Does Earlier Remdesivir Initiation Improve COVID-19 Recovery Time?
One study, presented at the Critical Care Congress, found that initiating remdesivir (Veklury) earlier did not significantly reduce the recovery time of hospitalized COVID-19 patients.
Few Readmissions After Hospitalization for CAP Are Avoidable
An analysis of readmissions after hospitalization with community-acquired pneumonia (CAP) in France found that few readmissions were avoidable, supporting criticism that the measure may lead to unfair penalties under pay-for-performance programs.
Antimicrobial Stewardship Education Reduces Antibiotic Prescriptions in COVID-19 Patients
Antimicrobial stewardship efforts, such as education for healthcare providers, significantly decreased community-acquired pneumonia antibiotic prescriptions in COVID-19 patients.
Initiating Antibiotic for Severe Pneumonia from Gram Staining Could Reduce Broad Spectrum Agents
Selecting initial antibiotic for ventilator-associated pneumonia from Gram staining and resistance records could reduce broad spectrum agents.
Text Messages Saying Influenza Vaccine ‘Reserved for You’ May Boost Uptake
Patients scheduled for primary care appointments were more likely to get an influenza vaccine if they received a text message the night before indicating one was reserved for them, a new study shows.
Monoclonal Antibodies More Effectively Neutralize BA.2 Than BA.1
Though many monoclonal antibodies were paused after demonstrated to be insufficient against the BA.1 Omicron subvariant, they may be more effective against BA.2.
Fluvoxamine Prevents COVID-19 Hospitalizations in Outpatient Settings
A systematic review of clinical trials found a high probability that fluvoxamine prevented COVID-19 hospitalizations in outpatient settings.
COVID-19 Infection Increases Risk of Deep Vein Thrombosis, Pulmonary Embolism, Bleeding
The risks of deep vein thrombosis, pulmonary embolism, and bleeding events were increased at 3 or more months after COVID-19 infection.
Did Full FDA Approval of the Pfizer-BioNTech Vaccine Increase COVID-19 Vaccinations?
After the US Food and Drug Administration (FDA) fully authorized the Pfizer-BioNTech mRNA vaccine, series-completing second doses increased substantially. However, first vaccine doses were actually administered at lower rates after the approval.
TB Resistance to Bedaquiline When It's Not Reserved as Last Resource
Bedaquiline-resistant tuberculosis is characterized in South Africa, where it has not been reserved as last resource for drug-resistant TB.
How Rapidly Did Hospitals Adopt COVID-19 Recommended Procedures?
Notoriously slow to implement new practices, most hospitals rapidly updated their standard treatment procedures during the COVID-19 pandemic.
In Children Under 5, Omicron COVID-19 Infection Was More Likely, But Delta Was More Severe
Children under 5 became infected with the Omicron variant 6-8 times more frequently than young children who contracted Delta. However, Delta COVID-19 infections were more severe than Omicron.
Indigenous Americans Have Disproportionately High COVID-19 Mortalities
Despite lower comorbidity risk scores than Black or White COVID-19 patients, Mississippi’s Indigenous populations had significantly higher in-hospital mortality rates.
NIH Launches Trial Evaluating Second COVID-19 Booster Shots
One day after the FDA approved second booster shots for certain vulnerable populations, the National Institute of Health (NIH) announced they have begun enrolling adult US participants in a phase 2 clinical trial to evaluate a second COVID-19 booster dose.
Pfizer Vaccine Efficacy in Children and Adolescents During Delta and Omicron
2 doses of the Pfizer-BioNTech vaccine reduced Omicron hospitalizations by 68% in children 5-11 and by 40% in adolescents 12-18 years old.
Black Patients With Cancer Had Worse COVID-19 Outcomes
“Together these 2 diseases create a perfect storm”: Black people with cancer were more likely to have severe or fatal COVID-19 disease.
Study Shows Shorter TB Treatment for Kids is Noninferior; WHO Updates Guidance
The World Health Organization updated its guidelines for the treatment of nonsevere tuberculosis in children after a study showed a four-month duration was noninferior to six months.
First Study to Estimate Life Expectancy After COVID-19 Pandemic Finds 2 Years Lost
The coronavirus pandemic caused the first global recorded decline in human life expectancy.
Sotrovimab Distribution Paused in Areas Where BA.2 Is Dominant COVID-19 Variant
The Assistant Secretary for Preparedness and Response (ASPR) announced a pause in sotrovimab distribution in regions where BA.2 is the dominant COVID-19 variant, citing evidence that the monoclonal antibody therapy would not effectively neutralize the BA.2 Omicron variant.
World Tuberculosis Day 2022: Today’s State of the Infectious Disease
March 24 is World Tuberculosis Day. Here’s a brief history of the second deadliest infectious disease, and how it affects the world today.
Type 2 Diabetes Diagnosis More Likely After COVID-19 Infection
A matched cohort study found COVID-19 infection increased the risk of new type 2 diabetes diagnosis. Compared to patients with acute upper respiratory tract infections, COVID-19 patients were 28% more likely to develop diabetes.
“Most Transmissible Variant” BA.2 Expected to Overtake Original Omicron Strain
There are many unknowns about the BA.2 COVID-19 variant. It appears 50-60% more transmissible than the original Omicron variant, but health experts are mixed on whether cases will spike dramatically.
Children’s Duration of COVID-19 Immunity from Natural Infection
A Texas study found children and adolescents who previously contracted COVID-19 retained protective antibodies for 6 or more months after infection. However, natural infection plus vaccination remains the best defense against COVID-19.
With New Variants, COVID-19 Vaccination Mildly Effective in Children
In children and adolescents, the Pfizer-BioNTech vaccine was only mildly effective against symptomatic and asymptomatic COVID-19 infections. Broken down by variant, Omicron infections were more likely to occur and more likely to be asymptomatic.
New “Long Covid” Treatment Looks to Improve Patient Feeling and Function
Axcella Therapeutics chief medical officer Dr. Margaret Koziel discusses the stage 2a clinical trial for their novel long covid treatment.
New “Deltacron” COVID-19 Sub-Variant Could Be as Contagious as Measles
The new COVID-19 sub-variant, called “Deltacron” or “Stealth Omicron,” appears to be the most contagious strain yet. However, this does not necessarily mean there will be a dramatic spike in cases.
Public Health Watch: ‘Substantial Burden’ of Influenza and RSV Deaths in US Prior to COVID-19 Pandemic
Findings of JAMA Network Open analysis reveal effects of interventions designed to prevent spread.
Not Over Yet: Researchers Identify “Deltacron” Hybrid COVID-19 Variant
“Deltacron,” a COVID-19 strain with genes from both the Delta and Omicron variants, appears to have been circulating since the beginning of the year.
War on Ukraine Sparks Healthcare and Disease Crises
The war on Ukraine is expected to drive COVID-19 and other infectious diseases, meaning health organizations and neighboring countries should prepare to assist in the impending health crises.
Effects of Switching Antibiotics Mid-Treatment on Antimicrobial Resistance
Using real-time genetic surveillance, investigators found bacterial infections rapidly develop resistance to antibiotics, only to have these gene mutations disappear within a few days of switching to a different treatment.
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