Jean van Wyk, MBChB, MFPM, discussed the 5-year OPERA data from IDWeek 2026 as well as the anticipated CROWN study results.
|Videos|February 4, 2020
Lessons From An HCV Vaccine Trial
Author(s)Contagion® Editorial Staff
Andrea L. Cox, MD, PhD, discusses the implications of discovering that an experimental vaccine was not effective at preventing chronic hepatitis C virus.
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Segment Description: Andrea L. Cox, MD, PhD, Professor of Medicine at Johns Hopkins University, discusses the implications of discovering that an experimental vaccine was not effective at preventing chronic hepatitis C virus.
Interview Transcript (modified slightly for readability):
Cox: Based on these findings, which again represent the first attempt to test a vaccine in people who are at risk for hepatitis C virus infection, we will need to do more to create an effective vaccine. One of the other potential issues in the generation of a hepatitis C virus vaccine is the extraordinary diversity of the virus.
It's well known that HIV is a very diverse virus globally, but HIV is about an order of magnitude less diverse than hepatitis C. Many of the challenges we see in an HIV vaccine are also present in the development of a hepatitis C vaccine.
One of the things we'd like to investigate with this vaccine is whether the problem was a lack of cross reactivity between the vaccine induced T-cell responses and the infecting viral strains. Which is something that we can determine. We can ideally use the results of this trial to impart additional information that will allow us to design a more effective vaccine going forward, and we hope to do that in the near future.
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Cefiderocol MICs fell against Pseudomonas aeruginosa and Klebsiella pneumoniae, and the drug showed marked synergy with LL-37 against resistant Acinetobacter baumannii. Jacinda Abdul-Mutakabbir, PharmD, MPH, AAHIVP, discusses her team's findings around this therapy and these pathogens.
Shionogi data presented at IDWeek 2026 demonstrated a 76.7% clinical response with cefiderocol in carbapenem-resistant respiratory infections and high in vitro activity against resistant P aeruginosa VAP isolates. Christine Slover, PharmD, vice president, Infectious Diseases US Medical Affairs, Shionogi, offers insights on the data as well as clinical considerations for providers when weighing the antibiotic for patients.
Karen B. Jacobson, MD, MPH, of Kaiser Permanente Northern California, presented data at IDWeek 2026 showing 58.2% of children younger than five years exposed to active hepatitis B in the home were exposed by someone other than their birth mother, a risk maternal screening alone would miss under the CDC’s revised birth dose recommendation.
Dr. Reddy’s generic twice-yearly lenacapavir received FDA tentative approval for HIV PrEP. It is expected to cost $40 a year in 120 low- and middle-income countries (LMICs), with first supplies due by the end of 2026.
David Altarac, MD, discusses 2025 SENTRY data, ESBL considerations in empiric therapy, and where ceftobiprole fits alongside ceftaroline in S aureus bacteremia.
Labcorp data presented at IDWeek 2026 show measles PCR testing nearly quadrupled and positivity rose sharply from April 2025 through March 2026, as clinicians shift toward guideline-recommended molecular testing amid ongoing US outbreaks.
In this first IDWeek 2026 roundup, oral olorofim matched AmBisome in invasive aspergillosis, aztreonam-avibactam held activity as MBL-producing CRE rose, pritelivir cut hospitalizations in refractory HSV, and zelicapavir shortened RSV symptoms in high-risk adults.
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