|Videos|July 7, 2017

How Can Photodynamic Therapy Challenge Microbial Resistance of Localized Infections?

Caetano Sabino, BSc, explains how photodynamic therapy can be used to challenge microbial resistance of localized infections.

Caetano P. Sabino, BSc, PhD Student, Clinical Analysis, School of Pharmaceutical Sciences, University of Sao Paulo, explains how photodynamic therapy can be used to challenge microbial resistance of localized infections.

Interview Transcript (slightly modified for readability)

“It’s really questionable whether any resistance can be developed against photodynamic therapy; as long as we are not selecting those drug-resistant bugs in the wounds anymore through chemotherapy, we are just killing them all in the same pattern. We are just living behind the drug-resistant selection and spread, and if we could also manage the dissemination of drug-resistant genes through plasmids, we can end up with dissemination of cross-interaction in between bacteria [and] the spread of drug-resistant genes. We are just blocking the thing in the beginning.”


Related to this article

The Prospective Emergence of XDR Shigella Beyond High-Risk Groups
Los Angeles has been experiencing this challenging bacteria in recent years with the potential of it becoming carbapenem-resistant in the future. Shaun Yang, PhD, D(ABMM), FIDSA, MLS(ASCP), provides commentary about his team's work in this area and the role of genomic sequencing to uncover this troublesome pathogen.
Cefiderocol Continues to Show Activity Against Resistant Gram-Negative Infections
Shionogi data presented at IDWeek 2026 demonstrated a 76.7% clinical response with cefiderocol in carbapenem-resistant respiratory infections and high in vitro activity against resistant P aeruginosa VAP isolates. Christine Slover, PharmD, vice president, Infectious Diseases US Medical Affairs, Shionogi, offers insights on the data as well as clinical considerations for providers when weighing the antibiotic for patients.
FAQ: XDR Shigella
Here is some important information around this pathogen and the intestinal infection.