Skin & Soft Tissue Diseases

There is currently no FDA-approved treatment for molluscum contagiosum, but topline positive results from 2 phase 3 trials of an investigational drug look to be promising.

Investigators say a bacteriophage trial that was cut short due to the therapy’s slow effect on infected burns still yielded important insights.

The recent death of a nasal irrigation user may have more to do with dirty water and/or improper use of the device, rather than a flaw with the approach.

Despite increased research and investigations, the cause of the spike in cases of AFM in the United States remains unknown.

The synthetic novel tetracycline offers a new option for complicated intra-abdominal infections.

Freeze-drying vaccines enables health officials to get vaccines to remote areas, but until now, it has not been possible for the fragile polio vaccine.

The new test is approved to assist with detecting cytomegalovirus in newborns less than 21 days of age.

Polio could soon be completely eradicated, but public health officials have an intricate set of steps to ensure a lasting defeat.

New outbreaks of rubella and troubling data on influenza highlight the importance of vaccination.

Herpes simplex virus type 1 is associated with a higher risk of Alzheimer’s disease, yet the antivirals prescribed to treat the infection may reduce the risk of dementia.

A recent report has described a case of wound infection with the bacterium Burkholderia thailandensis in a woman in Arkansas.

The stage may finally be set for the phage therapy era for recalcitrant bacterial infections.

Results indicate patients who received single-dose oritavancin were significantly less likely to be hospitalized, compared to those who received multidose vancomycin.

Instead, increasing duration of postoperative antimicrobial prophylaxis is associated with higher odds of acute kidney injury and C diff infection in a dose-dependent manner.

Delafloxacin was found to be relatively safe and well tolerated in patients with acute bacterial skin and skin structure infections with past or present cardiac or vascular difficulties.

Nonadherence to antiretroviral therapy was associated with a higher risk of death.

Plenty of research has gone into the causes and progression of Alzheimer’s disease. Now a new effort aims to make the case that scientists have been looking in the wrong direction.

Patients with diabetes who were treated for acute bacterial skin and skin structure infections (ABSSSIs) with iclaprim had fewer adverse events (AEs) than those who were treated with vancomycin, according to the results of a recent study.

Yoav Golan, MD, discusses the paradigm shift occurring in treatment for ABSSSI and how to motivate clinicians to buy into new programs and protocols.

Common skin bacteria have gained resistance to multiple antibiotics.

Rezafungin, an investigational antifungal, demonstrated significant activity against Aspergillus in an in vitro study.

A social media campaign initiated in Russia may be sowing the seeds of debate surrounding vaccine safety, causing new outbreaks of measles globally.

Additional evidence supports the use of oritavancin as a cost-saving outpatient treatment for acute bacterial skin and skin structure infections (ABSSTIs) in patients who would otherwise be admitted to the hospital for therapy.

In a wounded mouse model concurrently infected with influenza A, investigators observed that the innate immune system prioritized responding to the lung infection, delaying wound healing.

Bruce Jones, PharmD, BCPS, discusses the growing burden of ABSSSI and why there have been an influx of MRSA cases.

There is a new treatment for this old disease, so why are we still worried?

Yoav Golan, MD, discusses trends in the incidence of acute bacterial skin and skin structure infections, standard protocols for treatment, and the challenges clinicians continue to face.

New geographical spread of the disease may warrant increased vigilance among labs and clinicians.

The PDUFA action date has been set for February 13, 2019.

The FDA advisory committee voted 17 to 1 in favor of omadacycline for treatment of ABSSSI and 14 to 4 for the treatment of CABP.