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Penicillin-Binding Proteins Reconsidered: A Clinician's Guide from Targets to Dynamic Cell-Wall Control

PBPs are more than static β lactam targets. Host conditions rewire PBP activity and peptidoglycan architecture, shaping tolerance, resistance, and how we design salvage regimens.

China Reports Over 7,000 Chikungunya Cases in Guangdong Province Amid Aggressive Containment Efforts

China's largest recorded chikungunya outbreak prompts strict mosquito control and mandatory hospitalization in Foshan.

The Increasing Burden of Multidrug-Resistant Neisseria Gonorrhoeae: Zoliflodacin to the Rescue?

Zoliflodacin has exhibited low cross-resistance with FQ-resistant and ceftriaxone- and azithromycinresistant in strains of N gonorrhoeae around the world. Here is a review of this recently approved antibiotic.

What's New In 2024: From the CLSI Subcommittee on Antimicrobial Susceptibility Testing

The Clinical and Laboratory Standards Institute (CLSI) Subcommittee on Antimicrobial Susceptibility Testing had its series of meetings to update breakpoints for a variety of classes of antimicrobials.

Vegetable Oil-Based Diet Supports Liver Health in Chronic Hepatitis B Patients

Unsaturated fats in vegetable oils help reduce inflammation and modulate organ metabolism, leading to decreased ALT, AST, and TBIL levels.

Review of Cefepime and Zidebactam: A Novel Antibiotic Approved to Treat Complicated Urinary Tract Infections

In May 2026, the FDA approved a combination product of cefepime and zidebactam for the treatment of complicated urinary tract infections, including pyelonephritis, providing a new treatment option for multidrug-resistant gram-negative organisms. Here is a clinical overview of the newly approved antibiotic.

Penicillin-Binding Proteins Reconsidered: A Clinician's Guide from Targets to Dynamic Cell-Wall Control

PBPs are more than static β lactam targets. Host conditions rewire PBP activity and peptidoglycan architecture, shaping tolerance, resistance, and how we design salvage regimens.

Invasive Fungal Disease in Transplantation: Prevention in a Shifting Landscape

Invasive fungal diseases remain a major cause of morbidity and mortality in patients undergoing transplant, with shifting epidemiology, emerging resistance, and geographic variation underscoring the urgent need for improved surveillance, prevention strategies, and antifungal stewardship.

Infectious Diseases Provider Role in Extracorporeal Membrane Oxygenation Infections

There has been an emergence of extracorporeal membrane oxygenation-associated infections. Here is a review of how to define them and clinical management of this heterogeneous syndrome.

The Aminoglyco-Side Hustle: What’s Now and Next in Gram-Negative Infections

In the midst of many changes surrounding aminoglycosides over the past several years, clinicians may be left wondering if these agents still have a role in modern clinical practice. This article summarizes changes impacting aminoglycosides, discusses where these agents may still have a role in the context of gram-negative infections, and explores future areas of study.

HIV's Golden Age: Responding to the Needs of an Aging Population

As the cohort of people living with HIV in the US ages, HIV care programs must rapidly adapt to the changing needs of older adults with HIV.

Antibiotics Deconstructed: IV Fosfomycin

The FDA recently approved intravenous fosfomycin (Contepo), which is a new option for adults with complicated urinary tract infections, including those caused by resistant Gram-negative pathogens. Here is an overview of the therapeutic including its mechanism of action, data, availability, and prospective costs.

Susceptible…but Not Responding: When Lab Results Don’t Match the Patient

Standard susceptibility testing is performed under controlled conditions that often fail to reflect real-world infections, leading to potential misinterpretation of antibiotic activity in patients with bacteremia.

2024 S aureus and MRSA Trials: Key Takeaways

Jeffrey Freiberg, MD, PhD review of the SABATO trial on oral antibiotics for S aureus bacteremia and a comparison of mupirocin and iodine treatments for MRSA decolonization.

Two Outbreaks Reveal a Dangerous Double Standard in Global Health

The stark contrast between the rapid global response to the Andes virus exposure on a cruise ship and the slower, under-resourced response to the Bundibugyo Ebola outbreak in Central Africa highlights how global health inequities—and the disproportionate burden placed on women caregivers—shape infectious disease outcomes as much as the pathogens themselves.

Defining the Characteristics of Breakthrough Invasive Fungal Infections in Hematologic Disorders

This systematic review focuses on breakthrough invasive fungal infections (bIFIs) in patients with high-risk hematological cancers, like acute leukemia, or those who have undergone stem cell transplants. Despite prophylactic antifungal treatments (usually with voriconazole or posaconazole), bIFIs remain challenging due to their complexity and high mortality rates.

Rifaquizinone: A Novel Rifamycin-Quinolone Hybrid Antibiotic

Rifaquizinone is a dual-pharmacophore antibiotic combining rifamycin and a fluoroquinolone-like compound, showing strong bactericidal activity against resistant Staphylococcus aureus strains and biofilms, with promising results for treating prosthetic joint infections (PJI) but limited oral bioavailability.

Biopreparedness Remains Vital Despite a De-Emphasis in Public Health Policy

Despite the federal government’s recent stance on pandemic planning, author Kevin Hazzard reminds us of the importance of public health work in this area.

Updates in the Treatment of Mycobacterium Tuberculosis

The latest Bench to Bedside column reviews new guidance on the treatment of drug-susceptible and drug-resistance Mycobacterium tuberculosis infections.

New Antifungal Drug Olorofim Shows Efficacy in Treating Resistant Fungal Infections

John Rex, MD, FACP, discusses the promise, precision, and challenges of this first-in-class antifungal following phase 2b trial results.

On the Frontier of Treatment-Emergent Resistance in Stenotrophomonas maltophilia

Stenotrophomonas maltophilia is an opportunistic, multidrug-resistant pathogen that poses significant treatment challenges due to its complex resistance mechanisms, limited therapeutic options, and high mortality rates among vulnerable patients.

Further Babesiosis Biology, Pathogenicity Research Underway at Yale

Pandemic Preparedness: How Immunomics Technology is Leading the Way

The COVID-19 pandemic underscored the urgent need for global pandemic preparedness. The World Health Organization (WHO) is leading efforts to establish a global treaty to address future pandemics, with findings expected in 2025. Central to this preparedness is immunomics, a field leveraging advanced genomics technologies to study the immune system at unprecedented levels of detail.

Two Outbreaks Reveal a Dangerous Double Standard in Global Health

The stark contrast between the rapid global response to the Andes virus exposure on a cruise ship and the slower, under-resourced response to the Bundibugyo Ebola outbreak in Central Africa highlights how global health inequities—and the disproportionate burden placed on women caregivers—shape infectious disease outcomes as much as the pathogens themselves.

Wiki-What? Navigating WikiGuidelines and Leveraging Their Advantages

WikiGuidelines produces novel clinical practice guidelines developed with pragmatic, applicable methodology, including a diverse author group.

Addressing Neonatal CNS Infections: Case Report of Ceftaroline Therapy in Preterm Infant With Ventriculosubgaleal Shunt

Here is a novel use of ceftaroline to treat methicillin-resistant Staphylococcus epidermidis ventriculitis in a preterm infant with a ventriculosubgaleal shunt.

From Allies to Adversaries: Antibiotics and Their Influence on Gut Microbiome

Systemic antibiotic therapy often leads to significant long-term disruptions to the gut microbiome. In addition to antibiotic stewardship, use of prebiotic fiber, fermented foods, and probiotics is a recommended strategy to minimize microbiome disruption and reestablish a healthy, diverse gut microbial population.

Antimicrobial Stewardship in the Era of Multidrug-Resistant Infections

Here are some strategies to consider for optimal utilization.

Considering Alternatives to Vancomycin for MRSA

Rachel Britt, PharmD, BCIDP, provides insights on an evolving understanding of the long-time antibiotic’s limitations for these infections and provides guidance on other agents and the role of diagnostics in finding the best agents for patients.

Infectious Diseases Provider Role in Extracorporeal Membrane Oxygenation Infections

There has been an emergence of extracorporeal membrane oxygenation-associated infections. Here is a review of how to define them and clinical management of this heterogeneous syndrome.