Antimicrobial Stewardship

At IDWeek 2022, Erica Stohs, MD, MPH, presented surprising findings about unnecessary antibiotics in a cohort coinfected with COVID-19 and pneumonia.

There is a significant need for C difficile treatments that don’t destroy the microbiome.

Antimicrobial stewardship works, one IDWeek 2022 study found.

Shionogi shared positive clinical cure rates from their ongoing trial of Fetroja (cefiderocol) for difficult-to-treat Gram-negative infections.

Extending antimicrobial stewardship programs to transition of care and discharge may prove beneficial to reduce unnecessary antibiotic use.

Novel β-lactamase inhibitor enmetazobactam with cefepime exceeded noninferiority to piperacillin/tazobactam in complicated UTI, pyelonephritis.

Oral antibiotics after partial completion of intravenous regimen for S aureus bacteremia improves outcomes of persons who inject drugs (PWID), which is a population that often has limited access to treatment.

Gonococcal septic polyarthritis is an uncommon manifestation of N gonorrhoeae infection, but has increased by about 40% in recent years.

The limitation in the number of pediatric-specific guidelines by professional organizations, and results from large randomized clinical trials, may place an additional emphasis on literature evaluation skills for pediatric ASP pharmacists.

Recent issues surrounding the ADAPT-PO and SURE-2 trials place the spotlight on the difficulties developing oral carbapenem-based antibiotics and case their future into doubt.

Salmonella becomes more dangerous as antimicrobial resistance grows. Read about its most common manifestations.

Although there are challenges for clinical and infectious disease pharmacists when trying to apply this concept, here are some considerations and strategies to employ stewardship in this setting.

Eravacycline is an antibiotic that has been touted for possible treatment of difficult-to-treat resistant (DTR) Gram-negative infections. But can it tackle carbapenem-resistant Acinetobacter baumannii (CRAB) infections?

The study authors identified four main approaches to antimicrobial stewardship programs after questionnaire and focus group discussions with ASP leaders.

Here is a review of using this therapy in this patient population.

Although hospitalizations due to urinary tract infections have increased, there are some investigational antibiotics in clinical trials. Here is a review of some of these therapies in the pipeline.

In the latest column from the Society of Infectious Diseases Pharmacists (SIDP), here is a discussion on the use of rifampin as an adjunctive antibiotic treatment for patients with diabetic foot osteomyelitis.

When physicians were told that a case was likely viral they were less likely to prescribe antibiotics, a new study shows.

Dentists write about 25.7 million prescriptions annually, amounting to about 10% of all outpatient antibiotic prescriptions in the United States. A recent study showed that educating dentists about the risks of antibiotics—including antimicrobial resistance and Clostridioides difficile infections—led to sharp decreases in prescriptions.

Finding that the COVID-19 pandemic disrupted best antibiotic practices, the CDC announced further efforts to curb treatment-resistant infections.

With antimicrobial resistance a rising threat, the World Health Organization is working to heighten awareness of the urgent need for new therapies.

Here is a review of the literature for this class of antibiotics.

Investigators designed a quasi-experimental pre- and post-intervention analysis comparing a pre-intervention cohort receiving IV drip antibiotic infusion with a post-intervention cohort receiving IVP administration.

Working to Fight AMR is working in Washington DC to help pass policies in Congress to help alleviate this significant issue.

A robust stewardship program requires a comprehensive investment in technology and staff.

CDC attributes a 15% increase in deaths from antimicrobial-resistant infections in 2020 to impacts of COVID-19 on health and healthcare.

Most children with multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 receive improper antimicrobial treatment, according to a recent study that highlights an urgent need to improve diagnosis and treatment of the condition.

Work group from infectious disease associations proposes prioritizing 6 areas of research to improve efficacy and precision of antibiotic therapy

The largest genome sequence of S Typhi found strains of the bacteria are developing and spreading resistance to new antibiotics.

Carbapenem-resistant enterobacterales in Saudi Arabia were genotyped and the course of illness characterized to help inform treatment and prevention.