The Peggy Lillis Foundation (PLF) for C diff Education & Advocacy has announced the full slate of activities for National Clostridioides difficile (C diff) Awareness Month, observed each November, alongside the continuation of its flagship “See C diff” campaign. Now in its seventh year, the initiative aims to draw national attention to —America’s most common healthcare-associated infection and one that remains underrecognized despite its severe health and emotional impacts. This year’s campaign will focus on the substantial mortality associated with C diff and the long-term toll the infection takes on survivors and their families.
“C diff is far more than diarrhea—it’s a systemic infection that can lead to sepsis and death,” Christian John Lillis, PLF Co-Founder and CEO,said in a statement. He noted that roughly 30,000 Americans die from C diff infections each year—surpassing annual HIV/AIDS deaths. Throughout 2025, the organization advanced its mission through national advocacy, including its 10th annual C diff Summit and Lobby Day in Washington, DC, and by commissioning its first nationwide survey, C diff Awareness in America, which revealed a 6% increase in public awareness over four years.
What You Need to Know
The PLF's “See C diff” campaign highlights the high mortality and long-term personal impact of C diff infections, which kill 30,000 Americans each year.
PLF is expanding national awareness through advocacy, research, and education, including its new national survey showing rising public understanding of C diff.
A monthlong lineup of events—including a social media challenge, a home-cleaning safety webinar, and a major scientific symposium—aims to equip patients, caregivers, and healthcare professionals with vital knowledge and tools.
Throughout November, PLF will feature stories honoring those lost to C. diff and testimonials from families and clinicians who have witnessed the disease’s far-reaching impact. The campaign will educate the public on transmission, risk factors, symptoms, emotional burdens, and available treatments. From November 10–16, PLF will host a 7-day C diff Awareness Social Media Challenge, encouraging participants to share themed posts that promote prevention and support those affected.
On November 12, PLF will offer a webinar led by Cathy Egan, PhD, professor, Conestoga College, providing evidence-based guidance on safe home-cleaning practices during and after a C diff infection.
The organization will conclude the month with its second annual Scientific Symposium on November 21—a full-day virtual event featuring experts discussing the latest developments in C diff treatment, epidemiology, and prevention.
Reference
PEGGY LILLIS FOUNDATION ANNOUNCES “SEE C. DIFF” CAMPAIGN, EVENTS DURING NATIONAL C.DIFF AWARENESS MONTH. PLF press statement. November 3, 2025. Accessed November 3, 2025.
