SPOTLIGHT -
Baloxavir Marboxil Significantly Reduces Time to Improvement of Flu Complications
The phase 3 CAPSTONE-2 trial shows treatment with baloxavir marboxil significantly reduced the time to improvement of flu symptoms compared with placebo.
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CDC Investigating Increase in Polio-like Illness Reported Throughout the United States
From August 2014 to September 2018, the CDC received information on a total of 386 confirmed US cases of a polio-like illness occurring mostly among children.
Cytomegalovirus Vaccine Candidate Found to Be Safe & Immunogenic in First-in-Humans Trial
An eVLP cytomegalovirus (CMV) vaccine was found to be safe and immunogenic at very low doses in healthy seronegative adults.
Switch to D/C/F/TAF Results in Maintained High Virologic Suppression in Adults with HIV
Long-term safety and efficacy data from the pivotal phase 3 EMERALD trial were presented at ID Week 2018.
Adding Fosfomycin to Daptomycin Could Improve Outcomes of MRSA Bacteremia
The combination of daptomycin plus fosfomycin was more effective than daptomycin alone for treating patients with MRSA bacteremia.
Increasing Duration of Surgical Prophylaxis Does Not Decrease Odds of SSI
Instead, increasing duration of postoperative antimicrobial prophylaxis is associated with higher odds of acute kidney injury and C diff infection in a dose-dependent manner.
Incidence of Candidemia is Decreasing, But Not for Some Drug-Resistant Species
First large-scale study on trends in invasive candidiasis finds species distribution of isolates varied between blood and nonblood sterile sites.
Analysis Underscores Substantial Burden of Candidemia in the United States
A new analysis details the substantial burden of candidemia in the United States and calls for ongoing surveillance efforts to help assess the impact of prevention interventions.
Severe Influenza May Be a Risk Factor for Aspergillosis
Over one-third of patients with invasive aspergillosis lacked a documented immunosuppressive condition.
Patients with Carbapenem-Resistant Bloodstream Infections Less Likely to Survive Hospitalization
New research finds patients with carbapenem-resistant bloodstream infections have a lower likelihood of surviving hospitalization or being discharged home.
HIV-Positive Patients at Higher Risk of Late Mortality Following Cryptococcal Infection
Nonadherence to antiretroviral therapy was associated with a higher risk of death.
Congenital Syphilis Cases in United States Reach 20-Year High
A new report from the CDC underscores the need for all pregnant women to receive early prenatal care that includes syphilis testing at their first visit.
FDA Grants QIDP & Fast Track Designations to Rezafungin Prophylaxis Development Program
The FDA has granted QIDP and fast track designations to Cidara Therapeutics’ prophylaxis development program for rezafungin, their lead antifungal product candidate.
Iclaprim Shows Consistent, Potent Activity Against Beta-Hemolytic Streptococci
Investigators find iclaprim to be active against a worldwide collection of drug-susceptible and drug-resistant beta-hemolytic streptococci from patients with skin and skin structure infections.
Global Containment Efforts Integral to Poliovirus Eradication
If poliovirus is not securely contained, release of the virus can result in reestablishment of endemic or epidemic poliovirus transmission.
Ceftolozane & Tazobactam Proves Noninferior to Meropenem in Patients with HABP or VABP
Ceftolozane and tazobactam proves noninferior to meropenem in a pivotal phase 3 trial of adult patients with HABP or VABP.
E coli Strain Found in Poultry Linked with Urinary Tract Infections in Humans
Investigators have found that a strain of E coli found in retail poultry products can cause a wide range of infections in people.
Telavancin Promising Potential Treatment Option for MRSA in Cystic Fibrosis Patients
Investigators find telavancin has potent in vitro activity and low resistance development potential when used against S aureus isolates in patients with cystic fibrosis.
CDC Reports Sharp, Sustained Increase in STDs Over the Past 4 Years
A new analysis from the CDC shows steep and sustained increases in STDs in recent years.
Benefits of Antimicrobial Stewardship Programs in Hemodialysis Facilities
A new analysis details the potential clinical and economic benefits of implementing antimicrobial stewardship programs in hemodialysis facilities.
Increase in US Listeriosis Outbreaks Linked to Cheeses Made Under Unsanitary Conditions
Since 2006, the number of reported US listeriosis outbreaks associated with cheese made under unsanitary conditions has increased.
Health Care Providers Should Consider Rat Lungworm in Patients with Eosinophilic Meningitis
Health care providers, especially those practicing in the southern United States, should consider angiostrongyliasis in patients with eosinophilic meningitis.
Addressing Disparities In Achieving Viral Suppression Critical to Ending US HIV Epidemic
Closing treatment gaps is critical to ending the HIV epidemic in the United States.
CDC Reports Over 100 Cases of Measles Across 21 States
A total of 107 cases of measles has been reported thus far this year in the United States and the District of Columbia, underscoring the importance of vaccination.
Long-Acting Injectable 2-Drug HIV Treatment Regimen Proves Noninferior to Standard of Care
A phase 3 trial has met its primary endpoint, showing a similar efficacy of a once-a-month injectable 2DR of cabotegravir and rilpivirine compared to daily, oral 3DR.
New Aggressive Tick Species Is Spreading Through the United States
A species of tick that is native to Australia, New Zealand, and eastern Asia, has been springing up in several US states this summer.
FDA Advisory Committee Votes in Favor of ALIS to Treat NTM Lung Disease Caused by MAC
If approved, ALIS will be the first and only therapy available in the United States that will be specifically indicated for the treatment of patients with NTM lung disease caused by MAC.
FDA Warns Azithromycin Increases Risk of Cancer Relapse After Donor Stem Cell Transplant
The FDA has issued a warning that azithromycin should not be used to prevent bronchiolitis obliterans syndrome in patients with hematologic malignancies who undergo HSCT.
HIV Testing Programs Needed in Southern US to Improve Black MSM Linkage to Care
A new CDC analysis underscores the need for HIV testing programs in the southern part of the United States to improve linkage medical care among HIV-positive black men who have sex with men (MSM).
Using A "Kick and Kill" Approach to Cure HIV
Investigators report results of the first randomized clinical trial to test a novel strategy to wake up and kill dormant HIV hiding in reservoir cells.
