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Penicillin-Binding Proteins Reconsidered: A Clinician's Guide from Targets to Dynamic Cell-Wall Control

PBPs are more than static β lactam targets. Host conditions rewire PBP activity and peptidoglycan architecture, shaping tolerance, resistance, and how we design salvage regimens.

Invasive Fungal Disease in Transplantation: Prevention in a Shifting Landscape

Invasive fungal diseases remain a major cause of morbidity and mortality in patients undergoing transplant, with shifting epidemiology, emerging resistance, and geographic variation underscoring the urgent need for improved surveillance, prevention strategies, and antifungal stewardship.

Infectious Diseases Provider Role in Extracorporeal Membrane Oxygenation Infections

There has been an emergence of extracorporeal membrane oxygenation-associated infections. Here is a review of how to define them and clinical management of this heterogeneous syndrome.

The Aminoglyco-Side Hustle: What’s Now and Next in Gram-Negative Infections

In the midst of many changes surrounding aminoglycosides over the past several years, clinicians may be left wondering if these agents still have a role in modern clinical practice. This article summarizes changes impacting aminoglycosides, discusses where these agents may still have a role in the context of gram-negative infections, and explores future areas of study.

HIV's Golden Age: Responding to the Needs of an Aging Population

As the cohort of people living with HIV in the US ages, HIV care programs must rapidly adapt to the changing needs of older adults with HIV.

Antibiotics Deconstructed: IV Fosfomycin

The FDA recently approved intravenous fosfomycin (Contepo), which is a new option for adults with complicated urinary tract infections, including those caused by resistant Gram-negative pathogens. Here is an overview of the therapeutic including its mechanism of action, data, availability, and prospective costs.

US Flies Back American Passengers from Cruise Ship Affected by Hantavirus Exposure

Federal agencies have airlifted 17 American citizens from the MV Hondius to Nebraska for evaluation and care following exposure to the Andes variant of hantavirus. One passenger currently has mild symptoms and another passenger tested mildly PCR positive for the Andes virus.

2024 S aureus and MRSA Trials: Key Takeaways

Jeffrey Freiberg, MD, PhD review of the SABATO trial on oral antibiotics for S aureus bacteremia and a comparison of mupirocin and iodine treatments for MRSA decolonization.

Defining the Characteristics of Breakthrough Invasive Fungal Infections in Hematologic Disorders

This systematic review focuses on breakthrough invasive fungal infections (bIFIs) in patients with high-risk hematological cancers, like acute leukemia, or those who have undergone stem cell transplants. Despite prophylactic antifungal treatments (usually with voriconazole or posaconazole), bIFIs remain challenging due to their complexity and high mortality rates.

Rifaquizinone: A Novel Rifamycin-Quinolone Hybrid Antibiotic

Rifaquizinone is a dual-pharmacophore antibiotic combining rifamycin and a fluoroquinolone-like compound, showing strong bactericidal activity against resistant Staphylococcus aureus strains and biofilms, with promising results for treating prosthetic joint infections (PJI) but limited oral bioavailability.

Biopreparedness Remains Vital Despite a De-Emphasis in Public Health Policy

Despite the federal government’s recent stance on pandemic planning, author Kevin Hazzard reminds us of the importance of public health work in this area.

Updates in the Treatment of Mycobacterium Tuberculosis

The latest Bench to Bedside column reviews new guidance on the treatment of drug-susceptible and drug-resistance Mycobacterium tuberculosis infections.

New Antifungal Drug Olorofim Shows Efficacy in Treating Resistant Fungal Infections

John Rex, MD, FACP, discusses the promise, precision, and challenges of this first-in-class antifungal following phase 2b trial results.

On the Frontier of Treatment-Emergent Resistance in Stenotrophomonas maltophilia

Stenotrophomonas maltophilia is an opportunistic, multidrug-resistant pathogen that poses significant treatment challenges due to its complex resistance mechanisms, limited therapeutic options, and high mortality rates among vulnerable patients.

Further Babesiosis Biology, Pathogenicity Research Underway at Yale

Pandemic Preparedness: How Immunomics Technology is Leading the Way

The COVID-19 pandemic underscored the urgent need for global pandemic preparedness. The World Health Organization (WHO) is leading efforts to establish a global treaty to address future pandemics, with findings expected in 2025. Central to this preparedness is immunomics, a field leveraging advanced genomics technologies to study the immune system at unprecedented levels of detail.

Wiki-What? Navigating WikiGuidelines and Leveraging Their Advantages

WikiGuidelines produces novel clinical practice guidelines developed with pragmatic, applicable methodology, including a diverse author group.

Addressing Neonatal CNS Infections: Case Report of Ceftaroline Therapy in Preterm Infant With Ventriculosubgaleal Shunt

Here is a novel use of ceftaroline to treat methicillin-resistant Staphylococcus epidermidis ventriculitis in a preterm infant with a ventriculosubgaleal shunt.

From Allies to Adversaries: Antibiotics and Their Influence on Gut Microbiome

Systemic antibiotic therapy often leads to significant long-term disruptions to the gut microbiome. In addition to antibiotic stewardship, use of prebiotic fiber, fermented foods, and probiotics is a recommended strategy to minimize microbiome disruption and reestablish a healthy, diverse gut microbial population.

Antimicrobial Stewardship in the Era of Multidrug-Resistant Infections

Here are some strategies to consider for optimal utilization.

Considering Alternatives to Vancomycin for MRSA

Rachel Britt, PharmD, BCIDP, provides insights on an evolving understanding of the long-time antibiotic’s limitations for these infections and provides guidance on other agents and the role of diagnostics in finding the best agents for patients.

Infectious Diseases Provider Role in Extracorporeal Membrane Oxygenation Infections

There has been an emergence of extracorporeal membrane oxygenation-associated infections. Here is a review of how to define them and clinical management of this heterogeneous syndrome.

A Therapeutic Challenge: Quadruple-Valve Endocarditis Resulting From Injection Drug Use

Here is a case study of a patient with injection drug use, a patent foramen ovale, and recurrent MRSA bacteremia who developed rare, fatal quadruple-valve infective endocarditis involving all 4 heart valves, highlighting the high mortality risk and importance of early recognition, surgical consultation, and substance use treatment.

Destruction From Within, Resistance From Without

A series of politically driven actions in 2025—including defunding mRNA research, dismantling vaccine advisory bodies, and restricting CDC recommendations—has undermined US vaccine access and pandemic preparedness, but professional societies and some states are stepping in to preserve evidence-based public health.

Summarizing SGLT-2 Inhibitor Usage in People With Diabetes and HIV

In persons living with HIV and diabetes, the management of diabetes is lagging behind the evidence. Despite SGLT-2 inhibitors demonstrating robust clinical data in the general population, they are grossly underused in persons with HIV and diabetes.

Understanding the Current ACIP

The Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices (ACIP) was supposed to convene this week to discuss COVID-19 vaccines. However, a district court’s decision to block recent vaccine policy changes has delayed the committee's meeting amid ongoing controversy over immunization guidance and rising public health concerns such as measles outbreaks. Here is some commentary on the inner workings of the current ACIP.

What's New in 2025: From the CLSI Subcommittee on Antimicrobial Susceptibility Testing

The subcommittee approved the removal of doxycycline and tetracycline breakpoints, revised aminoglycoside breakpoints for Acinetobacter spp, and added aztreonam-avibactam breakpoints for Enterobacterales.

Intravenous Antimicrobials: Is It Time to Push?

Intravenous (IV) push is an attractive option to administer antimicrobial therapy to patients in an efficient and effective manner in a variety of clinical settings. While many advantages to IV push administration exist, clinicians should be mindful of available literature regarding safety profiles, pharmacokinetic/pharmacodynamic characteristics, and clinical data for IV push antimicrobial administration prior to utilizing it in specific patient populations.

Do You Have a Minute? Asking Infectious Diseases Clinicians to Provide Uncompensated Services

ID clinicians must be paid for time spent conducting unbillable work for OPAT services.

Local Dengue Spread in Los Angeles County Led to 14 Cases in 2024

A study assessing the local transmission found it caused 14 confirmed cases in 2024 and exposed diagnostic delays in patients without travel history.