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GASTROINTESTINAL INFECTIONS

We asked a simple question to our IDWeek experts: has COVID-19 taken attention away from any greater infectious disease issues?

The Forgotten Infectious Disease Issues During COVID-19

A third of patients hospitalized with community-onset Clostridioides difficile infections had recently been discharged from the same hospital, and most of those received antibiotics, according to research presented at IDWeek.

Prior Hospitalizations Associated With Readmission with CDI

Hospital Exposure to Antibiotics Associated with C diff Pose Higher Risk of MDRO 

Invasive C  glabrata found to be most prevalent strain of Candida in stool of patients with C difficile infection, and likely resistant to caspofungin. 

Invasive Candidiasis with C diff is Likely Resistant to Antifungal

Multidrug-Resistant Infection is Diverse, Frequent in Hospital Setting

An antiprotozoal used in veterinary medicine demonstrates potential for  repurposing to replace metronidazole to treat Clostridioides difficile.

Repurposing a Veterinary Antiprotozoal to Replace Metronidazole for C difficile

The 2-step algorithm for diagnosing Clostridioides difficile infection is difficult to interpret in patients who have cancer or are immunocompromised.

Diagnostic Algorithm for C Diff Is Confounded in Cancer Patients

Administration of the investigational oral microbiome therapeutic SER-109 resulted in a statistically significant decrease in the proportion of patients who had C diff recurrence within 8 weeks of administration versus placebo.
 

Positive Topline Data From Phase 3 C diff Trial

Expansion of antimicrobial stewardship strategies to include vertical methods represents an opportunity for programs, both new and established, to further optimize antimicrobial use.

Vertical Antimicrobial Stewardship Can Take Programs to New Heights

A dosage of 250 mg twice daily for 10 days was confirmed for the next phase of trials after achieving initial and sustained cure in 100% of patients.

C. DIFFICILE