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Diagnosis and Treatment of Chronic Lyme Disease: A Complex IssueRecognition of chronic Lyme disease and the role of long-term antibiotic treatment for persistent symptoms continue to be controversial among researchers, providers, patients, and advocates.
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Effectiveness of Pertussis Vaccine May Wane Over Time, Study ShowsKaiser Permanente Northern California’s study shows that the pertussis vaccine weakens as time passes after a patient's most recent vaccination.
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Pfizer Foundation Donates Millions to Help Combat ZikaThe CDC Foundation and the Florida Department of Health have announced that the the Pfizer Foundation has donated millions to improve Zika response efforts.
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Outpatient Antimicrobial Stewardship: Field of Dreams or Land of Opportunity for Pharmacists?Relevant existing reports, though limited, demonstrated positive outcomes and suggest a promising space for pharmacy practice growth in outpatient antimicrobial stewardship.
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Diagnostic Stewardship: Beyond Managing Bloodstream InfectionsDiagnostic stewardship is a novel concept related to modifying the process of ordering, testing, and reporting with the goal of decreasing unnecessary testing and treatment, working upstream and synergistically with antimicrobial stewardship principles.
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COVID-19, SARS-CoV-2 and Pregnancy: Does the Past Predict the Present?Preliminary evidence indicates no direct evidence for intrauterine transmission of the SARS-CoV-2 virus from pregnant women with COVID-19 to their infants.
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Bacteriophage-Antibiotic Combinations: A Promising Alternative for Refractory Infections?Despite the initial abandonment of bacteriophages in most areas of the world, the era of antibiotic resistance has led to a resurgence of phage therapy in clinical practice.
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Intravenous Fosfomycin for Systemic Multidrug-Resistant InfectionsIntravenous (IV) fosfomycin offers a novel therapeutic option in the treatment of systemic multi-drug resistant (MDR) infections. Unanswered questions remain regarding its efficacy and specific role in our therapeutic arsenal.
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Shoutout to the Stewards: Holiday EditionContagion® radio is here to bring joy with every new antibiotic alert!
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Get Off the SOFA! Introducing the Quick Pitt Bacteremia ScoreThe quick Pitt Bacteremia Score offers accuracy comparable to the original version's across multiple infections, and maintains ease of use.
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What's New From the CLSI Subcommittee on Antimicrobial Susceptibility TestingUpdates include novel and revised breakpoints for azithromycin, polymyxins, daptomycin, and cefiderocol.
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Pan-resistant, Currently Untreatable Gram-Negative Infections Come Closer to HomeThe global emergence of antimicrobial resistance among gram-negative species is a major public health concern.
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Investigational Treatments for Clostridioides difficile InfectionThe high recurrence rates of Clostridioides difficile infection highlight the need for novel agents with unique mechanisms of action for treating the infection.
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Pandemic Disrupts Progress Toward Hepatitis B ControlEfforts to ramp up hepatitis B vaccination at birth and in infancy are crucial to controlling the disease in Africa, which accounted for 66% of new infections in 2019.
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A Long-Term Care Antimicrobial Stewardship Certificate Program for Pharmacists: Filling an Unmet NeedThis training will empower pharmacists practicing in LTC facilities to develop antimicrobial stewardship programs, improve patient outcomes related to infectious diseases, and facilitate compliance with CMS requirements.
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Controversies of Antimicrobial Transitions in Adults With Gram-Negative BacteremiaMoving away from the standard course of IV antibiotics.
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HCV Testing Remains Low Among High-Risk PopulationWhen the US Preventive Services Task Force (USPSTF) recommended that all baby boomers undergo a one-time hepatitis C screening in 2013, testing prevalence increased. However, the rate is still lower than officials would like to see.
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Is Investment in New Technologies for Diagnosing Schistosomiasis Justified in an Era of Schistosoma Elimination?The emergence of new species creates pressure for developing affordable and reliable diagnostic strategies.
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CabA May Hold Key to Reducing Food-borne Illnesses Caused by Vibrio vulnificusBy targeting CabA, an extracellular matrix protein essential for biofilm formation, it may be possible to reduce the incidence of food-borne illnesses caused by the potentially lethal Vibrio vulnificus marine bacterium found in biofilms on oyster shells and meat.
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Implants for Delivery of Antiretroviral Drugs for HIV Pre-Exposure ProphylaxisImplants are promising for long-term, sustained, and reversible delivery of ARV drugs that may bypass adherence challenges for end users.
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Reassessing Practices Is Critical During an Infectious Disease OutbreakThe constant reassessment of business practices is necessary to ensure that practitioners are not wasting valuable time, resources, and effort on activities that are not producing the desired results.
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Role of Immunosuppression on Community-Acquired Clostridioides difficile RiskCDI remains an urgent public health threat and continues to be the most frequent cause of diarrhea among hospitalized patients and overall hospital-acquired infection in the United States.
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The Early Bird Gets to Stay Home: Early OPAT Follow-Up Reduces 30-Day ReadmissionsReadmission rates for patients receiving OPAT are reported to be as high as 20%, mostly due to catheter-related problems, adverse drug reactions, or worsening of the primary infection.
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Get Off the SOFA! Introducing the Quick Pitt Bacteremia ScoreThe quick Pitt Bacteremia Score offers accuracy comparable to the original version's across multiple infections, and maintains ease of use.
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The Case of Late Aspergillus Fumigatus Infection of Implantable Cardioverter Defibrillator LeadsQuick action was needed against this very rare cause of fungal endocarditis.
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The Power of PrEPThe results of a new study demonstrate that PrEP can reduce new infections within a population even when the risk of HIV remains high and other proven treatment and prevention strategies are optimized.
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Conversations Around Discharge and Potential Outpatient Treatment Follow-upJones offered his insights for discharging patients as well as follow-up outpatient treatment.
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Fluoroquinolone Antibiotics: More Recommendations for Prudent UseDespite concerning findings and warnings, fluoroquinolones have remained one of the world’s most commonly prescribed antibiotic classes, with the United States accounting for more than 32 million prescriptions in 2015 alone.
