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Expanded Treatment Options for Multi-Drug Resistant Infections in ChildrenIn the latest article from SIDP, here is a look at therapy options addressing this emerging clinical challenge.
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UTIs: Why Did You Have to Go and Make Things so Complicated?Although hospitalizations due to urinary tract infections have increased, there are some investigational antibiotics in clinical trials. Here is a review of some of these therapies in the pipeline.
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From Pandemic to EndemicA research agenda focusing on breakthrough infections, reinfections, severity, and sequelae is needed to inform clinical practice when COVID-19 emphasis shifts from eradication to living with the disease.
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New insights into Chlamydia trachomatis LGV diversity may help curb STI spreadA recent study emphasizes the genetic diversity within the ompA-genotype L2b clade, enhancing our understanding of sexually transmitted infections and how they are transmitted.
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SIGA Technologies' Trial Results Benefits Mpox Treatment Despite Not Meeting Primary EndpointThe impact of including patients with advanced disease and the role of comprehensive care in the PALM 007 clinical trial, which evaluated the antiviral tecovirimat for treating monkeypox in the Democratic Republic of the Congo.
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Community-Acquired Candida Glabrata Empyema: An Atypical Diagnosis Not to MissAlthough this patient had none of these common risk factors associated with Candida empyema, she did have other factors predisposing her to fungal colonization and subsequent infection.
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Management of Refractory Mpox in Patients Living with HIVTimmy Do, PharmD, BCIDP, BCPS, presents case series at MAD-ID 2025 on investigational therapies following tecovirimat failure.
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IV Push Administration for Outpatient Parenteral Antimicrobial TherapyInvestigators designed a quasi-experimental pre- and post-intervention analysis comparing a pre-intervention cohort receiving IV drip antibiotic infusion with a post-intervention cohort receiving IVP administration.
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Climate Change is Disrupting Biocontrol of Invasive Spongy MothsRising temperatures and changing humidity are undermining natural pest control, putting North American forests at risk.
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The Significance of WHO Declaring Mpox a Global EmergencyMitch Wolfe, MD, former Chief Medical Officer of CDC, offers some insights on mpox including the benefits of declaring a global emergency, disease transmission, and considerations for both the US public and clinicians.
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Barriers to Health Care Transition in Adolescents and Young Adults With Early Acquired HIV InfectionUnique challenges can affect the success of the shift from pediatric to adult care settings.
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Debating the Value of Incorporating Antibiotic Stewardship Principles Into Infection GuidelinesSignificant value can be offered through the incorporation of stewardship concepts into infection guidelines, but we must also address the risk and challenges it may impose on health care systems.
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Multidisciplinary Perspectives on HIV TreatmentA multidisciplinary panel concludes a discussion on best practices for managing patients with HIV in various healthcare settings and overcoming social health disparities.
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SURE1 and REASSURE Trials Paved Way for FDA Approval of OrlynvahCorey Fishman and Steven Aronin, MD, discussed trial highlights of Orlynvah for uncomplicated urinary tract infections and outlining plans to seek partners for a market launch to address antibiotic resistance and enhance patient treatment options.
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Top 5 Tips for Teaching ID LearnersThe latest article from SIDP offers a Top 5 list of how to precept a learner on an infectious disease rotation.
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Combination Antifungal for Invasive Mucormycosis: Yay or Nay?There is limited and conflicting data regarding the role of combination antifungal therapy for treatment of invasive mucormycosis.
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Maternal COVID-19 Vaccination, Infection Boosts Infant Antibody ResponseNatural infection plus COVID-19 vaccination in pregnant mothers conferred more durable antibody responses in infants than natural infection alone.
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What to Expect With Influenza in the Era of COVID-19Here are some insights into this upcoming 2021-2022 influenza season as well as concerns of the twindemic and addressing both the seasonal and pandemic viruses simultaneously.
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Vaxart's Oral Norovirus Vaccine: Key Study Findings and Future PlansSean Tucker, PhD, highlights effective immune response and mucosal immunity, paving the way for broader applications in viral disease prevention.
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HIV and Aging in the Era of Antiretroviral Therapy: Considerations in Clinical CareWith the population of adults with HIV growing older, incorporating age-based screenings, comprehensive assessments, and morbidity management into routine HIV care is essential in improving health outcomes and quality of life.
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The Lingering Threat: Managing Severe COVID-19 in the Postpandemic EraAlthough COVID-19 has receded quite a bit from the minds of many, it still remains a virus that can present serious morbidity and mortality. Here is a review of clinical treatment strategies by an intensivist when seeing patients with severe COVID-19.
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What We Know But Still Have to Learn About Long COVIDDespite advances in understanding and treating Long COVID, many questions about its mechanisms, susceptibility, and varied recovery patterns remain unresolved, underscoring the need for continued research.
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The Importance to Address and Help Visceral Adiposity in HIV PatientsDavid Wohl, MD, explains the health risks of visceral fat and the role of treatments like Tesamorelin F8 in managing the condition.
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Do We Have New Data for Optimal Treatments of Candida-Related Prosthetic Joint Infections?The choice between debridement and implant exchange affects treatment outcomes for Candida-related prosthetic joint infections, highlighting the need for standardized guidelines and further research.
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Clinical Considerations in Conducting Antifungal Susceptibility TestingAccess to antifungal susceptibility testing (AFST) remains limited in the United States. Therefore, providers must recognize clinical situations where AFST will provide its greatest value. In the latest article from SIDP, infectious disease pharmacists offers some insights on this subject.
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A Case of Mycobacterium Chimaera Infective EndocarditisNonspecific, nondolent symptoms make this disease difficult to diagnose.
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Screen Saver: Simpler, Less Costly Virus Testing in High-Risk SettingsScreening for an immunological biomarker in the nasal passage can effectively rule out a respiratory virus — reducing the need for conventional PCR tests.
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A Review of the Currently Available Monoclonal Antibodies for COVID-19Outside of vaccines, these underutilized therapies are the best defense against severe disease.
