenem-resistant respiratory infections and high in vitro activity against resistant P aeruginosa VAP isolates. Christine Slover, PharmD, vice president, Infectious Diseases US Medical Affairs, Shionogi, offers insights on the data as well as clinical considerations for providers when weighing the antibiotic for patients.
Household Contacts Drive Most Hepatitis B Exposures in Young Children
Karen B. Jacobson, MD, MPH, of Kaiser Permanente Northern California, presented data at IDWeek 2026 showing 58.2% of children younger than five years exposed to active hepatitis B in the home were exposed by someone other than their birth mother, a risk maternal screening alone would miss under the CDC’s revised birth dose recommendation.
Inhaled Amikacin Shows Low Resistance Rates in MAC Lung Disease in ENCORE
In the phase 3b ENCORE trial, adding amikacin liposome inhalation suspension (ALIS) to azithromycin and ethambutol significantly improved culture conversion in newly diagnosed MAC lung disease, while treatment-emergent amikacin (2.2%) and macrolide (1.1%) resistance stayed rare. Kevin Winthrop, MD, provides insights around the study.