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Fecal Transplant Benefits C diff Patients Coinfected With COVID-19Treating Clostridioides difficile infection is complicated in patients coinfected with COVID-19. However, a new study suggests a significant benefit of fecal microbiota transplant (FMT) in these coinfected patients.
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Four Fungal Horsemen: Emerging Trends in Fungal Disease EpidemiologyNew public health perspectives on aspergillosis, sporotrichosis, histoplasmosis, and coccidioidomycosis.
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Antiretroviral Safety in Pregnancy: Focus on Dolutegravir, Integrase Inhibitors, and Neural Tube DefectsThere has been increasing interest in the association between neural tube defects, dolutegravir, and integrase inhibitors as a class since 4 cases were reported in 2018.
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Pediatric Hexavalent Combination Vaccine Approved by FDAThe vaccine is approved as a 3-dose series, which consists of a 0.5 mL intramuscular injection, administered at 2, 4, and 6 months of age.
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Alternative Antiretroviral Medication Delivery Systems Emerge to Treat, Prevent HIV InfectionNovel modes of delivery are imperative to improve HIV suppression and prevent transmission.
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FDA Grants QIDP & Fast Track Designations for SCY-078 to Treat Vulvovaginal CandidiasisThe FDA has granted QIDP and Fast Track Designations for the oral formulation of SCY-078 for the treatment of vulvovaginal candidiasis.
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Strategic Alliance Formed to Advance RNAi Therapeutics for Infectious DiseasesAlnylam Pharmaceuticals announces exclusive licensing agreement with Vir Biotechnology for the development and commercialization of RNA Interference therapeutics for infectious diseases.
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New Rules Expand Application of the NTAP Program for Innovative AntibioticsTo better support the use of critical antibiotics, the Centers for Medicare & Medicaid Services revised the rules governing reimbursement for qualifying antibiotic products. For these changes to succeed, hospital systems will need to make adjustments.
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FDA Guidance Synchronizes Launch of Antimicrobial and AST DeviceThe FDA has finalized its guidance on how to synchronize development of antimicrobials and antimicrobial susceptibility test devices.
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Final Diagnosis: Disseminated Kaposi Sarcoma With Tonsillar and Pulmonary InvolvementA shocking find on a CT scan leads to an unexpected diagnosis.
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Vaccination in 2019: Daunting Challenges and OptimismThe Closing Plenary of IDWeek 2019 discussed the challenges of vaccination and the optimism that we may be on the path to eradicating some global infectious diseases.
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Don't Rush Science: Maintaining Ethics in Exploring Countermeasures for COVID-19Michael K. Gusmano, PhD, discusses the importance of maintaining ethical standards in research evaluating potential therapeutics and vaccines for COVID-19.
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Can Fidaxomicin Provide Effective C difficile-Associated Diarrhea Prophylaxis for HSCT Recipients?Clostridium difficile rates in stem cell transplant patients are approximately 9 times greater than in hospitalized patients, with rates about twice as high in allogeneic vs autologous transplants.
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ACIP Endorses Shingrix As Preferred Shingles Vaccine for Adults Aged 50 & OlderThe CDC’s ACIP recommends newly FDA-approved Shingrix as the preferred vaccine for the prevention of shingles in individuals 50 years of age or older.
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New and Pipeline Antiretroviral Agents for the Treatment of HIV-1 InfectionThis article seeks to review newer ART agents, as well as those in later stages of drug development, for the treatment of HIV-1 infection.
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Get Off the SOFA! Introducing the Quick Pitt Bacteremia ScoreThe quick Pitt Bacteremia Score offers accuracy comparable to the original version's across multiple infections, and maintains ease of use.
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The Great Debate: Polymyxin B Versus Polymyxin EAs we await novel compounds from a relatively apathetic industry, we are resurrecting antibiotics of which we have an outdated understanding. and that carry the potential for substantial side effects: polymyxins.
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Biktarvy: A Regimen of Choice for HIV TherapyThe new single-tablet regimen provides a safe and effective treatment option for patients with HIV.
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Multidrug-Resistant Pseudomonas aeruginosa Infections: Hard to Treat, But Hope on the Horizon?Two recently approved agents offer significant activity against these hard-to-treat conditions.
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COVID-19 Treatment: Updates March 19-24, 2020Erin K. McCreary, PharmD, BCPS, BCIDP; and Jason M. Pogue, PharmD, BCPS, BCIDP, provide an update of published literature on experimental treatments for COVID-19 from the past week.
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Implications of the 21st Century Cures Act on Antibiotic Drug DevelopmentExperts weigh in on what Congress is doing to tackle the threat of antibiotic resistance.
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Appropriate or Not? A Look at Antibiotic Use in the Emergency DepartmentThis In the Literature piece details a study evaluating the appropriateness of prescriptions in comparison to evidence-based guidelines and expert opinion.
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Strep Throat—To Fear or Not to Fear (Again)?Reports of serious consequences from severe streptococcal infections have caused fear among the general public, but is this fear warranted?
