J. Drew Zimmer, PharmD, BCPS *

Eravacycline is an antibiotic that has been touted for possible treatment of difficult-to-treat resistant (DTR) Gram-negative infections. But can it tackle carbapenem-resistant Acinetobacter baumannii (CRAB) infections?

Staphylococcus aureus is a major cause of both health care-acquired and community-acquired infections ranging from skin and soft tissue infections to more invasive infections like bacteremia

This In the Literature piece features a case vignette on the de-escalation of antibiotics for culture-negative pneumonia.

Evidence demonstrates that antimicrobial therapy with an anti-staphylococcal β-lactam antibiotic is the gold standard for treatment of SAB caused by MSSA, but confusion about which agent—particularly cefazolin versus an anti-staphylococcal penicillin—is preferred remains an unanswered question

Numerous studies need to be performed to ensure adequate antimicrobial dosing, partic­ularly in the setting of renal impairment and critical illness.

Are there advantageous effects to use of adjunctive IVIG in the treatment of STSS with clindamycin?