Get the content you want anytime you want.

Obesity & Heart Failure Increase Odds of Treatment Failure in SSTI Patients

Among these patients, 182 (62%) received treatment for cellulitis, 67 (23%) received treatment for abscesses, and 44 (15%) received treatment for mixed cellulitis and abscesses. Sixteen percent of the patients had a body mass index (BMI) greater than 40 kg/m2.

According to Dr Mergenhagen, patients with obesity and heart failure were at greater risk for failure of oral antibiotics for SSTIs.
Patients who failed oral antibiotic therapy had a greater mean BMI than those who experienced successful treatment (34.2 kg/m2 vs31.32 kg/m2; P = 0.0098); they also had an increased prevalence of heart failure (15.9% vs 7.1%; P = 0.027).
Each 10-kg/m2 unit increase in BMI was associated with a 1.62-fold odds of antibiotic failure. In addition, heart failure increased the risk by 2.6-fold, the authors say.
“Further studies are needed to discover possible solutions to avoid subsequent hospital admissions,” stressed Dr Mergenhagen. Some possible solutions might include increased doses of oral antibiotics, use of intravenous antibiotic therapy, or closer follow up with health care professionals, she added. 

Dr Mergenhagen and colleagues are now completing the inpatient counterpart to this outpatient study, in order to identify factors for failure in both the inpatient and outpatient settings.
“With an expanded inpatient population, we hope to identify solutions to combat high failure rates in this population,” she concluded.

Dr. Parry graduated from the University of Liverpool, England in 1997 and is a board-certified veterinary pathologist. After 13 years working in academia, she founded Midwest Veterinary Pathology, LLC where she now works as a private consultant. She is passionate about veterinary education and serves on the Indiana Veterinary Medical Association’s Continuing Education Committee. She regularly writes continuing education articles for veterinary organizations and journals, and has also served on the American College of Veterinary Pathologists’ Examination Committee and Education Committee.
To stay informed on the latest in infectious disease news and developments, please sign up for our weekly newsletter.

Big advances in treatment can