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H5N1: The Outbreak the US Got Bored WithSince its detection in early 2024, H5N1 has spread to dairy cows, poultry, and wild birds. Political factors, including leadership changes at the Centers for Disease Control and Prevention and cuts to public health resources, have worsened the situation, leading to a weakened response.
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"Antibiotic Never Events": The Ideal Target to Reduce Antimicrobial ExposureBy stopping unnecessary antibiotics before they start, clinicians can avoid unnecessary harm to the patient and the population.
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Antiretroviral Stewardship: The Time is NowIn this narrative review of studies evaluating antiretroviral stewardship programs (ARVSPs), we propose core elements for ARVSPs that are based on published evidence, clinical experience, and adapted from antimicrobial stewardship programs.
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National HIV Testing Day: Free Screening Services Available at WalgreensTesting and information will be available at select Walgreens stores in more than 260 cities on National HIV Testing Day on Thursday between 10 am and 7 pm.
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E-cigarette Users, Especially Women, May Be More Susceptible to FluEarly research found that e-cigarette use affects the immune system response to the flu virus and the effects are different for female and male users.
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Is Greater BSA Use for Sepsis, Bacteremia Affecting HO-CDIs?An examination of broad-spectrum antibiotic use in this patient population is essential for developing strategies to mitigate the risk of these infections.
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"Antibiotic Never Events": The Ideal Target to Reduce Antimicrobial ExposureBy stopping unnecessary antibiotics before they start, clinicians can avoid unnecessary harm to the patient and the population.
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A Case of Varicella-Zoster Meningitis Causing Postoperative Fevers After Umbilical Hernia RepairDue to worsening headaches and unrevealing cross-sectional imaging and ascites fluid analyses, this patient's differential evolved toward a central nervous system source.
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Treating HCV in HIV-Coinfection: Still a Therapeutic Dilemma?Despite the availability of highly active agents against HCV, HIV-infected patients require special considerations for drug interactions when considering treatment options.
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Site-Specific Labeling Provides New Insight on Influenza Virus VariationA new method assessing the influenza A strain provides investigators with a more detailed look at influenza viruses.
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Febrile Finesse: Are We Employing Appropriate Empiric Coverage in Patients With Neutropenic Fever?Traditional therapy coverage does not include recent data that offers some updates in evaluating the current effectiveness of empiric antibiotic treatment.
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Individualized Beta-Lactam Therapy and MonitoringElevated beta-lactam concentrations have been associated with neurotoxic adverse effects, including seizures and mental status changes.
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A Chance to Improve Hepatitis C Care for PWIDHere is a review of an opportunistic treatment approach to HCV infection in this patient population in a European study and some of the potential challenges in applying it in the United States.
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Those With HIV Shown to Have More Coronary PlaqueEven if HIV-positive individuals have a low-to-moderate risk for cardiovascular disease, they still experience more coronary plaque.
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10 Key Pillars to an Effective Ebola ResponseEVD outbreaks this year serve as a reminder of the virus’ severity and the importance of having a containment strategy in place.
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Intravenous Antimicrobials: Is It Time to Push?Intravenous (IV) push is an attractive option to administer antimicrobial therapy to patients in an efficient and effective manner in a variety of clinical settings. While many advantages to IV push administration exist, clinicians should be mindful of available literature regarding safety profiles, pharmacokinetic/pharmacodynamic characteristics, and clinical data for IV push antimicrobial administration prior to utilizing it in specific patient populations.
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Oral Therapeutic Options to Prevent Disease Progression From COVID-19 in an Ambulatory SettingAs the number of COVID-19 cases continues to rise, oral treatment options for at-home use are in demand to provide early intervention and reduce the progression to severe disease, hospitalization, and death.
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Navigating Long COVID and ME/CFS OverlapAlba Azola, MD discusses the challenges of diagnosing and managing Long COVID and its overlap with ME/CFS, emphasizing the need for individualized care and ongoing research.
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Daptomycin as Frontline Therapy for MRSA Bacteremia: Has the Time Come?Findings increasingly suggest the mortality risk may be reduced by initiating daptomycin within 3 days of infection.
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Combating Misinformation on AntimicrobialsInsights from Catherine Bertrand Ferrandis, DVM, on the role of One Health and interdisciplinary collaboration.
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Phase II Study Shows Efficacy of 6-Month Regimen of Lenacapavir, Teropavimab, and Zinlirvimab for HIVOnyema Ogbuagu, MBBCh, FACP, FIDSA discussed 96% virologic suppression with lenacapavir-based therapy, showing similar results to daily oral regimens.
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Challenges and Implications of the V Quinn TB Prevention TrialGregory Fox, PhD outlines the trial's challenges, the impact of combining results with the TB Champ trial, and the role of collaboration in strengthening research outcomes.
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Treating Persistent Methicillin-susceptible Staphylococcus aureus (MSSA) BacteremiaEmerging treatment options for patients with persistently positive blood cultures with Methicillin-Susceptible Staphylococcus aureus (MSSA).
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Pandemic Public Health Policy and Trust: Did We Lose the Latter Through the Former’s Actions?In the second installment of our interview with Robert Hopkins Jr, MD, the medical director of the National Foundation for Infectious Diseases (NFID), he discusses some of the takeaways in how public health messaging was lost on the public, which lead to mistrust, and thus leaving open the door for disinformation and misinformation.
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The Tripledemic as a Precursor to Stakeholder Alignment under the Quintuple AimInfectious disease outbreaks will continue to increase and trying to find strategies to ensure providers are cared for to prevent burnout and shortage staffing is essential if another pandemic arises.
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A Plea for New Guidance and Research: Low-Level Viremia in Persons Living With HIVCurrent guidelines and primary literature for managing persons living with HIV who have persistently low levels of HIV RNA are scarce. Considering the risks associated with this phenomenon, a call for further guidance and more robust studies are needed for these patients.
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Understanding the Nuances of the RSV Maternal Vaccine and Monoclonal Antibody for the Pediatric PopulationWith the approval of newer products, clinicians have tools to prevent the respiratory virus in the most vulnerable population. Helen Chu, MD, MPH, offers some insights on their efficacy and the nuances of the delivery of the 2 immunizations.
