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Bioaccumulation of Drugs by Human Gut Bacteria Can Affect Drug AvailabilityA new study demonstrated that gut organisms can alter drug availability by biotransformation on a significantly broader scale than previously expected.
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Best Practices for Getting Young Clinicians into ResearchThis time of year means new trainees will begin their careers and are excited to take on research projects. However, they may have limited to no experience in this area. Here is an opportunity to give them structure and guidance when committing to longitudinal trainee research.
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Gender-Affirming Care in Persons Living With HIVGender-affirming hormone therapy (GAHT) therapy consists of administration of exogenous hormones and suppression of endogenous hormone production, with the goal of obtaining characteristics more congruent with an individual’s gender identity. Here is a review of these therapies and consideration for PrEP and the risks associated with HIV in this diverse population.
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Antibiotic Heteroresistance: What Is It and How Does It Impact Patients?Low-frequency resistant cells in bacterial isolates are challenging to detect and may contribute to unexplained treatment failure.
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Optimizing Management of Complicated UTIsAn expert in infectious diseases reviews best practices for improving personalized medicine when treating complicated urinary tract infections and highlights the importance of antimicrobial stewardship.
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Mixed Fungal Brain AbscessClinicians review a patient case including diagnosis, treatment, and follow-up.
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Key Takeaways on FMTs in the Treatment of CDIExperts provide practice pearls for educating patients on and using FMTs for the management of CDI.
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The Future and Resources in HCV CareExpert hepatologists discuss future developments in HCV that they are excited about and provide resources for new providers to get started on delivering HCV care.
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In the Aftermath: Post-Hurricane InfectionsHurricane season is accompanied by an uptick in infectious diseases associated with environmental and water exposures.
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Influenza Virus Is Primed for Continual Emergence and Pandemic PotentialThe broad host range and natural reassortment of the influenza virus has played an instrumental role in previous pandemics, and the virus is poised for future large-scale outbreaks.
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Climate Change Effects on Vector-Borne Disease: The Case of LymeWith evolving weather patterns, the natural habitat of ticks is expanding, and more people are becoming susceptible to them.
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Biden Administration Unveils HCV Initiative: A Significant Step Towards Public HealthThe federal government is working to provide greater access to testing and treatment.
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Disseminated Gonococcal Infection Complicated by Suspected Osteomyelitis of Humeral HeadGonococcal septic polyarthritis is an uncommon manifestation of N gonorrhoeae infection, but has increased by about 40% in recent years.
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Key Takeaways on FMTs in the Treatment of CDIExperts provide practice pearls for educating patients on and using FMTs for the management of CDI.
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Long-Acting Lipoglycopeptides for the Treatment of Severe InfectionsLong-acting lipoglycopeptides (LGPs) like dalbavancin, oritavancin, and telavancin were developed with extended half-lives, initially targeting acute bacterial skin and skin structure infections (ABSSSIs). However, recent studies have explored their potential in treating other infections, including infective endocarditis (IE), bone and joint infections (BJIs), and bloodstream infections (BSIs), offering an alternative to standard care and outpatient antimicrobial therapy.
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“Triple Therapy” Facing Triple ThreatClinicians provide an overview of intraamniotic infections and offer treatment strategies for these challenging infections.
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Outpatient Antimicrobial Stewardship: The Keys to Developing a Successful ProgramThis form of stewardship can reduce unnecessary antibiotic prescribing, reduce costs, and optimize patient outcomes.
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The Impact of Widespread RSV Vaccination and Quantifying ResultsIn the fourth and final episode, the clinicians speak of the need for greater uptake of the RSV vaccines, overcoming an "RSV identity crisis," and the potential ancillary benefit of reducing bacterial infections.
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COVID-19 Booster Shots and the FutureKey opinion leaders provide some advice for the public regarding COVID-19 booster shots and look to the future of the pandemic.
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COVID-19 Convalescent Plasma: What Is Its Role in Therapy?The key is using the right dose on the right patient at the right time.
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And Then There Was One: HCV Elimination in the Coinfected PopulationThe evolution of treatment for hepatitis C virus during the past 15 years has been astounding, and we now are able to talk about how HCV could be eliminated.
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Restoring Hope by Restoring Gut Flora: Rebyota and the Future of Combating Recurrent CDIAlthough fecal microbiota, live-jslm (Rebyota; RBX2660) is the first fecal microbiota product approved by the FDA, there are other microbiota-based agents in the pipeline.
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The Roles of Misinformation, Disinformation, and Confirmation Bias in Public Health DiscourseKatrine Wallace, PhD, and Eric John Burnett, MD, discuss the distinctions between them and strategies to understand better the information people are consuming.
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COVID-19 Booster Shots and the FutureKey opinion leaders provide some advice for the public regarding COVID-19 booster shots and look to the future of the pandemic.
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Final Diagnosis: Pott Puffy Tumor With Subdural EmpyemaA rare case of Pott puffy tumor occurs in an atypical patient with no risk factors, likely due to untreated sinus infection.
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Our Price for Not Aiming Higher: Long COVID Is Here to StayGuest author Seth Lederman, MD, calls Long COVID "one of the most pressing global health threats I have seen since fighting HIV/AIDS."
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The Future of Influenza Vaccination: Insights from FluGen’s M2SR Vaccine StudyPaul Radspinner, MBA, president and CEO of FluGen, addresses the safety profile, noting the low adverse event rates highlighting the safety and tolerability of the H3N2 M2SR influenza vaccine.
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Continuous Disinfection Technology in Combating Healthcare-Associated InfectionsIn part 2 of this interview with Deborah Birx, MD, she highlights that ActivePure Technology provides a continuous decontamination solution that operates independently of manual intervention to reduce HAIs.
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SARS-CoV-2 Vaccines Show No Increased Risk for New-Onset SeizuresRegarding new-onset seizures in the general population, there was not a statistically significant variance in the risk of experiencing seizures between those who received the vaccine and those who got a placebo.
