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Bioaccumulation of Drugs by Human Gut Bacteria Can Affect Drug AvailabilityA new study demonstrated that gut organisms can alter drug availability by biotransformation on a significantly broader scale than previously expected.
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Pfizer's C. difficile Vaccine Succeeds in Phase II StudyResearchers found the experimental vaccine could potentially inhibit severe diarrhea and pseudomembranous colitis by inducing a functional antibody response that can neutralize the two main disease-causing toxins (toxin A or B) produced by C. difficile.
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Researchers Are Working on a Promising Novel Herpes VaccineAlbert Einstein College of Medicine researchers have developed a new vaccine type that shows promise to possibly become the first ever for preventing genital herpes.
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HIV Treatment Advice for Community PhysiciansExperts provide community physicians treating HIV with practical advice for screening, diagnosing, and managing patients with HIV.
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Have we made progress in the 10 X' 20 Initative?IDSA reached its goal, but nobody’s buying. Can the drowning antimicrobial pipeline be saved?
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Hepatitis C Virus: Task Shifting and ScreeningClinicians discuss screening and treatment approaches for the disease.
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Addressing Shortcomings in Infection and Sepsis Treatment Should Be Top of the Priority ListAs clinicians and health care executives work to strike a balance between reducing costs and improving clinical outcomes, the importance of sepsis identification and treatment cannot be underscored enough, and starts with evaluating current practices for infection management.
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The Public Health Threat of Ice Cream TamperingVideos of individuals licking ice cream and placing these cartons back on freezer store shelves have gone viral, and this practice can pose public health risks.
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Using IL-6 Inhibitors to Treat COVID-19Use of an IL-6 inhibitor has the potential to prevent the cytokine storm caused by severe COVID-19 infection.
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Genomic Features of the 2015 Elizabethkingia OutbreakResearchers from Pasteur Institute, Paris, France, and the Centers of Disease Control and Prevention, examine the genomic features of the E. anophelis strain behind the 2015-2016 Wisconsin outbreak.
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New Line of HIV Treatment Identified for Patients Ineligible for EfavirenzA national clinical trial has found non-efavirenz antiretroviral therapy effective as a first-line treatment, which is good news for patients with HIV who are ineligible to usea the common drug.
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COVID-19 Complicates an Already Difficult Presentation of Infective EndocarditisFinal Diagnosis: Infective Endocarditis Due to Granulicatella adiacens and Streptococcus mitis.
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A Case of CNS Nocardia farcinica Presenting as Aphasia in an Immunocompetent HostQuick recognition is key to early initiation of treatment and long-term survival.
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Clinical Outcomes of Vancomycin Mono or Combination Therapy with a Beta-Lactam Against MRSA BacteremiaMethicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with high mortality.
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The Case of Late Aspergillus Fumigatus Infection of Implantable Cardioverter Defibrillator LeadsQuick action was needed against this very rare cause of fungal endocarditis.
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Daptomycin Dosing in Obesity: Consideration for a Fixed-Dose StrategyThis In the Literature piece considers a fixed-dose strategy for administering daptomycin in obese patients.
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Treating Outpatient Cystitis in the Era of Antimicrobial ResistanceWhat can clinicians do now that increasing resistance has limited oral treatment options for outpatient cystitis?
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Acute Bacterial Skin and Skin Structure Infections: A Modernized ApproachThe emergence of hospital- and community-based MRSA and other resistant gram-positive pathogens have made ABSSSI a critical public health challenge.
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What's New In 2024: From the CLSI Subcommittee on Antimicrobial Susceptibility TestingThe Clinical and Laboratory Standards Institute (CLSI) Subcommittee on Antimicrobial Susceptibility Testing had its series of meetings to update breakpoints for a variety of classes of antimicrobials.
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Phase 3 Trial of Bulevirtide Yields Positive ResultsFor people living with chronic hepatitis D, the latest study results confirm the benefit of injections of this first-in-class entry inhibitor.
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Contagion® Interviews Pat Smith to Mark Lyme Disease Awareness MonthIn recognition of Lyme disease awareness month, Contagion® interviewed Pat Smith, president of Lyme Disease Association, Inc, to better understand current issues surrounding the diagnosis and treatment of Lyme disease.
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C Difficile Infection Is Associated With Higher Mortality Rates in Patients With CirrhosisClostridium difficile infection leads to higher rates of overall mortality among patients with cirrhosis compared to those who do not, according to a new study.
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Antiretroviral Safety in Pregnancy: Focus on Dolutegravir, Integrase Inhibitors, and Neural Tube DefectsThere has been increasing interest in the association between neural tube defects, dolutegravir, and integrase inhibitors as a class since 4 cases were reported in 2018.
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The Continued Search for Optimal Daptomycin Dosing Strategies in VRE Bloodstream InfectionsOptimal dosing of daptomycin is unknown, but study results suggest higher doses are required for successful clinical and microbiological outcomes.
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Implications of the 21st Century Cures Act on Antibiotic Drug DevelopmentExperts weigh in on what Congress is doing to tackle the threat of antibiotic resistance.
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How Does HIV Affect the Brain?Dr. Shibani Mukerji discusses how HIV affects the brain as part of a symposium at ID Week 2017.
