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The ART of Implementing an Antiretroviral Stewardship ProgramBy addressing ART-related medication errors and increasing linkage to care, antiretroviral stewardship programs can improve management of inpatients with HIV.
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Molecular Diagnostics for Bacterial Pneumonia Need Testing StewardshipOngoing education and proven outcomes need to aid this form of testing.
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An Update on LenacapavirThis new antiretroviral with a unique mechanism of action may be lifesaving for those with treatment-resistant HIV infection.
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Why Aren’t We Better Protecting Our Youngest Children Against Infections?Vaccinations and mitigations for COVID-19 and other respiratory viruses have not been made a priority for young children. Let’s change this before the next big surge hits.
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To Prophylax or not to Prophylax: Preventing CDIClinicians look at optimal approaches for trying to avoid Clostridioides difficile infection (CDI).
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So You Made the Decision to Implement Vancomycin AUC Dosing. Now What?Since the vancomycin guideline update, institutional leaders have been faced with the challenge of implementing and monitoring AUC-guided dosing.
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Going Viral on Social Media: Integrating Digital Tools into Pharmacy RotationsIn the latest Bench to Bedside column, 2 clinicians discuss the benefits of utilizing social media for learning.
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Bad Bugs, New Drugs: A Discussion of Selected New Therapeutics From IDWeek 2022Cefepimetaniborbactam may represent a safe and effective carbapenemsparing agent in cUTI and AP, whereas ridinilazole may play an important role in treating CDI.
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Tricky Infusion Issues and Potential Solutions: OPAT EditionOutpatient parenteral antimicrobial therapy (OPAT) offers benefits for patients as well as providing cost effectiveness; however, it is not without its challenges. Two clinicians provide insights on this modality.
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Treating Zaire ebolavirus With Ansuvimab-zyklThe recombinant human IgG1κ monoclonal antibody binds and neutralizes the virus.
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Reduced-Dose Trimethoprim-Sulfamethoxazole Effective in Treating Mild to Moderate Pneumocystis jirovecii PneumoniaHere is a review of using this therapy in this patient population.
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New Recommendations for Antibiotic Prophylaxis Prior to Dental ProceduresThe American Dental Association (ADA) has updated patient profiles on who should be indicated for antibiotic prophylaxis.
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Precision Dosing of To-Marrow: Linezolid Therapeutic Drug MonitoringEmerging literature suggests therapeutic drug monitoring for this antimicrobial to minimize the risk for linezolid-associated toxicities while maintaining efficacy in select populations.
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Will We Ever See Oral Carbapenems for ESBL Urinary Tract Infections?Recent issues surrounding the ADAPT-PO and SURE-2 trials place the spotlight on the difficulties developing oral carbapenem-based antibiotics and case their future into doubt.
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From Single-Use to Multi-Use: A Brief Review of N95 Respirator Decontamination StrategiesThis indispensable personal protective equipment did come up in short supply and reuse strategies has become a topic of great interest and research.
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Unveiling Gender Disparities in Lyme Disease: A Critical Analysis of Persistent IllnessVery few Lyme disease studies consider sex- and gender-based differences. Is this flawing the research?
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PrEP State of the Union: Adherence, Access, Uptake IssuesAlthough this form of prophylaxis is highly protective, there are situations in which breakthrough infections occur.
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CDC Presents Core Elements for Sepsis ProgramsThis new program from the federal agency can be viewed as a useful starting point for the development and assessment tool for sepsis programs with more granularity required.
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Employee Health After the COVID-19 Pandemic: Stronger Than YesterdayFor providers on the front lines, lessons learned can help inform strategies to enhance the protection of their health going forward.
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Where Do We Draw the Line? Duration of Antibiotic Therapy Varies for Bloodstream InfectionsWith potential delays in treatment, bloodstream infections can be concerning for clinicians. Here is a review of the literature that offer guidance for treatment.
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Strengths and Limitations of T2Candida Implementation From an Antimicrobial Stewardship PerspectiveThis novel, rapid diagnostic assay uses polymerase chain reaction and magnetic resonance to identify the 5 most common Candida species.
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Clinical Considerations in Conducting Antifungal Susceptibility TestingAccess to antifungal susceptibility testing (AFST) remains limited in the United States. Therefore, providers must recognize clinical situations where AFST will provide its greatest value. In the latest article from SIDP, infectious disease pharmacists offers some insights on this subject.
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Weekly Flu Report Finds Sporadic InfectionsThis flu season, the CDC reported at least 2.4 million flu illnesses, 23,000 hospitalizations, and 1,400 deaths from flu so far.
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Recent Research Indicates That We're Falling Short on HBV Elimination TargetsOrganizations look at an agent-based model to assess the impact of vaccination, screening, and treatment on incidence and prevalence of HBV in Ontario, Canada.
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The Variety of Variants in COVID-19The evolution of the major variants, including the delta mutation.
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Practice Pearls for Treatment of Respiratory InfectionsTina Tan, MD; Wendy Wright, DNP, ANP-BC, FNP-BC, FAANP, FAAN, FNAP; Priya Nori, MD; Jacinda Abdul-Mutakabbir, PharmD; and Kevin Michael Reiter, MD, PA, provide key takeaways from the discussion on the treatment of respiratory viral infections.
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HIV CRISPR Therapy Fast-Tracked by the FDAThe phase 1/2 trial evaluating EBT-101 dosed its first patient in September 2022.
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Expanded Treatment Options for Multi-Drug Resistant Infections in ChildrenIn the latest article from SIDP, here is a look at therapy options addressing this emerging clinical challenge.
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UTIs: Why Did You Have to Go and Make Things so Complicated?Although hospitalizations due to urinary tract infections have increased, there are some investigational antibiotics in clinical trials. Here is a review of some of these therapies in the pipeline.
