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mRNA Capping: A Component That Protects the COVID-19 Vaccine and Lends to its EffectivenessKate Broderick, PhD, molecular geneticist, discusses the mRNA capping technology and how it helps create stability to mRNA molecules within vaccines and guides them to cells.
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Recent Research Indicates That We're Falling Short on HBV Elimination TargetsOrganizations look at an agent-based model to assess the impact of vaccination, screening, and treatment on incidence and prevalence of HBV in Ontario, Canada.
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The Variety of Variants in COVID-19The evolution of the major variants, including the delta mutation.
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CRAB-By No More?Understanding the potential and limitations of new Acinetobacter baumannii active therapies.
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Practice Pearls for Treatment of Respiratory InfectionsTina Tan, MD; Wendy Wright, DNP, ANP-BC, FNP-BC, FAANP, FAAN, FNAP; Priya Nori, MD; Jacinda Abdul-Mutakabbir, PharmD; and Kevin Michael Reiter, MD, PA, provide key takeaways from the discussion on the treatment of respiratory viral infections.
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HIV CRISPR Therapy Fast-Tracked by the FDAThe phase 1/2 trial evaluating EBT-101 dosed its first patient in September 2022.
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The US Will Transition to Trivalent Vaccines for Next Year's Influenza SeasonSince changes in vaccine composition can sometimes lead to confusion or misinformation, effective communication is crucial to promote vaccine uptake.
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Expanded Treatment Options for Multi-Drug Resistant Infections in ChildrenIn the latest article from SIDP, here is a look at therapy options addressing this emerging clinical challenge.
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UTIs: Why Did You Have to Go and Make Things so Complicated?Although hospitalizations due to urinary tract infections have increased, there are some investigational antibiotics in clinical trials. Here is a review of some of these therapies in the pipeline.
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From Pandemic to EndemicA research agenda focusing on breakthrough infections, reinfections, severity, and sequelae is needed to inform clinical practice when COVID-19 emphasis shifts from eradication to living with the disease.
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FDA Approves Combination Antibiotic for Treatment of Complicated Urinary Tract InfectionsCefepime-enmetazobactam (Exblifep, Orchid Pharma) was given the federal nod for the indication of treating complicated urinary tract infections (cUTI) in adults.
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SIGA Technologies' Trial Results Benefits Mpox Treatment Despite Not Meeting Primary EndpointThe impact of including patients with advanced disease and the role of comprehensive care in the PALM 007 clinical trial, which evaluated the antiviral tecovirimat for treating monkeypox in the Democratic Republic of the Congo.
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Community-Acquired Candida Glabrata Empyema: An Atypical Diagnosis Not to MissAlthough this patient had none of these common risk factors associated with Candida empyema, she did have other factors predisposing her to fungal colonization and subsequent infection.
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IV Push Administration for Outpatient Parenteral Antimicrobial TherapyInvestigators designed a quasi-experimental pre- and post-intervention analysis comparing a pre-intervention cohort receiving IV drip antibiotic infusion with a post-intervention cohort receiving IVP administration.
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The Significance of WHO Declaring Mpox a Global EmergencyMitch Wolfe, MD, former Chief Medical Officer of CDC, offers some insights on mpox including the benefits of declaring a global emergency, disease transmission, and considerations for both the US public and clinicians.
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Barriers to Health Care Transition in Adolescents and Young Adults With Early Acquired HIV InfectionUnique challenges can affect the success of the shift from pediatric to adult care settings.
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Multidisciplinary Perspectives on HIV TreatmentA multidisciplinary panel concludes a discussion on best practices for managing patients with HIV in various healthcare settings and overcoming social health disparities.
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Top 5 Tips for Teaching ID LearnersThe latest article from SIDP offers a Top 5 list of how to precept a learner on an infectious disease rotation.
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Combination Antifungal for Invasive Mucormycosis: Yay or Nay?There is limited and conflicting data regarding the role of combination antifungal therapy for treatment of invasive mucormycosis.
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Maternal COVID-19 Vaccination, Infection Boosts Infant Antibody ResponseNatural infection plus COVID-19 vaccination in pregnant mothers conferred more durable antibody responses in infants than natural infection alone.
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What to Expect With Influenza in the Era of COVID-19Here are some insights into this upcoming 2021-2022 influenza season as well as concerns of the twindemic and addressing both the seasonal and pandemic viruses simultaneously.
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HIV and Aging in the Era of Antiretroviral Therapy: Considerations in Clinical CareWith the population of adults with HIV growing older, incorporating age-based screenings, comprehensive assessments, and morbidity management into routine HIV care is essential in improving health outcomes and quality of life.
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Nonventilator Hospital-Acquired Pneumonia: Epidemiology, Prevention, and Where It Is NowThe management of hospital-acquired pneumonia requires use of preventive bundles, mitigative of risk factors, and prompt diagnosis with initiation of treatment when highly suspected.
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Clinical Considerations in Conducting Antifungal Susceptibility TestingAccess to antifungal susceptibility testing (AFST) remains limited in the United States. Therefore, providers must recognize clinical situations where AFST will provide its greatest value. In the latest article from SIDP, infectious disease pharmacists offers some insights on this subject.
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A Case of Mycobacterium Chimaera Infective EndocarditisNonspecific, nondolent symptoms make this disease difficult to diagnose.
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A Review of the Currently Available Monoclonal Antibodies for COVID-19Outside of vaccines, these underutilized therapies are the best defense against severe disease.
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Celebrating 30 Years: The Past, Present, and Future of the Society of Infectious Diseases Pharmacists (SIDP)Introducing “Bench to Bedside With SIDP,” a new column covering everything from antimicrobial stewardship and pharmacokinetics/pharmacodynamics to mentorship, preceptorship, and more.
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A Viral Colonial Legacy: HIV, Monkeypox Emerged Due to Ongoing Colonial Viral NeglectSimilar to HIV, the colonial and postcolonial history is fundamental to the biology of this monkeypox outbreak.
