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Rifaquizinone: A Novel Rifamycin-Quinolone Hybrid AntibioticRifaquizinone is a dual-pharmacophore antibiotic combining rifamycin and a fluoroquinolone-like compound, showing strong bactericidal activity against resistant Staphylococcus aureus strains and biofilms, with promising results for treating prosthetic joint infections (PJI) but limited oral bioavailability.
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Decoding Malaria Parasites to Aid in Potential Treatments and VaccinesThe Johns Hopkins Malaria Research Institute’s work in this area is looking to find ways to identify, for the first time, every single gene in the genome of malaria parasites, which could lead to the development of new treatments or vaccines.
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Molecular Diagnostics for Bacterial Pneumonia Need Testing StewardshipOngoing education and proven outcomes need to aid this form of testing.
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An Update on LenacapavirThis new antiretroviral with a unique mechanism of action may be lifesaving for those with treatment-resistant HIV infection.
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mRNA COVID-19 Vaccines and Turbo Cancer: The Latest Myth That Won’t DisappearThe continuation of misinformation and disinformation being disseminated in the public is causing more public health communication issues as mistruths associate the vaccines with cancer.
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To Prophylax or not to Prophylax: Preventing CDIClinicians look at optimal approaches for trying to avoid Clostridioides difficile infection (CDI).
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From Pathogen to Infectious Disease Diagnosis: Test Determines Between Bacterial and Viral Infections in 15 MinutesMeMed CEO Eran Eden, PhD, discusses the MeMed BV test and how it can help make the distinction between the types of infections, aid in patient management, and reduce antimicrobial resistance.
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What's New In 2024: From the CLSI Subcommittee on Antimicrobial Susceptibility TestingThe Clinical and Laboratory Standards Institute (CLSI) Subcommittee on Antimicrobial Susceptibility Testing had its series of meetings to update breakpoints for a variety of classes of antimicrobials.
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So You Made the Decision to Implement Vancomycin AUC Dosing. Now What?Since the vancomycin guideline update, institutional leaders have been faced with the challenge of implementing and monitoring AUC-guided dosing.
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AI as a Tool to Support Clinicians, Not Replace ThemSharmeen Roy, PharmD, BCPS, on artificial intelligence (AI) in improving decision-making, reducing adverse drug events on National Adverse Drug Event Awareness Day, and upcoming research on pediatric dosing at the the Congress of the European Society of Clinical Microbiology and Infectious Diseases.
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Outpatient Antimicrobial Stewardship: The Keys to Developing a Successful ProgramThis form of stewardship can reduce unnecessary antibiotic prescribing, reduce costs, and optimize patient outcomes.
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Going Viral on Social Media: Integrating Digital Tools into Pharmacy RotationsIn the latest Bench to Bedside column, 2 clinicians discuss the benefits of utilizing social media for learning.
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Bad Bugs, New Drugs: A Discussion of Selected New Therapeutics From IDWeek 2022Cefepimetaniborbactam may represent a safe and effective carbapenemsparing agent in cUTI and AP, whereas ridinilazole may play an important role in treating CDI.
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While Hospital-Acquired C difficile Cases Have Decreased, Community-Acquired Cases Have RisenJoseph Zackular, PhD highlights targeting high-risk groups for vaccination and shares insights into the future of mRNA vaccine development for C diff.
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Tricky Infusion Issues and Potential Solutions: OPAT EditionOutpatient parenteral antimicrobial therapy (OPAT) offers benefits for patients as well as providing cost effectiveness; however, it is not without its challenges. Two clinicians provide insights on this modality.
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Treating Zaire ebolavirus With Ansuvimab-zyklThe recombinant human IgG1κ monoclonal antibody binds and neutralizes the virus.
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Will the Melting Permafrost Uncover Vector Borne and Zoonotic Pathogens and Release Ancient Infectious Diseases?With melting ice and the release of ancient viruses, there are concerns around the emergence of potentially unknown infectious diseases. Emily Jenkins PhD, DVM, BScHon, offers insights on “zombie viruses” and says polar bears might hold the key to understanding what lies ahead, and how a One Health approach may help in surveillance and prevention.
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Reduced-Dose Trimethoprim-Sulfamethoxazole Effective in Treating Mild to Moderate Pneumocystis jirovecii PneumoniaHere is a review of using this therapy in this patient population.
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New Recommendations for Antibiotic Prophylaxis Prior to Dental ProceduresThe American Dental Association (ADA) has updated patient profiles on who should be indicated for antibiotic prophylaxis.
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Long-Acting Injectable HIV Therapy: Addressing Adherence ChallengesElizabeth Hastie, MD discussed the LATITUDE trial results, highlighting the need for wider access to this treatment, especially for those not virally suppressed, and could help shape future healthcare guidelines.
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Precision Dosing of To-Marrow: Linezolid Therapeutic Drug MonitoringEmerging literature suggests therapeutic drug monitoring for this antimicrobial to minimize the risk for linezolid-associated toxicities while maintaining efficacy in select populations.
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Bugworks' Antibiotic BWC0977 Targets Resistant PathogensBala Subramanian, PhD, highlights how the novel antibiotic BWC0977, with its dual intravenous and oral formulation, is poised to transform the fight against antimicrobial resistance.
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Will We Ever See Oral Carbapenems for ESBL Urinary Tract Infections?Recent issues surrounding the ADAPT-PO and SURE-2 trials place the spotlight on the difficulties developing oral carbapenem-based antibiotics and case their future into doubt.
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From Single-Use to Multi-Use: A Brief Review of N95 Respirator Decontamination StrategiesThis indispensable personal protective equipment did come up in short supply and reuse strategies has become a topic of great interest and research.
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Unveiling Gender Disparities in Lyme Disease: A Critical Analysis of Persistent IllnessVery few Lyme disease studies consider sex- and gender-based differences. Is this flawing the research?
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PrEP State of the Union: Adherence, Access, Uptake IssuesAlthough this form of prophylaxis is highly protective, there are situations in which breakthrough infections occur.
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Antibiotic De-Escalation: Is This the Right Outcome Measure?The proposed clinical benefits of de-escalation has contributed to its lukewarm adoption in some settings. This article looks at the challenges in measuring the impact of de-escalation, and the ongoing search for more meaningful metrics to evaluate the success of antimicrobial stewardship (AMS) programs.
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Ceftriaxone as Definitive OPAT for MSSA Bloodstream InfectionsA cautious approach for now is warranted as well as a need for a randomized clinical trial.
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Employee Health After the COVID-19 Pandemic: Stronger Than YesterdayFor providers on the front lines, lessons learned can help inform strategies to enhance the protection of their health going forward.
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Measles: The Canary in the Coal Mine for Childhood Vaccine DeclineOn the heels of the first death in an ongoing US-based measles outbreak, Paul Offit, MD, discusses how outbreaks are the first sign that childhood vaccination rates are starting to decline.
