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Where Do We Draw the Line? Duration of Antibiotic Therapy Varies for Bloodstream InfectionsWith potential delays in treatment, bloodstream infections can be concerning for clinicians. Here is a review of the literature that offer guidance for treatment.
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Strengths and Limitations of T2Candida Implementation From an Antimicrobial Stewardship PerspectiveThis novel, rapid diagnostic assay uses polymerase chain reaction and magnetic resonance to identify the 5 most common Candida species.
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Considering a Beta Lactam as Adjunctive Therapy for Staphylococcus aureus Early in TreatmentThis bacteremia can present heterogeneously and be difficult to contain, especially in an older patient population. Daniel B. Chastain, PharmD, BCIDP, AAHIVP, FIDSA, reviews the data of this class of therapies and how it may be clinically beneficial in combination with other antimicrobials.
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HIV Education and Advocacy in an Age of UncertaintyJoseph Cherabie MD, MSc, explains the importance of how these 2 components go hand-in-hand, and what it means to continue forward in spite of being in an unpredictable time.
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What Is a Better Treatment Approach for Immunocompromised Hosts With Clostridioides difficile Infection?Here is a review of the effectiveness of fidaxomicin vs vancomycin for CDI treatment in populations with immunocompromised conditions.
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Survey Highlights Critical Role of Pharmacists in HCV ManagementSurvey data show pharmacists are integral to HCV screening and treatment across healthcare settings, highlighting their contributions to HCV elimination efforts.
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mRNA Capping: A Component That Protects the COVID-19 Vaccine and Lends to its EffectivenessKate Broderick, PhD, molecular geneticist, discusses the mRNA capping technology and how it helps create stability to mRNA molecules within vaccines and guides them to cells.
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Recent Research Indicates That We're Falling Short on HBV Elimination TargetsOrganizations look at an agent-based model to assess the impact of vaccination, screening, and treatment on incidence and prevalence of HBV in Ontario, Canada.
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Safety and Immunogenicity Results For Mpox Vaccine MVA-BN in Adolescents Amid Rising ConcernsBuddy Creech, MD, MPH, assures that the interim findings of the study indicate adolescents produced a stronger immune response compared to adults, with minimal adverse effects.
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The Variety of Variants in COVID-19The evolution of the major variants, including the delta mutation.
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CRAB-By No More?Understanding the potential and limitations of new Acinetobacter baumannii active therapies.
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Practice Pearls for Treatment of Respiratory InfectionsTina Tan, MD; Wendy Wright, DNP, ANP-BC, FNP-BC, FAANP, FAAN, FNAP; Priya Nori, MD; Jacinda Abdul-Mutakabbir, PharmD; and Kevin Michael Reiter, MD, PA, provide key takeaways from the discussion on the treatment of respiratory viral infections.
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HIV CRISPR Therapy Fast-Tracked by the FDAThe phase 1/2 trial evaluating EBT-101 dosed its first patient in September 2022.
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Operation Warp Speed: Bringing Out the Best in America’s Ability to InnovateMatthew Hepburn, MD, offers some insights on his time as vaccine development lead for Operation Warp Speed and the ability to develop a COVID-19 vaccine within a year.
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The US Will Transition to Trivalent Vaccines for Next Year's Influenza SeasonSince changes in vaccine composition can sometimes lead to confusion or misinformation, effective communication is crucial to promote vaccine uptake.
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Expanded Treatment Options for Multi-Drug Resistant Infections in ChildrenIn the latest article from SIDP, here is a look at therapy options addressing this emerging clinical challenge.
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UTIs: Why Did You Have to Go and Make Things so Complicated?Although hospitalizations due to urinary tract infections have increased, there are some investigational antibiotics in clinical trials. Here is a review of some of these therapies in the pipeline.
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From Pandemic to EndemicA research agenda focusing on breakthrough infections, reinfections, severity, and sequelae is needed to inform clinical practice when COVID-19 emphasis shifts from eradication to living with the disease.
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New insights into Chlamydia trachomatis LGV diversity may help curb STI spreadA recent study emphasizes the genetic diversity within the ompA-genotype L2b clade, enhancing our understanding of sexually transmitted infections and how they are transmitted.
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SIGA Technologies' Trial Results Benefits Mpox Treatment Despite Not Meeting Primary EndpointThe impact of including patients with advanced disease and the role of comprehensive care in the PALM 007 clinical trial, which evaluated the antiviral tecovirimat for treating monkeypox in the Democratic Republic of the Congo.
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Community-Acquired Candida Glabrata Empyema: An Atypical Diagnosis Not to MissAlthough this patient had none of these common risk factors associated with Candida empyema, she did have other factors predisposing her to fungal colonization and subsequent infection.
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IV Push Administration for Outpatient Parenteral Antimicrobial TherapyInvestigators designed a quasi-experimental pre- and post-intervention analysis comparing a pre-intervention cohort receiving IV drip antibiotic infusion with a post-intervention cohort receiving IVP administration.
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Climate Change is Disrupting Biocontrol of Invasive Spongy MothsRising temperatures and changing humidity are undermining natural pest control, putting North American forests at risk.
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The Significance of WHO Declaring Mpox a Global EmergencyMitch Wolfe, MD, former Chief Medical Officer of CDC, offers some insights on mpox including the benefits of declaring a global emergency, disease transmission, and considerations for both the US public and clinicians.
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Barriers to Health Care Transition in Adolescents and Young Adults With Early Acquired HIV InfectionUnique challenges can affect the success of the shift from pediatric to adult care settings.
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Debating the Value of Incorporating Antibiotic Stewardship Principles Into Infection GuidelinesSignificant value can be offered through the incorporation of stewardship concepts into infection guidelines, but we must also address the risk and challenges it may impose on health care systems.
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Multidisciplinary Perspectives on HIV TreatmentA multidisciplinary panel concludes a discussion on best practices for managing patients with HIV in various healthcare settings and overcoming social health disparities.
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SURE1 and REASSURE Trials Paved Way for FDA Approval of OrlynvahCorey Fishman and Steven Aronin, MD, discussed trial highlights of Orlynvah for uncomplicated urinary tract infections and outlining plans to seek partners for a market launch to address antibiotic resistance and enhance patient treatment options.
