A healthy New Jersey man died from the allergy after eating red meat. Results from a blood sample collected post mortem found that he had been sensitized to the α-gal sugar, which is found in mammals. The blood sample results indicated the man had an extreme reaction, in line with what is seen in fatal anaphylaxis.
Investigators from the University of Virginia (UVA) School of Medicine in Charlottesville have identified the first death caused by what is commonly called the meat allergy being spread by Lone star ticks. A healthy 47-year-old man from New Jersey died abruptly 4 hours after consuming beef. The cause of his death had been a mystery until UVA Health’s Thomas Platts-Mills, MD, PhD, investigated. Platts-Mills discovered the allergy and remains the foremost expert on it. The allergy is caused by the bite of the Lone star tick. Bites can sensitize people to galactose-α-1,3-galactose (α-gal), a sugar found in mammalian meat. People who become sensitized to the sugar can have allergic symptoms such as rash, nausea, and vomiting after eating beef, pork, or lamb.1,2
“The important information for the public is, first, that severe abdominal pain occurring 3 to 5 hours after eating beef, pork, or lamb should be investigated as a possible episode of anaphylaxis,” Platts-Mills, former chief of UVA Health’s Division of Asthma, Allergy and Clinical Immunology, said in a statement. “On the other hand, most individuals who have mild to moderate episodes of hives can control symptoms with an appropriate diet.” 1
Scientists have feared that deadly anaphylaxis was possible in severe cases but had not confirmed a fatality from the allergy until now.
UVA researchers have confirmed the first fatal case of alpha-gal syndrome, caused by tick bites leading to red meat allergy.
The Lone Star tick is the primary vector spreading sensitization to alpha-gal, which can cause delayed anaphylaxis hours after eating beef, pork, or lamb.
Clinicians are urged to consider the condition in patients with unexplained allergic symptoms or severe abdominal pain following red meat consumption.
The case was published in The Journal of Allergy and Clinical Immunology: In Practice.2
The New Jersey man, whose name was not released, had gone camping with his wife and children in summer 2024. One night, they ate a late steak dinner at 10 PM. The man woke at 2 AM with severe abdominal pain, diarrhea, and vomiting. He recovered by morning, but he told his son he had thought he was going to die. Two weeks later, still unaware he had contracted the meat allergy, he ate a hamburger at a barbecue. He started feeling ill after 7 PM, and his son found him collapsed in the bathroom a short time later. 2
An autopsy report was inconclusive, with the cause reported as “sudden unexplained death.” The man’s wife, however, remained unsatisfied. She asked a physician to review the autopsy report; the physician contacted Platts-Mills’ team to see whether α-gal could have played a role. Platts-Mills obtained samples of the man’s blood that had been collected post mortem and found that he had been sensitized to α-gal. Further, the blood indicated the man had an extreme reaction, in line with what is seen in fatal anaphylaxis. When asked about his history of tick bites, the man’s wife said he had none this past year but had 12 or 13 chigger bites around his ankles this summer. 1,2
Platts-Mills and his colleagues suspect that several factors may have contributed to the severity of the man’s reaction, including having a beer with his burger, exposure to ragweed pollen, and having exercised that afternoon. Platts-Mills noted that the man’s family reported that he ate red meat very sparingly.
In the wake of the man’s death, Platts-Mills is urging clinicians to be on the lookout for people who have developed the allergy or are at risk of exposure. He noted that the deer population is exploding in many states, and these animals are prime breeding grounds for the Lone star tick that spreads the allergy. 1,2
“It is important that both doctors and patients who live in an area of the country where Lone star ticks are common should be aware of the risk of sensitization,” Platts-Mills said. “More specifically, if they have unexpected episodes of severe abdominal pain occurring several hours after eating mammalian meat, they should be investigated for possible sensitization to the oligosaccharide α-gal.”1
