For livestock producers, the consequences can be severe. Cattle are among the most affected animals because routine management practices—including branding, ear tagging, castration, dehorning, or even tick bites—can create wounds attractive to egg-laying female flies.9 Sheep, goats, horses, swine, and companion animals such as dogs may also become infected. Wildlife, including deer and other mammals, can serve as hosts, complicating eradication efforts because infected wild animals can transport the parasite across large geographic areas.
Once larvae hatch, they burrow deeper into the wound while feeding in a screw-like pattern that gives the parasite its common name. The infestation enlarges rapidly, producing extensive tissue destruction, inflammation, bleeding, and a characteristic foul odor. Animals often exhibit obvious signs of distress, including restlessness, isolation from the herd, loss of appetite, and weight loss. As infestation progresses, affected animals may become weak, develop secondary bacterial infections, or die if treatment is delayed.
The economic implications extend well beyond individual animal losses. Producers may face veterinary expenses, decreased weight gain, reduced milk production, reproductive losses, and restrictions on animal movement or international trade. Historically, before eradication in the United States, screwworm cost the livestock industry hundreds of millions of dollars annually when adjusted for today's economy. These economic impacts helped drive one of the largest coordinated insect eradication programs ever undertaken.
From a wildlife perspective, screwworm represents a conservation challenge as well. Endangered species are not immune to infestation. During outbreaks, wildlife populations may experience increased mortality, and surveillance becomes considerably more difficult because affected animals are often inaccessible or discovered only after advanced disease.
Although human cases are relatively rare compared with animal infections, they are well documented. Human myiasis typically occurs when flies deposit eggs into untreated wounds or natural body openings such as the nose, ears, or eyes. Individuals living or traveling in endemic areas, agricultural workers, people with chronic wounds, or those unable to maintain adequate wound hygiene may be at greater risk.
Importantly, humans do not "catch" screwworm from another infected person or animal through ordinary contact.10 Each case develops when an adult female fly deposits eggs directly onto susceptible tissue. Nevertheless, human infections require prompt medical attention because the larvae continue feeding on living tissue until removed.
The broader lesson is that screwworm exemplifies the interconnected nature of One Health, recognizing that human health, animal health, and environmental health are closely linked. An outbreak affecting livestock can influence wildlife conservation, food production, economics, and ultimately public health infrastructure.
Diagnosis and Treatment: Early Recognition Saves Lives
Prompt diagnosis is critical because the severity of tissue damage increases rapidly as larvae mature.11 Fortunately, experienced veterinarians and physicians can often recognize screwworm based on characteristic clinical findings, although laboratory confirmation remains important for surveillance and control efforts.
Typical signs include:
- A wound that unexpectedly enlarges rather than heals
- Bloody or serous discharge
- Foul-smelling tissue
- Visible movement within the wound
- Clusters of cream-colored larvae
- Persistent irritation despite routine treatment
Animals may repeatedly lick or bite the affected area, while humans often report pain, itching, or the sensation of movement within the wound.
Laboratory identification generally involves collecting larvae and submitting them to specialized diagnostic laboratories, where entomologists examine their distinctive morphological characteristics. Increasingly, molecular diagnostic techniques such as polymerase chain reaction (PCR) and DNA sequencing provide rapid and highly accurate species identification, allowing authorities to distinguish New World screwworm from other fly species that produce myiasis.12
Treatment focuses on two primary goals: eliminating the larvae and managing the wound.11
Mechanical removal of all larvae is essential. Depending on the location and severity of infestation, veterinarians or physicians may manually extract larvae while carefully cleaning the affected tissue. Failure to remove every larva may allow continued tissue destruction.
Following removal, thorough wound cleansing and debridement help eliminate damaged tissue and reduce bacterial contamination. Secondary bacterial infections frequently require antimicrobial therapy based on clinical evaluation. Pain management and supportive care are also important, particularly for severely affected animals.
In veterinary medicine, approved antiparasitic agents and topical insecticides may assist treatment and help prevent reinfestation. Livestock producers should always follow veterinary guidance and applicable regulatory recommendations when selecting treatments.
For human patients, management depends on the location and extent of infestation but similarly centers on complete larval removal, wound care, and treatment of any secondary infection. Early medical evaluations significantly improve outcomes.
Perhaps the most important principle is simple: suspected screwworm cases should be reported immediately to appropriate animal health authorities. Rapid reporting enables surveillance teams to investigate, confirm diagnoses, and implement containment measures before additional flies emerge and spread the infestation.13
Prevention and the Future: Science, Surveillance, and One Health
The history of screwworm demonstrates that prevention is far more effective than treatment. Because each female fly mates only once during her lifetime, disrupting reproduction has proven to be one of the most successful biological control strategies ever developed.14
The Sterile Insect Technique (SIT) remains the cornerstone of eradication efforts. Millions of laboratory-reared male flies are sterilized through carefully controlled irradiation and then released into affected areas. These sterile males compete successfully with wild males for mates. When females mate with sterile males, they produce no viable offspring, gradually causing the local population to collapse.
Unlike widespread pesticide application, SIT is highly species-specific and environmentally responsible. It targets the reproductive biology of screwworms without broadly affecting beneficial insects or ecosystems. The success of this program has made it a model for integrated pest management worldwide.
Surveillance also plays a central role. Veterinary authorities monitor livestock, wildlife, and animal movement while maintaining diagnostic capacity to identify suspect cases quickly. Producers are encouraged to inspect animals regularly, particularly following procedures that create wounds or during seasons favorable for fly activity.
Practical preventive measures include:
- Prompt cleaning and protection of wounds
- Careful monitoring of newborn animals
- Appropriate fly control programs
- Timely veterinary evaluation of non-healing wounds
- Reporting suspicious infestations to animal health officials
- Following movement restrictions during outbreaks
For travelers and healthcare providers, awareness is equally important. Individuals returning from endemic regions who develop unusual wound infestations should seek medical evaluation, and clinicians should consider myiasis in the appropriate clinical context.
What You Need to Know
The New World screwworm was eliminated from the U.S. in 1966 through the Sterile Insect Technique (SIT), but outbreaks that began in Central America in 2023 have spread northward, with new livestock detections confirmed in Texas in 2026.
Unlike most fly larvae that feed on dead tissue, screwworm larvae consume living tissue, causing severe wounds, animal suffering, and potentially fatal infestations if left untreated.
The parasite's historic eradication demonstrated the effectiveness of SIT and international surveillance programs, but the recent resurgence highlights the need for continued monitoring and rapid containment to prevent widespread re-establishment.
The recent re-emergence of New World screwworm near the United States serves as a reminder that infectious and parasitic diseases do not recognize political boundaries. Climate conditions, animal movement, wildlife migration, and international commerce all influence disease ecology. Continuous investment in surveillance, scientific research, international collaboration, and public education remains essential.
Final Thoughts: An Old Threat That Demands Modern Vigilance
The New World screwworm is both an extraordinary biological organism and a significant veterinary and public health challenge. Although often described simply as a "flesh-eating parasite," its true importance lies in its ability to exploit even minor wounds, causing devastating disease in livestock, wildlife, and occasionally humans.
The United States once demonstrated that science, innovation, and international cooperation could successfully eliminate this parasite through one of the most remarkable eradication campaigns in history. The recent detections underscore that such achievements require ongoing vigilance rather than complacency.15
From producers inspecting cattle to veterinarians diagnosing unusual wounds, physicians recognizing rare cases of myiasis, entomologists monitoring fly populations, and public health officials coordinating surveillance, every component contributes to protecting animal agriculture and human health.
Ultimately, the story of screwworm is not merely about a parasite. It is a compelling example of the One Health concept in action—illustrating how human health, animal health, environmental stewardship, and scientific innovation intersect to address emerging biological threats. Continued investment in research, surveillance, and education will be essential to ensuring that this once-eradicated pest does not regain a permanent foothold in the United States.16
References
International Atomic Energy Agency (IAEA). Sterile insect technique. https://www.iaea.org/topics/sterile-insect-techniquePublished Unknown. Accessed June 8, 2026.
Rohde R.E. Will Physicians and MLS Professionals be Prepared to Diagnose the Return of Vaccine-Preventable Diseases? “Under the Microscope” – Healthcare Hygiene Magazine. March / April, Volume 8, Number 3/4, pp 12-13. https://www.healthcarehygienemagazine.com/monthly-issues/#flipbook-df_30457/13/ Published March 20, 2026. Accessed June 8, 2026.
Palinski, R., Hicks, J., Alfred, J.T. et al. Validation of a molecular workflow for Cochliomyia hominivorax (New World screwworm) identification in field samples. Sci Rep (2026). https://doi.org/10.1038/s41598-026-54866-6 Published June 3, 2026. Accessed June 8, 2026.
American Veterinary Medical Association (AVMA). AVMA News. Officials call for veterinary vigilance as screwworms move closer to US. By R. Scott Nolen and Malinda Larkinhttps://www.avma.org/news/officials-call-veterinary-vigilance-screwworm-moves-closer-us Published September 22, 2025. Accessed June 9, 2026.
Rohde R.E. Re-emerging Diseases and the Need for Diagnostic Readiness. American Society of Microbiology, Bugs and Drugs article. https://asm.org/articles/2026/april/re-emerging-diseases-and-the-need-for-diagnostic-r Published April 24, 2026. Accessed June 8, 2026.
