Cidara Therapeutics has developed CB-012, a stable conjugate of a highly potent antiviral agent linked to human IgG1 Fc, and investigators are evaluating the asset for the treatment and prevention of seasonal and pandemic influenza A and B infections.
The ASPECT-NP trial compared a new 3-gram dose regimen of ceftolozane/tazobactam versus meropenem in the treatment of ventilated nosocomial pneumonia.
Investigators found increased mortality in the combination arm where 21% of patients died vs 16% in the standard therapy arm, although the number of patients with persistent bacteremia at day 5 in the combination arm was significantly reduced compared with standard therapy.
A UK-based study team conducted an evaluation of real-time penicillin monitoring via minimally invasive, microneedle-based penicillin biosensor.
A study found that the molecule, Compound A, has potent activity against Acinetobacter Pneumonia in mice possibly by a dual killing mechanism and by reducing lipopolysaccharide-induced vascular leak.
Rezafungin achieved greater and more prolonged penetration at sites of intra-abdominal candidiasis than micafungin, which correlates with significantly greater activity against FKS-mutant Candida glabrata clinical strains.
A study found that eracavycline was 2-4-fold more active than tigecycline against isolates that produced ESBL and at least 8-fold more active than tigecycline against A baumannii.
Investigators detail the activity of cefiderocol, a novel parenteral siderophore cephalosporin, against carbapenem-resistant clinical isolates.
An Italian study found that immunization rates are high among health workers, but an important proportion of employees are not immune to mumps.
In a study of hospitalized patients across Europe, oritavancin (MIC50/MIC90, 0.03/0.06 mg/L) inhibited all S aureus isolates at ≤0.12 mg/L (susceptible breakpoint).
Ignacio Martin-Loeches, MD, PhD, discusses the efficacy outcomes of the ASPECT-NP trial evaluating ceftolozane/tazobactam for the treatment of nosocomial pneumonia.
What is the key to success that helped a Spanish hospital achieve an 80% reduction in global incidence of catheter-related bloodstream infections and sustain it over an 8-year period?
A study reports that daily infectious disease consults reduced the consumption of antimicrobials when compared with weekly consultations, especially in the emergency department.
Jose Arribas, MD, discusses the challenges in the field of long-acting injectable therapy for the treatment, management, and even prevention of HIV.
A large percentage (96%) of health care worker respondents reported feeling confident in their knowledge of antibiotic resistance, but only 60% answered the 7 key questions correctly.
In a symposium at ECCMID 2019, Giovanni Rezza, MD, highlighted the growth of tropical outbreaks occurring in Europe and discussed how warmer temperatures may lead to more frequent tropical outbreaks.
On April 12, 2019 a recall was issued by Caito Foods for pre-cut watermelon, honeydew melon, cantaloupe, and pre-cut fruit medley products.
After receiving treatment with ibrexafungerp, a patient with esophageal candidiasis gradually improved and by day 54 he was completely asymptomatic.
Investigators on the CapU3 study concluded that urinary HPV testing may be a good alternative to Pap smear for some women.
Here is a look at infectious disease related US Food and Drug Administration news from the week of April 7, 2019.
We’ve rounded up a list of important US Food and Drug Administration (FDA) and US Department of Agriculture (USDA) recalls from this past week.
Investigators from the University of Sherbrooke found some bacterial strains of C diff are likely associated with mortality in C diff infection, specifically, NAP1/BI/R027.
An 18-year retrospective cohort study of 130 hospitals in the US Veterans Health Administration system revealed a significant reduction in cases of hospital-onset candidemia. But what caused the drop?
A new study has uncovered that only one-third of patients who present to the emergency department with suspected UTI have evidence of infection, yet the majority receive antibiotics.
MDROs were detected in 334 (22%) curtain cultures from 6 skilled nursing facilities in southeast Michigan.
Stay up-to-date on the latest infectious disease news by checking out our top 5 articles of the week.
Subcutaneous implants are 1 promising strategy to address suboptimal adherence to pre-exposure prophylaxis (PrEP) for HIV, and a recent in silico simulation examined pharmacokinetic profiles and safety of tenofovir alafenamide implants.
A new study showed no statistically significant reduction in clinical cultures between chlorhexidine bathing and routine care.
With the proper use of antiretroviral therapy and pre-exposure prophylaxis, the risk of HIV transmission has never been lower. So why do some practitioners hesitate to endorse condomless sex?
Physicians with higher than average antibiotic prescription rates tended to be more cautious after being shown how their prescribing habits compared with those of colleagues.