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A Plea for New Guidance and Research: Low-Level Viremia in Persons Living With HIVCurrent guidelines and primary literature for managing persons living with HIV who have persistently low levels of HIV RNA are scarce. Considering the risks associated with this phenomenon, a call for further guidance and more robust studies are needed for these patients.
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Understanding the Nuances of the RSV Maternal Vaccine and Monoclonal Antibody for the Pediatric PopulationWith the approval of newer products, clinicians have tools to prevent the respiratory virus in the most vulnerable population. Helen Chu, MD, MPH, offers some insights on their efficacy and the nuances of the delivery of the 2 immunizations.
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The Next Generation of COVID-19 Vaccines and BoostersWill there be an answer to keep the continuously evolving virus at bay? Are seasonal combination vaccines the wave of the future?
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Revisiting Old Foes: Updates on HSVHerpes simplex viruses are chronic infections that underscore racial and ethnic disparities and are afflicting adolescents in increasing numbers.
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“Triple Therapy” Facing Triple ThreatClinicians provide an overview of intraamniotic infections and offer treatment strategies for these challenging infections.
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CDC Updates Pneumococcal Conjugate Vaccine RecommendationsThe federal agency recommends using either PCV13 or PCV15 as part of a 4-dose series for pediatric patients between the ages of 2-59 months.
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Antimicrobial Stewardship: How to Extend a Solid HandshakeIn the latest column from SIDP, handshake stewardship prioritizes face-to-face communication between frontline providers to enable feedback to assess the appropriateness of prescribed antimicrobials.
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Secnidazole Offers Hope as Option for Treating Trichomoniasis in WomenThis nitroimidazole antibiotic is shown to be efficacious for this condition.
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Antibiotic Stewardship in Outpatient CareAlthough there are challenges for clinical and infectious disease pharmacists when trying to apply this concept, here are some considerations and strategies to employ stewardship in this setting.
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Long-Acting Lipoglycopeptides for the Treatment of Severe InfectionsLong-acting lipoglycopeptides (LGPs) like dalbavancin, oritavancin, and telavancin were developed with extended half-lives, initially targeting acute bacterial skin and skin structure infections (ABSSSIs). However, recent studies have explored their potential in treating other infections, including infective endocarditis (IE), bone and joint infections (BJIs), and bloodstream infections (BSIs), offering an alternative to standard care and outpatient antimicrobial therapy.
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340B Drug Pricing Program: What Is It and Why Is It Important?The 340B program has had a great impact on access to HIV treatment and prevention services in the US.
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Mixed Fungal Brain AbscessClinicians review a patient case including diagnosis, treatment, and follow-up.
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MRNA COVID-19 Vaccines and Male FertilityAccording to a small study, the Moderna and Pfizer COVID-19 vaccines do not impact male fertility.
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Multidisciplinary Perspectives on HIV TreatmentA multidisciplinary panel concludes a discussion on best practices for managing patients with HIV in various healthcare settings and overcoming social health disparities.
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COVID-19 Booster Shots and the FutureKey opinion leaders provide some advice for the public regarding COVID-19 booster shots and look to the future of the pandemic.
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Long-Acting Antiretroviral Therapies for HIV Treatment and PreventionMore treatment options and modalities are now available for patients.
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Longhorn Vaccines Develops Sepsis Vaccine Targeting Key ToxinsThis composite peptide vaccine targets key bacterial toxins to prevent sepsis, enhance antibiotic efficacy, reduce inflammation in diseases and cancer, with further data expected soon.
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Identifying Disparities in Sepsis Diagnosis for Unbiased CareRisk of inaccuracy with pulse oximeters and clinician knowledge gaps in people of color may affect sepsis evaluations and impact treatment plans.
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Future Directions for Managing COVID-19 and InfluenzaGeorge Loukatos, MD, shares clinical pearls for the management of the SARS-CoV-2 and influenza viruses.
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Challenges in the Management of Mycobacterium abscessus ComplexThis pathogen is the third most frequently isolated nontuberculous mycobacteria seen in the United States. Here is a review of how it presents and treatment options.
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Contemporary Issues on the Treatment of Women Living with HIV in the USThe increasing presence of multiple non-AIDS comorbidities in women and others living with HIV challenges clinicians to steer away from the approach of optimizing individual chronic conditions but to think more holistically.
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From Pandemic to EndemicA research agenda focusing on breakthrough infections, reinfections, severity, and sequelae is needed to inform clinical practice when COVID-19 emphasis shifts from eradication to living with the disease.
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So You Made the Decision to Implement Vancomycin AUC Dosing. Now What?Since the vancomycin guideline update, institutional leaders have been faced with the challenge of implementing and monitoring AUC-guided dosing.
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The ART of Implementing an Antiretroviral Stewardship ProgramBy addressing ART-related medication errors and increasing linkage to care, antiretroviral stewardship programs can improve management of inpatients with HIV.
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cUTI Roundtable: The Latest Therapeutic DevelopmentsThe third and final episode in our series looks at what is in the pipeline as well as a discussion around FDA guidance.
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What We Know But Still Have to Learn About Long COVIDDespite advances in understanding and treating Long COVID, many questions about its mechanisms, susceptibility, and varied recovery patterns remain unresolved, underscoring the need for continued research.
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A Long-Acting Injectable for the Treatment of Candida spp InfectionsIn the second installment of a 3-part series on long-acting injectables related to various infections, Caitlin Soto, PharmD, BCIDP, provides insights on using rezafungin for invasive candidiasis.
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Molecular Diagnostics for Bacterial Pneumonia Need Testing StewardshipOngoing education and proven outcomes need to aid this form of testing.
