Cytomegalovirus Vaccine Candidate Found to Be Safe & Immunogenic in First-in-Humans Trial
An eVLP cytomegalovirus (CMV) vaccine was found to be safe and immunogenic at very low doses in healthy seronegative adults.
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Comparison of Ceftolozane/Tazobactam vs Polymyxin/Amingoglycoside for Treatment of MDR/XDR Pseudomonas aeruginosa
Jason Pogue, PharmD, BCPS-AQID, discusses the need for real-world data to support Ceftolozane/tazobactam and shares the findings of his comparative study on using the regimen to treat MDR/XDR Pseudomonas aeruginosa.
Infectious Diseases and Transplantation—A Look Ahead
Taking a closer look at the infectious disease risks posed by transplantation and what the future might have in store as the scope of transplantation expands.
RESTORE-IMI 1 Trial Compares IMI/REL and IMI+CST in Patients with Bacterial Infections
Keith Kaye, MD, presented the analysis of the RESTORE-IMI 1 phase 3 trial which evaluated imipenem/cilastatin/relebactam versus imipenem/cilastatin plus colistin.
Zoonotic Transmission of the Hepatitis E Virus
Kenneth E. Sherman, MD discusses the zoonotic hepatitis E virus and about the first reported case of rat-to-human transmission.
Entering a New Era of Blood Culture Testing Technology
Melvin Weinstein, MD, discusses the current and emerging technologies for the laboratory diagnosis of bloodstream infections.
Phase 2 Trial Evaluates DAS181 for Parainfluenza Virus in Immunocompromised Patients
Roy Chemaly, MD, MPH discusses the findings of the phase 2 trial evaluating DAS181 for the treatment of parainfluenza virus lower respiratory tract infections in immunocompromised patients.
Treatment of Antibiotic-Resistant Infections: Back to the Future of Therapies
The stage may finally be set for the phage therapy era for recalcitrant bacterial infections.
The Benefits of Dual Therapy for Gram-Negative Infections: An Assessment of the Guidelines
Julie Ann Justo, PharmD, MS, BCPS-AQ ID, shares takeaways from her presentation on combination therapy for gram-negative agents at the 2018 SIDP Annual Meeting.
OPAT-Antimicrobial Stewardship Team Coordination Ideal For Improving Patient Outcomes Upon Readmission
Efforts such as improved indication documentation and antimicrobial stewardship involvement may improve patient outcomes in some patients who are on outpatient parenteral antimicrobial therapy (OPAT) for ease of administration (EOA) that are readmitted to the hospital.
Antimicrobial Stewardship Processes Streamlined with Software
New software to facilitate prior authorization helped streamline the approval process and increase antimicrobial use tracking at the Hospital of the University of Pennsylvania.
Treatment Options for Immunocompromised Patients with Hepatitis B
Kenneth Sherman, MD, discusses current trends in the treatment of hepatitis B in immunocompromised patients and highlights research exploring treatment options for patients coinfected with HIV.
Letermovir Found to Reduce Clinically Significant CMV infection in HCT Patients
Letermovir found to prevent clinically significant CMV infection in HCT patients with CMV DNA when compared to placebo in recent phase 3 trial.
Ceftolozane/Tazobactam: Real-World Treatment Patterns & Associated Outcomes
A retrospective study evaluates ceftolozane/tazobactam in a large database of US hospitals to determine real-world patterns and outcomes associated with the treatment.
Adding Fosfomycin to Daptomycin Could Improve Outcomes of MRSA Bacteremia
The combination of daptomycin plus fosfomycin was more effective than daptomycin alone for treating patients with MRSA bacteremia.
Study Provides Real-World Support for Single-Dose Oritavancin For ABSSSIs
Results indicate patients who received single-dose oritavancin were significantly less likely to be hospitalized, compared to those who received multidose vancomycin.
Top Infectious Disease News of the Week—October 1, 2018
Stay up-to-date on the latest infectious disease news by checking out our top 5 articles of the week.
Increasing Duration of Surgical Prophylaxis Does Not Decrease Odds of SSI
Instead, increasing duration of postoperative antimicrobial prophylaxis is associated with higher odds of acute kidney injury and C diff infection in a dose-dependent manner.
Off-label Use of Recently-Approved Antimicrobial Agents Is Common
Study results indicate that clinicians start prescribing new drugs off-label almost as soon as the drugs become available.
Incidence of Candidemia is Decreasing, But Not for Some Drug-Resistant Species
First large-scale study on trends in invasive candidiasis finds species distribution of isolates varied between blood and nonblood sterile sites.
Cardiac or Vascular Disease Not a Barrier to Delafloxacin For Treatment of Skin and Skin Structure Infections
Delafloxacin was found to be relatively safe and well tolerated in patients with acute bacterial skin and skin structure infections with past or present cardiac or vascular difficulties.
Analysis Underscores Substantial Burden of Candidemia in the United States
A new analysis details the substantial burden of candidemia in the United States and calls for ongoing surveillance efforts to help assess the impact of prevention interventions.
Severe Influenza May Be a Risk Factor for Aspergillosis
Over one-third of patients with invasive aspergillosis lacked a documented immunosuppressive condition.
Dr. George Thompson On Phase 2 STRIVE Study Evaluating Optimal Dosing for Rezafungin
George Thompson, MD, principal investigator of the STRIVE study discusses optimal dosing for rezafungin in treating candidemia and/or invasive candidiasis.
A Window Into the Outpatient UTI Antibiogram of New York
Researcher give insight into the importance of antibiograms in outpatient management of urinary tract infections
Patients with Carbapenem-Resistant Bloodstream Infections Less Likely to Survive Hospitalization
New research finds patients with carbapenem-resistant bloodstream infections have a lower likelihood of surviving hospitalization or being discharged home.
Progress in Fighting Ebola, Yet Resistance to Treatment in the DRC Remains
Mary Choi, MD, MPH, discusses the progress made in treating and preventing Ebola and the challenges of fighting the community resistance of the Congolese.
HIV-Positive Patients at Higher Risk of Late Mortality Following Cryptococcal Infection
Nonadherence to antiretroviral therapy was associated with a higher risk of death.
Infection Preventionists and Antimicrobial Stewardship Programs, A Marriage in Progress
A look into the challenges of including infection preventionists in antimicrobial stewardship programs.
Is “Non-Traditional” Risk Stacking the Solution for Pneumococcal Disease? Special ID Week 2018 Public Health Watch
The results of a new study suggest the approach can help stratify patients with the disease.