January 27th 2023
The week's most-clicked COVID-19 stories included vaccine updates, new variants, and a pivotal FDA advisory committee vote.
January 24th 2023
COVID-19 patients had a significantly higher risk of cardiovascular disease and death in both the short- and long-term.
January 23rd 2023
What factors contribute to post-COVID-19 conditions (“long COVID”)? Can vaccination before or after a COVID-19 infection decrease the risk of long COVID?
January 21st 2023
Reported reasons adults had not received a bivalent COVID-19 booster dose differed across age groups.
January 20th 2023
Click on the slideshow images to read the full stories featured in this weekly infectious disease recap.
Moderna RSV Vaccine for Seniors Meets Primary Endpoints for its Phase 3 Trial
With these results, the company plans to submit their investigational vaccine, MRNA-1345, for regulatory approval in the first half of 2023.
High Mucosal Antibodies in Airways Reduce COVID-19 Reinfection by 55%
High levels of mucosal IgA antibodies in the airways were found to protect against COVID-19 reinfection for at least 8 months.
Investigators Test Potential “Universal” Vaccine Against SARS-CoV-2 Variants
Preclinical testing suggests that a newly developed SARS-CoV-2 vaccine could protect against current and future variants.
Convalescent Plasma Reduced Mortality in Immunocompromised COVID-19 Patients
As COVID-19 continues to mutate, immunocompromised persons need new, effective treatments. Convalescent plasma could be the answer.
This Week's Most-Read Infectious Disease Stories
It's Friday the 13th, but you can counteract bad luck by catching up on this week's top infectious disease news.
Males Found to be More Susceptible to Respiratory Bacterial Infections
A 2-year retrospective study looking at patients admitted to the ICU showed that the number of intubated males infected with Acinetobacter baumannii (AB) was double the number of intubated females.
FDA Approves Tdap Vaccine for Pregnant Mothers to Prevent Pertussis in Young Infants
The agency licensed the new indication for Sanofi’s Adacel (Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed [Tdap]) shot for immunization during the third trimester of pregnancy.
On the Precipice of the World's First RSV Vaccine: What's Taking so Long?
RSV cases spiked to unprecedented levels this season. Why were these infections so frequent and severe? Why has vaccine development taken so long?
Diagnostic Stewardship is a Novel Concept That Will Influence Treatment Protocols
Newer diagnostic technologies can play a role in identifying specific bacterium, decrease the time to optimal therapy, and offer the possibility of better outcomes.
This Week’s Top 5 Infectious Disease Stories
So far, these are Contagion's 5 most-read stories of 2023.
FDA Accepts BLA for Nirsevimab for RSV Prevention for Infants
Developed by Sanofi and AstraZeneca, the single-dose long-acting antibody was designed to help protect all infants from birth through their first respiratory syncytial virus (RSV) season.
Vaxcyte’s Pneumococcal Vaccine Receives FDA Breakthrough Therapy Designation
The 24-valent investigational pneumococcal conjugate vaccine, VAX-24, met its primary endpoints in a phase 1/2 trial.
Cyproheptadine Arm of COVID-19 Treatment Study Terminated
Due to negative results, the I-SPY COVID Trial is no longer evaluating cyproheptadine to treat critically ill COVID-19 patients.
Molnupiravir Doesn’t Decrease COVID-19 Deaths or Hospitalizations, but May Speed Recovery
Despite failing to meet primary trial endpoints, molnupiravir reduced the length of COVID-19 infection by 4.2 days in vaccinated patients.
How the COVID-19 Pandemic Changed State-Level Cigarette Sales
During the COVID-19 pandemic, cigarette sales differed from projected sales volume. One study examined these trends at the state level.
Flu and RSV and Amoxicillin? Oh My!
Editor-in-Chief Jason Gallagher discusses the surging number of cases of influenza and RSV while there is a concomitant shortage of amoxicillin suspension.
New Research Shows “Y” Men Are More Likely to Have Severe COVID-19
With these findings, the Uppsala University investigators believe loss of the Y chromosome in white blood cells can predict which patients are at high risk of severe COVID-19 disease progression.
Recent Flu Updates from the CDC
All regions are experiencing influenza-like illness levels above the baseline, the CDC said.
CDC Outlines Best Practices for Priorix for MMR Vaccination
Priorix and M-M-R II are fully interchangeable vaccines to protect against measles, mumps, and rubella, the CDC’s Advisory Committee on Immunization Practices said.
RSV Resurges as COVID Pandemic Precautions Recede
Earlier and higher rates of RSV and other respiratory illnesses following reduced COVID precautions challenge capacity of pediatric units.
Wearing Masks Didn’t Increase Face Touching Among Kids in Simulated School Study
The benefits to children of wearing face masks to prevent COVID-19 outweigh potential infectious risks from face touching, according to a study analyzing hand-to-face contact in a simulated school environment.
FDA Fast-Tracks Codagenix RSV Vaccine Candidate
The intranasal, live-attenuated vaccine CodaVax-RSV was granted FDA Fast Track designation. Clinical trials are expected to launch soon.
Pfizer Announce Positive Data on RSV Vaccine for Pregnant Mothers
Vaccine efficacy of 81.8% was observed against severe medically attended lower respiratory tract illness due to respiratory syncytial virus (RSV) in infants from birth through the first 90 days of life.
Who Doesn’t Love a Prequel? SARS Before CoV-2
Our cover story for the October 2022 print edition of Contagion details the original coronavirus.
RSV Vaccine Effective at Preventing Lower Respiratory Tract Infection in Older Adults
The investigational vaccine was effective in reducing both lower respiratory tract and all respiratory tract infections.
SNG001 Fails Primary Endpoints, But May Alleviate Long COVID Symptoms
Despite no significant reduction in time to discharge or recovery, inhalable SNG001 may lessen common symptoms of “long COVID.”
GSK Shares Promising Results From Respiratory Syncytial Virus Vaccine Trial
Ahead of the IDWeek 2022 conference, GSK shared data from their phase 3 RSV vaccine trial.
Historical Perspective: Lessons from SARS-CoV-1
Before the emergence of COVID-19, this precursor virus was a global concern.
The Top Infectious Disease Stories This Week
Articles covering respiratory infections were our most-clicked this week.
Increase in Enteroviruses Seen with Decreases in COVID-19 Precautions
The Centers for Disease Control and Prevention (CDC) reports the rise in pediatric acute respiratory illnesses especially as there is a decrease in hygiene measures that were previously employed during the pandemic.
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